Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Steven C. Chen"'
Autor:
Richard L. Frock, Steven C. Chen, Dao-Fu Dai, Ellie Frett, Carmen Lau, Christina Brown, Diana N. Pak, Yuexia Wang, Antoine Muchir, Howard J. Worman, Luis F. Santana, Warren C. Ladiges, Peter S. Rabinovitch, Brian K. Kennedy
Publikováno v:
PLoS ONE, Vol 7, Iss 9 (2012)
Externí odkaz:
https://doaj.org/article/29d9bcf7338142eb8ccdd8273928f023
Autor:
Richard L Frock, Steven C Chen, Dao-Fu Da, Ellie Frett, Carmen Lau, Christina Brown, Diana N Pak, Yuexia Wang, Antoine Muchir, Howard J Worman, Luis F Santana, Warren C Ladiges, Peter S Rabinovitch, Brian K Kennedy
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42918 (2012)
Lmna(-/-) mice display multiple tissue defects and die by 6-8 weeks of age reportedly from dilated cardiomyopathy with associated conduction defects. We sought to determine whether restoration of lamin A in cardiomyocytes improves cardiac function an
Externí odkaz:
https://doaj.org/article/474b2d0db8044ac2a121f210bd305299
Autor:
Steven C Chen, Ellie Frett, Joseph Marx, Darko Bosnakovski, Xylena Reed, Michael Kyba, Brian K Kennedy
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19780 (2011)
Although recent publications have linked the molecular events driving facioscapulohumeral muscular dystrophy (FSHD) to expression of the double homeobox transcription factor DUX4, overexpression of FRG1 has been proposed as one alternative causal age
Externí odkaz:
https://doaj.org/article/d5bbcfa0dd4f45648f50f3e4aab60b9e
Autor:
Steven C. Chen, Ying Wei, Ying Xi, Yong-Hyun Kim, Thomas J. Kim, Kevin Tan, Alexis N. Brumwell, Harold A. Chapman
Publikováno v:
American journal of respiratory cell and molecular biology, vol 50, iss 1
A high-throughput small-molecule screen was conducted to identify inhibitors of epithelial-mesenchymal transition (EMT) that could be used as tool compounds to test the importance of EMT signaling in vivo during fibrogenesis. Transforming growth fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe46797e9b2d3a8ce65e417b52741e9
https://pubmed.ncbi.nlm.nih.gov/23944988
https://pubmed.ncbi.nlm.nih.gov/23944988
An understanding of the molecular mechanism behind the arrhythmic phenotype associated with laminopathies has yet to emerge. A-type lamins have been shown to interact and sequester activated phospho-ERK1/2(pERK1/2) at the nucleus. The gap junction pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd14d139350d90e416414397e5ecce9
https://europepmc.org/articles/PMC3594536/
https://europepmc.org/articles/PMC3594536/
Autor:
Steven C. Chen, Randy Strong, Elroy H. An, Vivian L. MacKay, Chen-Yu Liao, Peter S. Rabinovitch, Warren C. Ladiges, Matt Kaeberlein, Dao-Fu Dai, Katherine H. Schreiber, Michael G. Garelick, Brian K. Kennedy, Fresnida J. Ramos
Publikováno v:
Science translational medicine. 4(144)
Mutations in LMNA, the gene that encodes A-type lamins, cause multiple diseases including dystrophies of the skeletal muscle and fat, dilated cardiomyopathy, and progeria-like syndromes (collectively termed laminopathies). Reduced A-type lamin functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e93e50b1825af97f659bfbb94e4ae7c1
https://pubmed.ncbi.nlm.nih.gov/22837538
https://pubmed.ncbi.nlm.nih.gov/22837538
Autor:
Christina Brown, Warren C. Ladiges, Diana N. Pak, Howard J. Worman, Dao Fu Da, Luis Fernando Santana, Yuexia Wang, Richard L. Frock, Ellie Frett, Steven C. Chen, Brian K. Kennedy, Antoine Muchir, Peter S. Rabinovitch, Carmen Lau
Publikováno v:
PloS one, vol 7, iss 8
PLoS ONE
PLoS ONE, Vol 7, Iss 8, p e42918 (2012)
PLoS ONE
PLoS ONE, Vol 7, Iss 8, p e42918 (2012)
Lmna(-/-) mice display multiple tissue defects and die by 6-8 weeks of age reportedly from dilated cardiomyopathy with associated conduction defects. We sought to determine whether restoration of lamin A in cardiomyocytes improves cardiac function an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d60a1d5403ac54da74e162f97c7430
https://escholarship.org/uc/item/8k60g47z
https://escholarship.org/uc/item/8k60g47z
Publikováno v:
Molecular Therapy. 13:S329-S330
Top of pageAbstract Recombinant activated factor VII (rFVIIa) has been used as an effective alternative treatment for hemophilia patients who have developed inhibitors. We have successfully modeled a nonviral gene therapy approach to deliver factor V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811f08b5908a32d2be7df5619d517cce
https://doi.org/10.1016/j.ymthe.2006.08.942
https://doi.org/10.1016/j.ymthe.2006.08.942
Publikováno v:
Blood. 106:5543-5543
A major problem for clinical treatment of hemophilia A using factor replacement therapy is the high frequency formation of inhibitory antibodies against factor VIII. This problem is also predicted to occur following strategies currently aimed at targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e92a24883fc06a156e52263716ebb8a
https://doi.org/10.1182/blood.v106.11.5543.5543
https://doi.org/10.1182/blood.v106.11.5543.5543
Publikováno v:
Molecular Therapy. 11:S237
A major problem for clinical treatment of hemophilia A using factor replacement therapy is the high frequency formation of inhibitory antibodies against factor VIII. This problem is also predicted to occur following strategies currently aimed at targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02315cdf36a029c64320e73966eb48bc
https://doi.org/10.1016/j.ymthe.2005.07.151
https://doi.org/10.1016/j.ymthe.2005.07.151