Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Steven C, Katz"'
Autor:
Diwakar Davar, Yujia Liu, Jason Laporte, Prajna Guha, Steven C Katz, Chandra C Ghosh, Lauren Cournoyer, Alizee Ballarin, Ilan B Layman, Molly Morrissey, Kayla Fraser, Shriya Perati, Bryan F Cox, Evgeny Yakirevich, Diana O Treaba, Timothy D Murtha
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background Toll-like receptor 9 (TLR9) agonists induce inflammatory responses that promote the killing of infectious micro-organisms, cancer cells and develop adaptive immune responses. Their ability as immunomodulators to enhance the activity of che
Externí odkaz:
https://doaj.org/article/a44effbe99ed410eaeba499fe1a1625d
Autor:
Nicholas A. DaSilva, Benjamin J. Barlock, Prajna Guha, Chandra C. Ghosh, Catherine E. Trebino, Jodi L. Camberg, Steven C. Katz, David C. Rowley
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Myeloid-derived suppressor cells (MDSCs) promote immunosuppressive activities in the tumor microenvironment (TME), resulting in increased tumor burden and diminishing the anti-tumor response of immunotherapies. While primary and metastatic t
Externí odkaz:
https://doaj.org/article/bb926099cfb648d1a8e9534e9ec798c2
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 655 (2022)
With the advent of cancer immunotherapy, there has been a major improvement in patient’s quality of life and survival. The growth of cancer immunotherapy has dramatically changed our understanding of the basics of cancer biology and has altered the
Externí odkaz:
https://doaj.org/article/6932c94d40064453b8e66d159588033a
Autor:
Mirela Stancu, Robert Knight, Jason Laporte, Prajna Guha, Steven C Katz, Jill E Slansky, Ashley E Moody, John C Hardaway, Ethan Prince, Kimberly R Jordan, Richard D Schulick, Abdul Saied, Vincent Armenio, Richard P Junghans
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
In recent years, cell therapy technologies have resulted in impressive results in hematologic malignancies. Treatment of solid tumors with chimeric antigen receptor T-cells (CAR-T) has been less successful. Solid tumors present challenges not encount
Externí odkaz:
https://doaj.org/article/5118535cc9e842ce850a0e39b1929165
Autor:
Louis F. Chai, John C. Hardaway, Kara R. Heatherton, Kyle P. O’Connell, Mikayla C. Lopes, Benjamin A. Rabinowitz, Chandra C. Ghosh, Prajna Guha, David Jaroch, Bryan F. Cox, Steven C. Katz
Publikováno v:
Vaccines, Vol 9, Iss 8, p 807 (2021)
Metastatic liver tumors have presented challenges with the use of checkpoint inhibitors (CPIs), with only limited success. We hypothesize that regional delivery (RD) of CPIs can improve activity in the liver and minimize systemic exposure, thereby re
Externí odkaz:
https://doaj.org/article/6fb5f456cae4492f8c6c1e505c93455d
Autor:
Chandra C. Ghosh, Kara R. Heatherton, Kyle P. O’ Connell, Ian S. Alexander, Deborah A. Greer, Jason LaPorte, Prajna Guha, Bryan F. Cox, Steven C. Katz
Publikováno v:
Cancer Gene Therapy. 29:1854-1865
Myeloid-derived suppressor cells (MDSCs) expand in response to malignancy and suppress responsiveness to immunotherapy, including checkpoint inhibitors (CPIs). Within the liver, MDSCs have unique immunosuppressive features. While TLR9 agonists have s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43ccd38fbf84598e7fc2d4be9075680
https://doi.org/10.1038/s41417-022-00484-z
https://doi.org/10.1038/s41417-022-00484-z
Autor:
Ronald P. DeMatteo, Michael I. D'Angelica, Yuman Fong, Peter J. Allen, T. Peter Kingham, William R. Jarnagin, Jinru Shia, Steven C. Katz, Simon Turcotte
PDF file - 182K, Table S1 shows the correlation between all immune markers expression tested; Table S2 shows the lack of correlation between the favorable immune score and clinicopathologic characteristics. Figure S1 illustrates the quantification me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f133de6887ad6d795b9dde3cb424b70
https://doi.org/10.1158/2326-6066.22537289.v1
https://doi.org/10.1158/2326-6066.22537289.v1
Autor:
Ronald P. DeMatteo, Michael I. D'Angelica, Yuman Fong, Peter J. Allen, T. Peter Kingham, William R. Jarnagin, Jinru Shia, Steven C. Katz, Simon Turcotte
Tumor-infiltrating lymphocytes (TIL) in colorectal cancer liver metastases (CLM) have been associated with more favorable patient outcomes, but whether MHC class I (MHC-I) expression on cancer cells affects prognosis is uncertain. Immunohistochemistr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc97e927e5ed43449b0152e3fc6dc825
https://doi.org/10.1158/2326-6066.c.6548381.v1
https://doi.org/10.1158/2326-6066.c.6548381.v1
Autor:
Richard P. Junghans, N. Joseph Espat, Robin Davies, Earle O. Assanah, Brian F. Stainken, Qiangzhong Ma, Mitchell Thorn, Pranay D. Khare, Gary R. Point, Wesley Mooring, Li Juan Wang, Elise McCormack, Rachel A. Burga, Steven C. Katz
Supplemental Figure 1. In vitro cytotoxicity assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e4f36b3128e8a08781410abb288250
https://doi.org/10.1158/1078-0432.22458323
https://doi.org/10.1158/1078-0432.22458323
Autor:
Richard P. Junghans, N. Joseph Espat, Robin Davies, Earle O. Assanah, Brian F. Stainken, Qiangzhong Ma, Mitchell Thorn, Pranay D. Khare, Gary R. Point, Wesley Mooring, Li Juan Wang, Elise McCormack, Rachel A. Burga, Steven C. Katz
Purpose: Chimeric antigen receptor–modified T cells (CAR-T) have demonstrated encouraging results in early-phase clinical trials. Successful adaptation of CAR-T technology for CEA-expressing adenocarcinoma liver metastases, a major cause of death i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c749b8413a71355a55dddb9a20c880e
https://doi.org/10.1158/1078-0432.c.6523904.v1
https://doi.org/10.1158/1078-0432.c.6523904.v1