Zobrazeno 1 - 10
of 443
pro vyhledávání: '"Steven C. Almo"'
Autor:
Nicolas Grosjean, Estella F. Yee, Desigan Kumaran, Kriti Chopra, Macon Abernathy, Sandeep Biswas, James Byrnes, Dale F. Kreitler, Jan-Fang Cheng, Agnidipta Ghosh, Steven C. Almo, Masakazu Iwai, Krishna K. Niyogi, Himadri B. Pakrasi, Ritimukta Sarangi, Hubertus van Dam, Lin Yang, Ian K. Blaby, Crysten E. Blaby-Haas
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Heme has a critical role in the chemical framework of the cell as an essential protein cofactor and signaling molecule that controls diverse processes and molecular interactions. Using a phylogenomics-based approach and complementary structu
Externí odkaz:
https://doaj.org/article/eaa9432c18444e92ae265f34950f8b4c
Autor:
Megan M. Slough, Rong Li, Andrew S. Herbert, Gorka Lasso, Ana I. Kuehne, Stephanie R. Monticelli, Russell R. Bakken, Yanan Liu, Agnidipta Ghosh, Alicia M. Moreau, Xiankun Zeng, Félix A. Rey, Pablo Guardado-Calvo, Steven C. Almo, John M. Dye, Rohit K. Jangra, Zhongde Wang, Kartik Chandran
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Andes virus (ANDV) and Sin Nombre virus (SNV) are the etiologic agents of severe hantavirus cardiopulmonary syndrome (HCPS) in the Americas for which no FDA-approved countermeasures are available. Protocadherin-1 (PCDH1), a cadherin-superfam
Externí odkaz:
https://doaj.org/article/f3b912d0b0034e259a6b83f7a5d19e50
Autor:
Victor Danelon, Sarah C. Garret-Thomson, Steven C. Almo, Francis S. Lee, Barbara L. Hempstead
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Despite structural similarity with other tumor necrosis factor receptor superfamily (TNFRSF) members, the p75 neurotrophin receptor (p75NTR, TNFR16) mediates pleiotropic biological functions not shared with other TNFRs. The high level of p75NTR expre
Externí odkaz:
https://doaj.org/article/43064b6f66d44d61aace756a1ac08153
Autor:
Natalia Cheshenko, Jeffrey B. Bonanno, Hans-Heinrich Hoffmann, Rohit K. Jangra, Kartik Chandran, Charles M. Rice, Steven C. Almo, Betsy C. Herold
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Abstract Herpes simplex virus (HSV) receptor engagement activates phospholipid scramblase triggering Akt translocation to the outer leaflet of the plasma membrane where its subsequent phosphorylation promotes viral entry. We hypothesize that this pre
Externí odkaz:
https://doaj.org/article/866ea4e637e248b58ed8a93146f4518b
Autor:
Masayuki Kuraoka, Clare Burn Aschner, Ian W. Windsor, Aakash Mahant Mahant, Scott J. Garforth, Susan Luozheng Kong, Jacqueline M. Achkar, Steven C. Almo, Garnett Kelsoe, Betsy C. Herold
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)
There is an unmet need for monoclonal antibodies (mAbs) for prevention or as adjunctive treatment of herpes simplex virus (HSV) disease. Most vaccine and mAb efforts focus on neutralizing antibodies, but for HSV this strategy has proven ineffective.
Externí odkaz:
https://doaj.org/article/4df2398651ce41ada8275773b8c44edc
Autor:
Megan M. Slough, Rong Li, Andrew S. Herbert, Gorka Lasso, Ana I. Kuehne, Stephanie R. Monticelli, Russell R. Bakken, Yanan Liu, Agnidipta Ghosh, Alicia M. Moreau, Xiankun Zeng, Félix A. Rey, Pablo Guardado-Calvo, Steven C. Almo, John M. Dye, Rohit K. Jangra, Zhongde Wang, Kartik Chandran
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/f8d2de5ecf62478da3f9d3cfafd25d6d
Autor:
Natalia Cheshenko, Jeffrey B. Bonanno, Hans-Heinrich Hoffmann, Rohit K. Jangra, Kartik Chandran, Charles M. Rice, Steven C. Almo, Betsy C. Herold
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/4d1acc8e80fd4e28a655751b6003208d
Autor:
Alev Celikgil, Aldo B. Massimi, Antonio Nakouzi, Natalia G. Herrera, Nicholas C. Morano, James H. Lee, Hyun ah Yoon, Scott J. Garforth, Steven C. Almo
Publikováno v:
PLoS ONE, Vol 18, Iss 2 (2023)
Antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) target multiple epitopes on different domains of the spike protein, and other SARS-CoV-2 proteins. We developed a SARS-CoV-2 multi-antigen protein microarray with the nuc
Externí odkaz:
https://doaj.org/article/f1ec522c18b64e1f81aa68ad0d125881
Autor:
Nicholas C. Morano, Roshelle S. Smith, Victor Danelon, Ryan Schreiner, Uttsav Patel, Natalia G. Herrera, Carla Smith, Steven M. Olson, Michelle K. Laerke, Alev Celikgil, Scott J. Garforth, Sarah C. Garrett-Thomson, Francis S. Lee, Barbara L. Hempstead, Steven C. Almo
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 22 (2022)
Cell surface receptors, ligands, and adhesion molecules underlie development, circuit formation, and synaptic function of the central nervous system and represent important therapeutic targets for many neuropathologies. The functional contributions o
Externí odkaz:
https://doaj.org/article/62d978590f1d48d48cbcde540b76679b
Autor:
Ronald D. Seidel, Zohra Merazga, Dharma Raj Thapa, Jonathan Soriano, Emily Spaulding, Ahmet S. Vakkasoglu, Paige Ruthardt, Wynona Bautista, Steven N. Quayle, Peter A. Kiener, Simon Low, John F. Ross, Saso Cemerski, Anish Suri, Steven C. Almo, Rodolfo J. Chaparro
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Targeted pharmacologic activation of antigen-specific (AgS) T cells may bypass limitations inherent in current T cell-based cancer therapies. We describe two immunotherapeutics platforms for selective delivery of costimulatory ligands and pe
Externí odkaz:
https://doaj.org/article/897c1421d763409b9b5cd4b0353c9706