Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Steven C Wang"'
Autor:
Gretchen Ehrenkaufer, Pengyang Li, Erin E Stebbins, Monica M Kangussu-Marcolino, Anjan Debnath, Corin V White, Matthew S Moser, Joseph DeRisi, Jolyn Gisselberg, Ellen Yeh, Steven C Wang, Ana Hervella Company, Ludovica Monti, Conor R Caffrey, Christopher D Huston, Bo Wang, Upinder Singh
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0008150 (2020)
Parasitic infections are a major source of human suffering, mortality, and economic loss, but drug development for these diseases has been stymied by the significant expense involved in bringing a drug though clinical trials and to market. Identifica
Externí odkaz:
https://doaj.org/article/4bb14f212d8f4c10b283b6aa6e0db146
Autor:
Steven C Wang, William H. Gerwick, Brian M. Suzuki, Anh P. Ta, Derek A. Wong, Christopher B. Lietz, Nelly El-Sakkary, Guy S. Salvesen, Anthony J. O’Donoghue, Conor R. Caffrey, Zhenze Jiang, Betsaida Bibo-Verdugo, Jehad Almaliti, Vivian Hook
Publikováno v:
ACS Infectious Diseases. 5:1802-1812
Proteases are fundamental to successful parasitism, including that of the schistosome flatworm parasite, which causes the disease schistosomiasis in 200 million people worldwide. The proteasome is receiving attention as a potential drug target for tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb4880ce28abde7c8df38798386a4703
https://doi.org/10.1021/acsinfecdis.9b00237
https://doi.org/10.1021/acsinfecdis.9b00237
Autor:
Adam Conn, Faezeh Ghazi, Assael A. Madrigal, Arturo Medrano-Soto, Pauldeen Davejan, Milton H. Saier, Ida Javadi-Razaz, Kevin J. Hendargo, Daniel C. Yee, Steven C Wang, Katie Jing Kay Lam, Amy Chou
Publikováno v:
Biochimica et biophysica acta. Biomembranes, vol 1862, iss 9
Biochim Biophys Acta Biomembr
Biochim Biophys Acta Biomembr
The Major Facilitator Superfamily (MFS) is currently the largest characterized superfamily of transmembrane secondary transport proteins. Its diverse members are found in essentially all organisms in the biosphere and function by uniport, symport, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d34ff4bb97041f492a11ba1bd9b12c5
https://escholarship.org/uc/item/5bg654qk
https://escholarship.org/uc/item/5bg654qk
Autor:
Alexey V. Melnik, Francesca Di Ottavio, Carlos Molina-Santiago, Jacob M. Wozniak, Anaamika Campeau, Daniel Petras, Kyo Bin Kang, Jehad Almaliti, Morgan Panitchpakdi, Steven C Wang, Robert A. Quinn, Irina Koester, Nuno Bandeira, Katharina Spengler, Brian Kwan, Gajender Aleti, Alexander A. Aksenov, Fernando Vargas, Yueying Li, Kelly C. Weldon, Jie Li, Xavier Holmes, Bohan Ni, Aaron L. Oom, Elizabeth Brown, Rama Chaar, Lingjing Jiang, Ricardo Silva, Alison Vrbanac, Emmanuel O. Elijah, Bahar Teke, Pieter C. Dorrestein, Kayla Wilson, Madeleine Ernst, Anupriya Tripathi, Amina Bouslimani, Michael Yoon, Justin J. J. van der Hooft, Christine M. Aceves, Alyssa M. Demko, Nicole Sikora, Anthony Q. Vu, Julia M. Gauglitz, Andrés Mauricio Caraballo-Rodríguez, Sabah Ul-Hasan, Alan K. Jarmusch, L. Paige Ferguson
Publikováno v:
Food Chemistry, 302
Food Chemistry 302 (2020)
Food Chemistry 302 (2020)
In our daily lives, we consume foods that have been transported, stored, prepared, cooked, or otherwise processed by ourselves or others. Food storage and preparation have drastic effects on the chemical composition of foods. Untargeted mass spectrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00b2d8f8476b30588157d87616ba2c9
https://research.wur.nl/en/publications/untargeted-mass-spectrometry-based-metabolomics-approach-unveils-
https://research.wur.nl/en/publications/untargeted-mass-spectrometry-based-metabolomics-approach-unveils-
Autor:
Glaécia An, Pereira, Lucianna H, Santos, Steven C, Wang, Luan C, Martins, Filipe S, Villela, Weiting, Liao, Marco A, Dessoy, Luiz C, Dias, Adriano D, Andricopulo, Mariana Af, Costa, Ronaldo Ap, Nagem, Conor R, Caffrey, Klaus R, Liedl, Ernesto R, Caffarena, Rafaela S, Ferreira
Publikováno v:
Future Med Chem
AIM: Limitations in available therapies for trypanosomiases indicate the need for improved medicines. Cysteine proteases cruzain and rhodesain are validated targets for treatment of Chagas disease and human African trypanosomiasis. Previous studies r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2ddd0ebb897e8a9f6f930793cb7fd282
https://pubmed.ncbi.nlm.nih.gov/31469332
https://pubmed.ncbi.nlm.nih.gov/31469332
Autor:
Betsaida, Bibo-Verdugo, Steven C, Wang, Jehad, Almaliti, Anh P, Ta, Zhenze, Jiang, Derek A, Wong, Christopher B, Lietz, Brian M, Suzuki, Nelly, El-Sakkary, Vivian, Hook, Guy S, Salvesen, William H, Gerwick, Conor R, Caffrey, Anthony J, O'Donoghue
Publikováno v:
ACS Infect Dis
Proteases are fundamental to successful parasitism, including for the schistosome flatworm parasite, which causes the disease schistosomiasis in 200 million people worldwide. The proteasome is receiving attention as a potential drug target for treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3937e6b795ca2297d53833ec22b25539
https://pubmed.ncbi.nlm.nih.gov/31355632
https://pubmed.ncbi.nlm.nih.gov/31355632
Autor:
Jehad Almaliti, Steven C Wang, Betsaida Bibo-Verdugo, Shoun Matsuka, Anthony J. O’Donoghue, Conor R. Caffrey, Douglas E. Zuill, Lars Eckmann, Justin Yang, Zhenze Jiang, Yukiko Miyamoto, William H. Gerwick
Publikováno v:
Antimicrobial agents and chemotherapy. 63(11)
Trichomoniasis is a sexually transmitted disease with hundreds of millions of annual cases worldwide. Approved treatment options are limited to two related nitro-heterocyclic compounds, yet resistance to these drugs is an increasing concern. New anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e38e223510ee185c477a27b7757f297
https://pubmed.ncbi.nlm.nih.gov/31451503
https://pubmed.ncbi.nlm.nih.gov/31451503
Autor:
Steven C Wang, Ernesto Raul Caffarena, Adriano D. Andricopulo, Marco A. Dessoy, Lucianna Helene Santos, Mariana Af Costa, Ronaldo Ap Nagem, Rafaela Salgado Ferreira, Glaécia An Pereira, Conor R. Caffrey, Weiting Liao, Luan Carvalho Martins, Luiz C. Dias, Klaus R. Liedl, Filipe Silva Villela
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Aim: Limitations in available therapies for trypanosomiases indicate the need for improved medicines. Cysteine proteases cruzain and rhodesain are validated targets for treatment of Chagas disease and human African trypanosomiasis. Previous studies r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78c8d28e853db3915cf7a3bf92fb441
Autor:
Elena Arutyunova, John D. Lapek, Zhenze Jiang, David Gonzalez, Jacob M. Wozniak, M. Joanne Lemieux, Steven C Wang, Anthony J. O’Donoghue
Publikováno v:
Mol Cell Proteomics
Proteolysis is an integral component of life and has been implicated in many disease processes. To improve our understanding of peptidase function, it is imperative to develop tools to uncover substrate specificity and cleavage efficiency. Here, we c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77e5d4c1b2c5213003bac9e577773ff
https://pubmed.ncbi.nlm.nih.gov/30705125
https://pubmed.ncbi.nlm.nih.gov/30705125
Autor:
Amos B. Smith, Ludovica Monti, Steven C Wang, Killian Oukoloff, Carlo Ballatore, Conor R. Caffrey, Kurt R. Brunden
Publikováno v:
ChemMedChem, vol 13, iss 17
In vitro whole-organism screens of Trypanosoma brucei with representative examples of brain-penetrant microtubule (MT)-stabilizing agents identified lethal triazolopyrimidines and phenylpyrimidines with sub-micromolar potency. In mammalian cells, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a063cd630ed78b626dfe100d4d02ba9
https://escholarship.org/uc/item/7hs264h0
https://escholarship.org/uc/item/7hs264h0