Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Steven C. Pohnert"'
Autor:
John G. Shelton, Richard A. Franklin, James A. McCubrey, Steven C. Pohnert, Linda S. Steelman, Fred E. Bertrand
Publikováno v:
Leukemia. 18:189-218
The roles of the JAK/STAT, Raf/MEK/ERK and PI3K/Akt signal transduction pathways and the BCR-ABL oncoprotein in leukemogenesis and their importance in the regulation of cell cycle progression and apoptosis are discussed in this review. These pathways
Autor:
Steven C. Pohnert, John B. Knight, Paul S. MacLean, Ann Louise Olson, Donghai Zheng, G. Lynis Dohm, William W. Winder
Publikováno v:
Journal of Applied Physiology. 91:1073-1083
Skeletal muscle GLUT-4 transcription in response to treatment with 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR), a known activator of AMP-activated protein kinase (AMPK), was studied in rats and mice. The increase in GLUT-4 mRNA level
Autor:
James D. Fluckey, G. Lynis Dohm, Todd A. Trappe, Steven C. Pohnert, S. Greg Boyd, Ronald N. Cortright
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 279:E182-E187
The obese Zucker rat is resistant to insulin for glucose disposal, but it is unknown whether this insulin resistance is accompanied by alterations of insulin-mediated muscle protein synthesis. We examined rates of muscle protein synthesis either with
Autor:
Paul B. Rosenberg, Mei Zhang, Steven C. Pohnert, Zhen Yan, Takayuki Akimoto, Ping Li, R. Sanders Williams, Curtis Gumbs
Publikováno v:
The Journal of biological chemistry. 280(20)
Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) promotes mitochondrial biogenesis and slow fiber formation in skeletal muscle. We hypothesized that activation of the p38 mitogen-activated protein kinase (MAPK) pathwa
Autor:
William L. Blalock, John G. Shelton, John T. Lee, Martyn K. White, P W Moye, Richard A. Franklin, Steven C. Pohnert, Linda S. Steelman, Fumin Chang, M. Pearce, James A. McCubrey
Publikováno v:
Advances in enzyme regulation. 41
Autor:
John T. Lee, C. Burrows, William L. Blalock, Linda S. Steelman, James A. McCubrey, Richard A. Franklin, Fumin Chang, Martin McMahon, M. Pearce, Steven C. Pohnert
Publikováno v:
Leukemia. 15(5)
The Raf/MEK/MAP kinase cascade plays a critical role in transducing growth signals from activated cell surface receptors. Using deltaMEK1:ER, a conditionally active form of MEK1, we demonstrate the ability of this dual specificity protein kinase to a