Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Steven B Sands"'
Autor:
Ann J. Barbier, Steven B Sands, Lilian Y Li, Anthony Ndifor, Chandra R. Shah, Kirsten L. Morton, Michael A. Letavic, Timothy W. Lovenberg, Anne Bonneville, Heather McAllister, Neelakandha S. Mani, Ian Fraser, Kiev S. Ly, Richard Apodaca, Nicholas I. Carruthers, Manoj Bajpai, Swanson Devin M, Michelle Kramer, Christine Dugovic, Sandra S Snook, Chennagiri R. Pandit, Jonathan Shelton, Wei Xiao, Leah Aluisio, Pascal Bonaventure, Brian Lord, S Diane Nepomuceno
Publikováno v:
ACS Medicinal Chemistry Letters. 6:450-454
The preclinical characterization of novel phenyl(piperazin-1-yl)methanones that are histamine H3 receptor antagonists is described. The compounds described are high affinity histamine H3 antagonists. Optimization of the physical properties of these h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb111c3b07b944a678c3abee290cc57f
https://doi.org/10.1021/ml5005156
https://doi.org/10.1021/ml5005156
Autor:
Amy B. Jakowski, F. David Tingley, Amy C. Shen, Michael R. Elwell, Steven B. Sands, Jenny Hon Cai, Martin Finkelstein, Dominique Brees
Publikováno v:
Toxicologic Pathology. 36:568-575
In a two-year carcinogenicity study with administration of high doses of the partial nicotinic agonist varenicline (recently approved for smoking cessation), mediastinal hibernomas occurred in three male rats. To investigate potential mechanisms for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf654145518842d89ea4bfe52f352b95
https://doi.org/10.1177/0192623308317424
https://doi.org/10.1177/0192623308317424
Autor:
Arneric Sp, Karen K. Cook, Thomas J. Raub, Bruce N. Rogers, Mark L. Wolfe, Eric Jon Jacobsen, Vincent E. Groppi, Carey G, Brian A. Staton, Daniel P. Walker, Raymond S. Hurst, Luz A. Cortes-Burgos, Rodney R. Walters, Donn G. Wishka, Theron M. Wall, Jia S, Hanchar Aj, Karen M. Yates, Steven B. Sands, Bruce A. Thornburgh, Gold Lh, Soglia, Jason K. Myers, Franklin S, Steven Charles Reitz, Sabrina X. Zhao, Amit S. Kalgutkar, Nicole R. Higdon, Olson Kl, Erik H. F. Wong, Mihály Hajós, William E. Hoffmann
Publikováno v:
Journal of Medicinal Chemistry. 49:4425-4436
N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide (14, PHA-543,613), a novel agonist of the alpha7 neuronal nicotinic acetylcholine receptor (alpha7 nAChR), has been identified as a potential treatment of cognitive deficits in sch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09fbbbb19eb89de61edd6e606a68da00
https://doi.org/10.1021/jm0602413
https://doi.org/10.1021/jm0602413
Autor:
Thomas I. Davis, Carol B. Fox, Michael C. Wirtz, Michael G. Vetelino, F. David Tingley, Krista E. Bianco, Robert S. Mansbach, David W. Schulz, Jotham Wadsworth Coe, Crystal G. Bashore, Hans Rollema, Eric P. Arnold, Paige Roanne Palmer Brooks, Steven B. Sands, Brian T. O’Neill, Lorraine A. Lebel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4889-4897
3,5-Bicyclic aryl piperidines are a new class of high-affinity alpha4beta2 nicotinic receptor agents. We have sought nicotinic receptor partial agonists of the alpha4beta2 nicotinic acetylcholine receptor for smoking cessation, and a number of compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04dfd8d682666f8daba933d872fb0b4a
https://doi.org/10.1016/j.bmcl.2005.08.035
https://doi.org/10.1016/j.bmcl.2005.08.035
Autor:
Yi Lu, Jotham Wadsworth Coe, Thomas I. Davis, David W. Schulz, Lorraine A. Lebel, Robert S. Mansbach, Paige Roanne Palmer Brooks, Michael C. Wirtz, Alka Shrikhande, Michael G. Vetelino, Leslie K. Chambers, Eric P. Arnold, Eric Schaeffer, Brian T. O’Neill, Steven B. Sands, and F. David Tingley, James Heym, Carol B. Fox, Huang Jianhua, Charles C. Rovetti, Hans Rollema
Publikováno v:
Modern Drug Synthesis
Herein we describe a novel series of compounds from which varenicline (1, 6,7,8,9-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine) has been identified for smoking cessation. Neuronal nicotinic acetylcholine receptors (nAChRs) mediate the dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d09a810f898eefeb7fda3442e4b30f
https://doi.org/10.1021/jm050069n
https://doi.org/10.1021/jm050069n
Autor:
Steven B. Sands
Publikováno v:
Science. 275:1401-1404
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::157461c0a8f4d2a99a44c48338dacee1
https://doi.org/10.1126/science.275.5305.1401a
https://doi.org/10.1126/science.275.5305.1401a
Autor:
Alka Shrikhande, Eric P. Arnold, Lorraine A. Lebel, Langu Peng, Frank M. Nedza, Brian T. O’Neill, Douglas K. Spracklin, Robert J. Mather, Steven B. Sands, Christopher J. O’Donnell
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(16)
The synthesis and SAR studies about the bicyclic amine, carbamate linker and aromatic ring of a 1,4-diazabicyclo[3.2.2]nonane phenyl carbamate series of alpha7 nAChR agonists is described. The development of the medicinal chemistry strategy and SAR w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810702d35a2b08f6f102ead87be5cd61
https://pubmed.ncbi.nlm.nih.gov/19576766
https://pubmed.ncbi.nlm.nih.gov/19576766
Autor:
Michael E. Barish, Steven B. Sands
Publikováno v:
Brain Research. 560:38-42
The conductance properties of neuronal nicotinic acetylcholine receptors (neuronal nAChR channels) in PC12 cells were studied using single channel and whole cell gigaohm seal voltage clamp techniques. Acetylcholine receptor agonists were applied usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb4a1ce493f3b79e1e25731ba78c032
https://doi.org/10.1016/0006-8993(91)91211-i
https://doi.org/10.1016/0006-8993(91)91211-i
Autor:
Steven B. Sands, Leslie K. Chambers, Eric Schaeffer, Raymond S. Hurst, Robert S. Mansbach, J. Glowa, Hans Rollema, F. D. Tingley, Charles C. Rovetti, Yi Lu, David W. Schulz, Robert J. Mather, Jotham Wadsworth Coe, Lorraine A. Lebel, Kathryn E. Williams
Publikováno v:
Neuropharmacology. 52(3)
The preclinical pharmacology of the alpha4beta2 nicotinic acetylcholine receptor (nAChR) partial agonist varenicline, a novel smoking cessation agent is described. Varenicline binds with subnanomolar affinity only to alpha4beta2 nAChRs and in vitro f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923f018ec34038ca039b3bc97c7a5fde
https://pubmed.ncbi.nlm.nih.gov/17157884
https://pubmed.ncbi.nlm.nih.gov/17157884
Autor:
Michael C. Wirtz, Eric P. Arnold, Paige Roanne Palmer Brooks, Michael G. Vetelino, Lorraine A. Lebel, Carol B. Fox, David W. Schulz, Brian T. O’Neill, Crystal G. Bashore, Jotham Wadsworth Coe, Thomas I. Davis, Hans Rollema, Steven B. Sands, F. David Tingley
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(12)
The preparation and biological activity of analogs of (-)-cytisine, an alpha4beta2 nicotinic receptor partial agonist, are discussed. All-carbon-containing phenyl ring replacements of the pyridone ring system, generated via Heck cyclization protocols
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270e8e92215b8f7670e12bf1597706a0
https://pubmed.ncbi.nlm.nih.gov/15908213
https://pubmed.ncbi.nlm.nih.gov/15908213