Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Steven B. Walls"'
Autor:
Simon J F, Macdonald, Geoffrey D E, Clarke, Michael D, Dowle, Lee A, Harrison, Simon T, Hodgson, Graham G A, Inglis, Martin R, Johnson, Prit, Shah, Richard J, Upton, Steven B, Walls
Publikováno v:
The Journal of organic chemistry. 64(14)
A flexible, practical, and stereoselective synthesis of enantiomerically pure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd9b13ef74f72d85e684fd8ce230d565
https://pubmed.ncbi.nlm.nih.gov/34237863
https://pubmed.ncbi.nlm.nih.gov/34237863
Publikováno v:
European Journal of Organic Chemistry. 2006:323-327
Fused carbocyclic systems containing seven- and eight-membered rings can be constructed from allylic ethers in a stereoselective manner by tandem carbenoid generation, ylide formation and [2,3] rearrangement. Exceptionally high yields are obtained in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24edaee7aab542f67b5d55733f940de1
https://doi.org/10.1002/ejoc.200500830
https://doi.org/10.1002/ejoc.200500830
Autor:
Simon J. F. Macdonald, Geoffrey D. Clarke, Michael Dennis Dowle, Martin R. Johnson, Graham G. A. Inglis, Prit Shah, Richard J. Upton, Lee Andrew Harrison, Steven B. Walls, Simon Teanby Hodgson
Publikováno v:
The Journal of Organic Chemistry. 64:5166-5175
A flexible, practical, and stereoselective synthesis of enantiomerically pure trans-5-oxohexahydropyrrolo[3,2-b]pyrroles (pyrrolidine-trans-lactams) is described. The key reaction involves addition of Z-ketene acetal 24 to the acyliminium ion derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfdecc5945718a25fd9ebfc3ecb553de
https://doi.org/10.1021/jo990306s
https://doi.org/10.1021/jo990306s
Autor:
Hart Terance William, Rachel Parsons, Ben Gibbons, Helen Browne, Macias Alba, Heather Simmonite, Sarah Dugdale, Sean Lightowler, Howard Langh Am Mansell, Guy A. Kennett, Anthony Padfield, Geraint L. Francis, Robert M. Pratt, Teresa Brooks, Timothy Haymes, Jalanie D’Alessandro, Natalia Matassova, K Benwell, Melanie Wong, Steven B. Walls, Stephen D. Roughley, A Misra, Zoe Daniels, Angela Merrett, Alan D. Robertson, Kiri Tan
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(2)
We describe here our attempts to optimise the human fatty acid amide hydrolase (FAAH) inhibition and physicochemical properties of our previously reported tetrasubstituted azetidine urea FAAH inhibitor, VER-156084. We describe the SAR of a series of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1ef0471571a1b51d463d6743f77c74
https://pubmed.ncbi.nlm.nih.gov/22209458
https://pubmed.ncbi.nlm.nih.gov/22209458
Autor:
Brian Dymock, Allan E. Surgenor, Joseph Schoepfer, Christophe Fromont, Carlos Garcia-Echeverria, Suzanne A. Eccles, Angela Hayes, Melanie Valenti, Paul Brough, Angela Merrett, Roderick E. Hubbard, Nicholas G. M. Davies, Martin J. Drysdale, Michael Rugaard Jensen, Heather Simmonite, Thomas Radimerski, Andrew Massey, Allan M. Jordan, Alan D. Robertson, Michael Wood, Lisa Wright, Patrick Chène, Florence I. Raynaud, Paul Webb, Steven B. Walls, Swee Y. Sharp, Paul Workman, Ben Davis, Xavier Barril, Antony Padfield, Stephen D. Roughley, Rachel Parsons, Jenifer Borgognoni
Publikováno v:
Journal of medicinal chemistry. 52(15)
Inhibitors of the Hsp90 molecular chaperone are showing considerable promise as potential molecular therapeutic agents for the treatment of cancer. Here we describe novel 2-aminothieno[2,3-d]pyrimidine ATP competitive Hsp90 inhibitors, which were des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6259b30e505d42781708a3bb781d7d0
https://pubmed.ncbi.nlm.nih.gov/19610616
https://pubmed.ncbi.nlm.nih.gov/19610616
Autor:
Alan Robertson, Guy A. Kennett, Stephen D. Roughley, Geraint L. Francis, K Benwell, Melanie Wong, Rachel Parsons, A Misra, Timothy Haymes, Hart Terance William, Howard Langh Am Mansell, Macias Alba, Anthony Padfield, Sean Lightowler, Jalanie D’Alessandro, Natalia Matassova, Ben Gibbons, Teresa Brooks, Steven B. Walls, Robert M. Pratt, Pawel Dokurno
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
We report the discovery of a novel, chiral azetidine urea inhibitor of Fatty Acid Amide Hydrolase (FAAH,) and describe the surprising species selectivity of VER-156084 versus rat and human FAAH and also hCB1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da69bc0152d4e578d01cb7c6a1e224e
https://pubmed.ncbi.nlm.nih.gov/19515560
https://pubmed.ncbi.nlm.nih.gov/19515560