Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Steven C Ley"'
Autor:
Alejandra Escós, Ester Diaz-Mora, Michael Pattison, Pilar Fajardo, Diego González-Romero, Ana Risco, José Martín-Gómez, Éric Bonneil, Nahum Sonenberg, Seyed Mehdi Jafarnejad, Juan José Sanz-Ezquerro, Steven C Ley, Ana Cuenda
Publikováno v:
eLife, Vol 12 (2023)
Evidence implicating p38γ and p38δ (p38γ/p38δ) in inflammation are mainly based on experiments using Mapk12/Mapk13-deficient (p38γ/δKO) mice, which show low levels of TPL2, the kinase upstream of MKK1–ERK1/2 in myeloid cells. This could obscu
Externí odkaz:
https://doaj.org/article/465cca0c4aa64ff59473c25390cfe9f4
Autor:
Joan Manils, Louise V Webb, Ashleigh Howes, Julia Janzen, Stefan Boeing, Anne M Bowcock, Steven C Ley
Publikováno v:
eLife, Vol 9 (2020)
To investigate how the CARD14E138A psoriasis-associated mutation induces skin inflammation, a knock-in mouse strain was generated that allows tamoxifen-induced expression of the homologous Card14E138A mutation from the endogenous mouse Card14 locus.
Externí odkaz:
https://doaj.org/article/5715b3c4645845bc95c4bf269c9d74b7
Autor:
Yashaswini Kannan, Lewis J Entwistle, Victoria S Pelly, Jimena Perez-Lloret, Alan W Walker, Steven C Ley, Mark S Wilson
Publikováno v:
PLoS Pathogens, Vol 13, Iss 7, p e1006536 (2017)
TPL-2 (COT, MAP3K8) kinase activates the MEK1/2-ERK1/2 MAPK signaling pathway in innate immune responses following TLR, TNFR1 and IL-1R stimulation. TPL-2 contributes to type-1/Th17-mediated autoimmunity and control of intracellular pathogens. We rec
Externí odkaz:
https://doaj.org/article/f642179410e741b1a6bfc7545795a5e5
Autor:
Yashaswini Kannan, Jimena Perez-Lloret, Yanda Li, Lewis J Entwistle, Hania Khoury, Stamatia Papoutsopoulou, Radma Mahmood, Nuha R Mansour, Stanley Ching-Cheng Huang, Edward J Pearce, Luiz Pedro S de Carvalho, Steven C Ley, Mark S Wilson
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005783 (2016)
Persistent TH2 cytokine responses following chronic helminth infections can often lead to the development of tissue pathology and fibrotic scarring. Despite a good understanding of the cellular mechanisms involved in fibrogenesis, there are very few
Externí odkaz:
https://doaj.org/article/9e27add65ae847c1a7c1fa12789084b2
Autor:
Alejandra Escós, Ester Díaz-Mora, Michael Pattison, Pilar Fajardo, Diego González-Romero, Ana Risco, José Martín-Gómez, Éric Bonneil, Nahum Sonenberg, Seyed Mehdi Jafarnejad, Juan José Sanz-Ezquerro, Steven C. Ley, Ana Cuenda
Evidence implicating p38γ and p38δ (p38γ/p38δ) in inflammation are mainly based on experiments using p38γ/p38δ deficient (p38γ/δ-/-) mice, which show low levels of TPL2, the kinase upstream of MKK1-ERK1/2 in myeloid cells. This could obscure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72e4f49d4069c6219b194e7fdd582af3
https://doi.org/10.1101/2022.12.09.519777
https://doi.org/10.1101/2022.12.09.519777
Autor:
Simon Rousseau, Matoula Papoutsopoulou, Antony Symons, Dorthe Cook, John M. Lucocq, Alan R. Prescott, Anne O'Garra, Steven C. Ley, Philip Cohen
Publikováno v:
Journal of Cell Science. 135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e04e06f4a84711a61e6baca72df206bd
https://doi.org/10.1242/jcs.260708
https://doi.org/10.1242/jcs.260708
Autor:
Helen R. Flynn, Tiaan Heunis, Steven C. Ley, Teresa L. M. Thurston, Probir Chakravarty, Felix Breyer, Matthias Trost, Julia Janzen, Anetta Härtlova, Ambrosius P. Snijders, Julien Peltier
Publikováno v:
The EMBO Journal
Tumour progression locus 2 (TPL‐2) kinase mediates Toll‐like receptor (TLR) activation of ERK1/2 and p38α MAP kinases in myeloid cells to modulate expression of key cytokines in innate immunity. This study identified a novel MAP kinase‐indepen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8efa290772669611e7bc2c8f755856e7
https://doi.org/10.15252/embj.2020106188
https://doi.org/10.15252/embj.2020106188
Autor:
Felix Breyer, Mark S. Wilson, Florencia Cano, Yashaswini Kannan, Sonia Ventura, Steven C. Ley, Michael J. Pattison
Publikováno v:
The Journal of Experimental Medicine
Airway allergic responses are shown to be inhibited by binding of ABIN-2 to A20, a key negative regulator of inflammation. In contrast, the catalytic activity of the ABIN-2–associated kinase TPL-2 does not regulate airway allergic responses, an imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11996a0372aedaab5e83da98195b0119
https://doi.org/10.1084/jem.20170852
https://doi.org/10.1084/jem.20170852
Autor:
Svend Kjaer, Michael J. Pattison, Yasmina Soneji, David J. Powell, Steven C. Ley, Bill Leavens, Chao-Sheng Chen, David House, Carl Haslam, Probir Chakravarty, Sandra Kümper, Thorsten Gantke, Daniel Thomas
Publikováno v:
Biochemical Journal
The MKK1/2 kinase tumour progression locus 2 (TPL-2) is critical for the production of tumour necrosis factor alpha (TNFα) in innate immune responses and a potential anti-inflammatory drug target. Several earlier pharmaceutical company screens with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a8694e5fd527b9a14660fdb7874aae
https://doi.org/10.1042/bcj20170579
https://doi.org/10.1042/bcj20170579