Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Steven B. Thorpe"'
Autor:
Kevin R. Lynch, Jose L. Tomsig, Molly D. Congdon, Steven B. Thorpe, Yugesh Kharel, Emily A. Morris, Webster L. Santos
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 355:23-31
Sphingosine 1-phosphate (S1P) levels are significantly higher in blood and lymph than in tissues. This S1P concentration difference is necessary for proper lymphocyte egress from secondary lymphoid tissue and to maintain endothelial barrier integrity
Publikováno v:
Organic Letters. 14:1918-1921
Using bis(pinacolato)diboron, catalytic amounts of Cu(II), and various amine bases in water under atmospheric conditions at rt, acyclic and cyclic α,β-unsaturated ketones and esters are β-borylated in up to 98% yield. Mechanistic investigations us
Publikováno v:
Organic Letters. 11:3478-3481
A novel sp(2)-sp(3) hybridized mixed diboron and its reactivity on the copper-catalyzed beta-boration of alpha,beta-unsaturated conjugated compounds to afford the corresponding beta-borated compounds is reported. The presence of sp(3)-hybridized boro
Publikováno v:
Chem. Commun.. 47:424-426
A mild and efficient copper-catalyzed borylation of electron deficient allenoates using an sp(2)-sp(3) mixed hybridized diboron regioselectively installs a boron moiety on the β-position with exclusive (Z)-double bond geometry.
Autor:
Webster L. Santos, Steven B. Thorpe
Publikováno v:
e-EROS Encyclopedia of Reagents for Organic Synthesis
[1175712-33-0, 1177425-14-7, 1262977-13-8, 1303527-12-9] C12H25B2NO4 (MW 268.95) InChI = S/C12H25B2NO4/c1-9-7-15-8-10(2)17-13(16-9)14-18-11(3,4)12(5,6)19-14/h9-10,15H,7-8H2,1-6H3 InChIKey = IGLQSAGCEMHFPH-UHFFFAOYSA-N (reagent used as a boron source,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8ba25daa500c95b24cb712cab469af9
https://doi.org/10.1002/047084289x.rn01517
https://doi.org/10.1002/047084289x.rn01517
Publikováno v:
ChemInform. 43
Unexpectedly simple conditions are developed which render possible the β-borylation of a variety of α,β-unsaturated carbonyl compounds.
Autor:
Steven B. Thorpe, Christian Kleeberg, Webster L. Santos, Todd B. Marder, Ming Gao, Carla Slebodnick
Publikováno v:
ChemInform. 42
The diborane (II) is an efficient reagent for the Cu-catalyzed β-boration of various α,β-unsaturated ketones, aldehydes, esters, amides, and nitriles to produce synthetically important organo-boron compounds.
Publikováno v:
ChemInform. 42
Mild and efficient copper-catalyzed borylation of electron-deficient allenoates (I) using the sp2-sp3 mixed hybridized diboron compound (II) regioselectively installs a boron moiety on the β-position with complete stereocontrol.
Publikováno v:
ChemInform. 40
Publikováno v:
Organic & Biomolecular Chemistry. 8:3451
The synthesis and development of N-terminal peptidic boronic acids as protease inhibitors is reported. N-Terminal peptidic boronic acids interrogate the S' sites of the target protein for selectivity and provide a new strategy that complements the cu