Tubulin-binding dibenz[c,e]oxepines: Part 2. Structural variation and biological evaluation as tumour vasculature disrupting agents

Autor: Timothy W. Wallace, John A. Hadfield, Steven B. Rossington, Kaye J. Williams, Steven D. Shnyder

Publikováno v: Rossington, S, Hadfield, J, Shnyder, S D, Wallace, T & Williams, K 2017, ' Tubulin-binding dibenz[c,e]oxepines : Part 2. Structural variation and biological evaluation as tumour vasculature disrupting agents ', Bioorganic and Medicinal Chemistry, vol. 25, no. 5, pp. 1630-1642 . https://doi.org/10.1016/j.bmc.2017.01.027

5,7-Dihydro-3,9,10,11-tetramethoxybenz[c,e]oxepin-4-ol 1, prepared from a dibenzyl ether precursor via Pd-catalysed intramolecular direct arylation, possesses broad-spectrum in vitro cytotoxicity towards various tumour cell lines, and induces vascula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7159b0428917a521e7ecb361504f199
https://doi.org/10.1016/j.bmc.2017.01.027

Asymmetric synthesis of diarylmethane derivatives by dynamic kinetic resolution

Autor: James A. Wilkinson, Steven B. Rossington, Lewis M. Gooch

Publikováno v: Tetrahedron Letters. 56:4025-4027

Asymmetric allylation of ortho-methoxydiphenylmethane has been carried out with high yields and ee of up to 94% using the chiral ligand (−)-sparteine as an additive. Results of reactions performed under various conditions suggest that a dynamic kin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3eb30f12b2f85df52547a88ba27ed08
https://doi.org/10.1016/j.tetlet.2015.05.006

Building BORIS – an outreach project on drug design and molecular modelling

Autor: Steven B. Rossington

Publikováno v: The Biochemist. 39:50-51

Within university chemistry departments, organic chemists are formulating reaction pathways which will yield a desired chemical product. In most cases, it is often found that the targeted product exerts some beneficial biological effect towards cellu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bbae69004b2ba09ae6bd7df9b37bf12
https://doi.org/10.1042/bio03902050

ChemInform Abstract: Asymmetric Synthesis of Diarylmethane Derivatives by Dynamic Kinetic Resolution

Autor: Steven B. Rossington, Lewis M. Gooch, James A. Wilkinson

Publikováno v: ChemInform. 46

Using the chiral ligand (-)- sparteine as additive, the asymmetric allylation of ortho-methoxydiphenylmethane (I) is carried out with e.e.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de8ae3b26d098067a90f1535ca7a40b8
https://doi.org/10.1002/chin.201540105

Asymmetric alkylation of N-pivaloyl-o-benzylaniline

Autor: Steven B. Rossington, James A. Wilkinson, Nigel Hussain, John Leonard, Sylvie Ducki

Publikováno v: Tetrahedron: Asymmetry. 15:3011-3013

Alkylation of 2-methoxyethoxyphenyl phenylmethane using sec -BuLi and (−)-sparteine has been carried out in excellent yields and up to 76% ee. The use of O’Brien’s (+)-sparteine surrogate gave the opposite sense of asymmetric induction at 80% e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291ad76a95724edd82a33598c674ccc8
https://doi.org/10.1016/j.tetasy.2004.08.020