Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation.

Autor: Valentina Sanghez, Anna Luzzi, Don Clarke, Dustin Kee, Steven Beuder, Danielle Rux, Mitsujiro Osawa, Joaquín Madrenas, Tsui-Fen Chou, Michael Kyba, Michelina Iacovino

Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0186818 (2017)

Hemogenic endothelium (HE) undergoes endothelial-to-hematopoietic transition (EHT) to generate blood, a process that requires progressive down-regulation of endothelial genes and induction of hematopoietic ones. Previously, we have shown that the tra

Externí odkaz: https://doaj.org/article/cbbdf91f80c6484ea0168b76418e3943

Phospholipase C6 Regulates HydroxyprolineO-arabinosyltransferase-mediated Pollen Tube Growth inArabidopsis

Autor: Steven Beuder, Xuesi Hua, Alexandria Dorchak, Cora A. MacAlister

HydroxyprolineO-arabinosylation is a highly-conserved and plant-specific post-translational modification found on extensins and other structural proteins in the cell wall, and is catalyzed by HydroxyprolineO-arabinosyltransferases (HPATs). InArabidop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2fed9f61a1da93b7971d18e3b234ffc
https://doi.org/10.1101/2022.10.26.513895

Isolation and Cloning of Suppressor Mutants with Improved Pollen Fertility

Autor: Steven, Beuder, Cora A, MacAlister

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2160

Mutant screens remain among the most powerful unbiased methods for identifying key genes in a pathway or process of interest. However, mutants impacting pollen function pose special challenges due to their genetic behavior. Here we describe an approa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0fbbeae1648440703ace246d443e9c3a
https://pubmed.ncbi.nlm.nih.gov/32529431

Exocyst mutants suppress pollen tube growth and cell wall structural defects ofhydroxyproline O-arabinosyltransferasemutants

Autor: Alexandria E. Dorchak, Svenning Rune Moeller, Steven Beuder, Cora A. MacAlister, Ashwini Bhide, Bent O. Petersen

Publikováno v: Beuder, S, Dorchak, A, Bhide, A, Moeller, S R, Petersen, B L & MacAlister, C A 2020, ' Exocyst mutants suppress pollen tube growth and cell wall structural defects ofhydroxyproline O-arabinosyltransferasemutants ', Plant Journal, vol. 103, no. 4, pp. 1399-1419 . https://doi.org/10.1111/tpj.14808
The Plant Journal

Summary HYDROXYPROLINE O‐ARABINOSYLTRANSFERASEs (HPATs) initiate a post‐translational protein modification (Hyp‐Ara) found abundantly on cell wall structural proteins. In Arabidopsis thaliana, HPAT1 and HPAT3 are redundantly required for full p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0804ec09c89ca3e3624f93992eba7ec2
https://curis.ku.dk/portal/da/publications/exocyst-mutants-suppress-pollen-tube-growth-and-cell-wall-structural-defects-ofhydroxyproline-oarabinosyltransferasemutants(b2cfb41a-26b1-44e9-a3a7-da0ce0f5b5b2).html

HoxA3 Controls Notch Pathway to Repress Blood Development

Autor: Michael Kyba, Danielle Rux, Valentina Sanghez, Michael B. Elowitz, Joe Markson, Mitsujiro Osawa, Steven Beuder, Michelina Iacovino, Dustin Kee

Publikováno v: Blood. 124:4338-4338

Hematopoietic stem cells (HSC) are generated from a specialized subset of endothelial cells, hemogenic endothelium. Previous studies performed by our group showed that HoxA3 restrains the cell at the hemogenic endothelium stage, inhibiting further di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dacda12461fc569e7cb5842454151965
https://doi.org/10.1182/blood.v124.21.4338.4338