Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Steven C. Greenway"'
Treatment of RAF1-Related Obstructive Hypertrophic Cardiomyopathy by MEK Inhibition Using Trametinib
Autor:
Omid Kiamanesh, MD, Steven C. Greenway, MD, Franciscus Dicke, MD, MBA, Brennan Ballantyne, MD, Sasha Mitrovic, RDCS, Kaitlin McGrath, MD, James A. White, MD, William D.T. Kent, MD, Gregor Andelfinger, MD
Publikováno v:
JACC: Case Reports, Vol 29, Iss 13, Pp 102379- (2024)
RASopathies cause nonsarcomeric hypertrophic cardiomyopathy via dysregulated signaling through RAS and upregulated mitogen-activated protein kinase activity. We provide the first report of the successful treatment of an adult with RAF1-associated hyp
Externí odkaz:
https://doaj.org/article/9cbf8ae779bf410c9b90d4e76e614784
Publikováno v:
Toxins, Vol 16, Iss 8, p 345 (2024)
Chronic kidney disease (CKD) can lead to cardiac dysfunction in a condition known as cardiorenal syndrome (CRS). It is postulated that the accumulation of uremic toxins in the bloodstream, as a consequence of declining kidney function, may contribute
Externí odkaz:
https://doaj.org/article/a87a8fd428a2424497c7c121aaf1411b
Autor:
R. Brian Lowry, Tanya Bedard, Xin Grevers, Susan Crawford, Steven C. Greenway, Mary E. Brindle, Harvey B. Sarnat, A. Robertson Harrop, Gerhard N. Kiefer, Mary Thomas
Publikováno v:
Health Promotion and Chronic Disease Prevention in Canada, Vol 43, Iss 1, Pp 40-48 (2023)
IntroductionCurrent published long-term provincial or territorial congenital anomaly data are lacking for Canada. We report on prevalence (per 1000 total births) and trends in 1997–2019, in Alberta, Canada, for selected congenital anomalies. Associ
Externí odkaz:
https://doaj.org/article/007dedce446948fbad9935d2e0966e99
Autor:
R. Brian Lowry, Tanya Bedard, Xin Grevers, Susan Crawford, Steven C. Greenway, Mary E. Brindle, Harvey B. Sarnat, A. Robertson Harrop, Gerhard N. Kiefer, Mary Thomas
Publikováno v:
Promotion de la santé et prévention des maladies chroniques au Canada, Vol 43, Iss 1, Pp 42-51 (2023)
IntroductionOn manque de données provinciales ou territoriales à long terme publiées et actuelles sur les anomalies congénitales Au Canada. Cette étude fait état de la prévalence (pour 1000 naissances totales) et des tendances pour diverses an
Externí odkaz:
https://doaj.org/article/c2ac3f66a9eb4081b279e822012d89ce
Autor:
Kevin G. Friedman, MD, Brian W. McCrindle, MD, MPH, Kyle Runeckles, MSc, Nagib Dahdah, MD, Ashraf S. Harahsheh, MD, Michael Khoury, MD, Sean Lang, MD, Cedric Manlhiot, PhD, Adriana H. Tremoulet, MD, MAS, Geetha Raghuveer, MD, Elif Seda Selamet Tierney, MD, Pei-Ni Jone, MD, Jennifer S. Li, MD, MHS, Jacqueline R. Szmuszkovicz, MD, Kambiz Norozi, MD, PhD, Supriya S. Jain, MD, Angela T. Yetman, MD, Jane W. Newburger, MD, MPH, Carolyn A. Altman, MD, Brett R. Anderson, MD, MBA, MS, Mikayla Beckley, BS, Elizabeth Braunlin, MD, PhD, Jane C. Burns, MD, Michael R. Carr, MD, Nadine F. Choueiter, MD, Jessica H. Colyer, MD, MBA, Frederic Dallaire, MD, PhD, Sarah D. De Ferranti, MD, MPH, Laurent Desjardins, MD, Matthew D. Elias, MD, Anne Ferris, MBBS, Michael Gewitz, MD, Therese M. Giglia, MD, Steven C. Greenway, MD, Kevin C. Harris, MD, MHSc, Kevin D. Hill, MD, MSc, Michelle Hite, Thomas R. Kimball, MD, Shelby Kutty, MD, Lillian Lai, MD, MHA, Simon Lee, MD, Ming-Tai Lin, MD, PhD, Tisiana Low, MD, MSc, Andrew S. Mackie, MD, MSc, Wadi Mawad, MD, Mathew, MSc, Kimberly E. McHugh, MD, Tapas Mondal, MD, Kimberly Myers, MD, Michael A. Portman, MD, Claudia Renaud, MD, Rosie Scuccimarri, MD, S. Kristen Sexson Tejitel, MD, PhD, MPH, Karen M. Texter, MD, Deepika Thacker, MD, Sharon Wagner-Lees, RN-BC, BSN, Kenny Wong, MD, Mei-Hwan Wu, MD, PhD, Varsha Zadokar, MBBS
Publikováno v:
CJC Pediatric and Congenital Heart Disease, Vol 1, Iss 4, Pp 174-183 (2022)
Background: The impact of adjunctive anti-inflammatory treatment on outcomes for patients with Kawasaki disease (KD) and coronary artery aneurysms (CAAs) is unknown. Methods: Using data from the International KD Registry in patients with ≥ medium C
Externí odkaz:
https://doaj.org/article/1a1d47ee96ea419f8fe01dc25ed1396f
Autor:
Nazanin Vaziri, Diogo Marques, Xuemei Wang, Pranav Machiraju, Ankita Narang, Katerina Vlahos, Christos Pantelis, Steven C. Greenway, Chad A. Bousman
Publikováno v:
Stem Cell Research, Vol 63, Iss , Pp 102877- (2022)
Clozapine has superior efficacy in the treatment of refractory schizophrenia; however, use of clozapine is limited due to severe side effects, including myocarditis. Using non-integrative Sendai virus, we generated induced pluripotent stem cell lines
Externí odkaz:
https://doaj.org/article/f108f4af4b2549aab43d7117d2e47768
Autor:
Frédéric Dallaire, MD, PhD, Marie-Claude Battista, PhD, Steven C. Greenway, MSc, MD, Kevin Harris, MD, PhD, Emilie Jean-St-Michel, MD, MSc, Andrew S. Mackie, MD, SM
Publikováno v:
CJC Open, Vol 3, Iss 4, Pp 510-515 (2021)
Background: Common hurdles to pediatric cardiology research include the heterogeneity and relative rarity of specific cardiac malformations, the potential for effect of residual lesions occurring decades after repair, and the scarcity of objective an
Externí odkaz:
https://doaj.org/article/609c75ac2c5c496b817f1eb05293e68e
Autor:
Steven C. Greenway, MSc, MD, FRCPC, Deborah Fruitman, MD, FRCPC, Raechel Ferrier, MSc, MA, CCGC, Cathleen Huculak, MSc, CCGC, Julien Marcadier, MD, FRCPC, Consolato Sergi, MD, PhD, FRCPC, Francois P. Bernier, MD, FRCPC
Publikováno v:
CJC Open, Vol 3, Iss 10, Pp 1300-1302 (2021)
We report a family with 2 neonatal deaths related to dilated cardiomyopathy (DCM) and compound heterozygous loss-of-function variants (c.1243_1244del, p.Leu415Valfs*108 and c.1537C > T, p.Arg513*) in Leiomodin 2 (LMOD2), a recently documented cause o
Externí odkaz:
https://doaj.org/article/60b3eec0c6164d55b62c618570873234
Publikováno v:
Applied Sciences, Vol 12, Iss 21, p 10946 (2022)
Approximately 10% of congenital heart diseases (CHDs) include Tetralogy of Fallot (TOF). Fortunately, due to advanced surgical techniques, most patients survive until adulthood. However, these patients require frequent monitoring for postoperative co
Externí odkaz:
https://doaj.org/article/5fa8e1b6c7764e489cddf4423d1e276c
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3353 (2022)
Human mitochondrial disorders impact tissues with high energetic demands and can be associated with cardiac muscle disease (cardiomyopathy) and early mortality. However, the mechanistic link between mitochondrial disease and the development of cardio
Externí odkaz:
https://doaj.org/article/73f7db177112456a9a5dfbfcfbd85ce2