Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Steven Albelda"'
Autor:
Cecile Geuijen, Paul Tacken, Liang-Chuan Wang, Rinse Klooster, Pieter Fokko van Loo, Jing Zhou, Arpita Mondal, Yao-bin Liu, Arjen Kramer, Thomas Condamine, Alla Volgina, Linda J. A. Hendriks, Hans van der Maaden, Eric Rovers, Steef Engels, Floris Fransen, Renate den Blanken-Smit, Vanessa Zondag-van der Zande, Abdul Basmeleh, Willem Bartelink, Ashwini Kulkarni, Wilfred Marissen, Cheng-Yen Huang, Leslie Hall, Shane Harvey, Soyeon Kim, Marina Martinez, Shaun O’Brien, Edmund Moon, Steven Albelda, Chrysi Kanellopoulou, Shaun Stewart, Horacio Nastri, Alexander B. H. Bakker, Peggy Scherle, Ton Logtenberg, Gregory Hollis, John de Kruif, Reid Huber, Patrick A. Mayes, Mark Throsby
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The anti-tumour effect of immune checkpoint inhibitors is potentiated by CD137 agonists in preclinical models, but translation of these results to the clinical practice is hampered by toxicity. Authors describe here a human CD137xPD-L1 bispecific ant
Externí odkaz:
https://doaj.org/article/4044cbbb9c1d4937ac08f857eba69b30
Autor:
Nirali Shah, Lili Yang, Kasia Bourcier, Antoni Ribas, Pawel Kalinski, Ke Liu, Phil Greenberg, Carl June, Marcela Maus, Steven Rosenberg, Madhav Dhodapkar, Irina Tiper, Chantale Bernatchez, Michael Hudecek, Stanley Riddell, Stephen Gottschalk, Crystal Mackall, Lisa Butterfield, Greg Delgoffe, Michael Nishimura, Terry Fry, Marc S. Ernstoff, Christopher Klebanoff, Elad Sharon, Malcolm Brenner, Cliona Rooney, Christine Brown, Marc S Ernstoff, Tonya Webb, Magdalena Thurin, Wendell Lim, David Stroncek, Catherine Bollard, Helen Chen, Cameron Turtle, Christian Hinrichs, Laura K Fogli, Rosemarie Aurigemma, Connie L Sommers, Steven Albelda, Renier Brentjens, Yvonne Chen, Laronna Colbert, Kenneth Cornetta, Jason Cristofaro, Thomas Finn, Laura K Fogli Hunter, Alyssa Galaro, Ananda Goldrath, Ray Harris, Lori Henderson, Yuxia Jia, Dan Kaufman, Bruce Levine, Lawrence Lum, Samantha Maragh, Alex Marson, Raj Puri, Jake Reder, Isabelle Riviere, Kole Roybal, Rachelle Salomon, Tal Salz, Barbra Sasu, Andrea Schietinger, Connie L. Sommers, Minkyung Song, Fyodor Urnov, Anthony Welch, Travis Young, Jason Yovandich
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Cell-based immunotherapies have had remarkable success in the clinic, specifically in the treatment of hematologic malignancies. However, these strategies have had limited efficacy in patients with solid tumors. To better understand the challenges in
Externí odkaz:
https://doaj.org/article/f4500c9773db47d7abfb74eccac2d857
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 4 (2016)
Diacylglycerol kinases (DGKs) are a family of enzymes that catalyze the metabolism of diacylglycerol (DAG). Two isoforms of DGK, DGKα and DGKζ, specifically regulate the pool of DAG that is generated as a second messenger after stimulation of the T
Externí odkaz:
https://doaj.org/article/5c7a3a00b6804a20b3511c0d8c0721f9
Intraoperative near-infrared imaging can distinguish cancer from normal tissue but not inflammation.
Autor:
David Holt, Olugbenga Okusanya, Ryan Judy, Ollin Venegas, Jack Jiang, Elizabeth DeJesus, Evgeniy Eruslanov, Jon Quatromoni, Pratik Bhojnagarwala, Charuhas Deshpande, Steven Albelda, Shuming Nie, Sunil Singhal
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103342 (2014)
Defining tumor from non-tumor tissue is one of the major challenges of cancer surgery. Surgeons depend on visual and tactile clues to select which tissues should be removed from a patient. Recently, we and others have hypothesized near-infrared (NIR)
Externí odkaz:
https://doaj.org/article/404cf550f6c041218e755cd83500844a
Autor:
Michael C. Milone, Steven Albelda, Ellen Puré, David Barrett, Michael D. Feldman, Timothy Baradet, Albert Lo, Jing Sun, Kheng Newick, Edmund Moon, Zack Gershenson, Vijay Bhoj, Ching-Yi Tsai, Liang-Chuan Wang, Enxiu Wang
CD19-specific KIR-CAR/Dap12 shows antigen-specific cytotoxicity in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1b2dcb3c6784c42ee74838e97e8b53
https://doi.org/10.1158/2326-6066.22538609
https://doi.org/10.1158/2326-6066.22538609
Autor:
Michael C. Milone, Steven Albelda, Ellen Puré, David Barrett, Michael D. Feldman, Timothy Baradet, Albert Lo, Jing Sun, Kheng Newick, Edmund Moon, Zack Gershenson, Vijay Bhoj, Ching-Yi Tsai, Liang-Chuan Wang, Enxiu Wang
Chimeric antigen receptors (CAR) bearing an antigen-binding domain linked in cis to the cytoplasmic domains of CD3ζ and costimulatory receptors have provided a potent method for engineering T-cell cytotoxicity toward B-cell leukemia and lymphoma. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8067d02561e9fbfd36597e9c839d054d
https://doi.org/10.1158/2326-6066.c.6548822.v1
https://doi.org/10.1158/2326-6066.c.6548822.v1
Autor:
Michael C. Milone, Steven Albelda, Ellen Puré, David Barrett, Michael D. Feldman, Timothy Baradet, Albert Lo, Jing Sun, Kheng Newick, Edmund Moon, Zack Gershenson, Vijay Bhoj, Ching-Yi Tsai, Liang-Chuan Wang, Enxiu Wang
SS1-KIRS2 does not affect endogenous TCR expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0531299f4bc9087590547c20d59826f4
https://doi.org/10.1158/2326-6066.22538618
https://doi.org/10.1158/2326-6066.22538618
Autor:
Michael C. Milone, Steven Albelda, Ellen Puré, David Barrett, Michael D. Feldman, Timothy Baradet, Albert Lo, Jing Sun, Kheng Newick, Edmund Moon, Zack Gershenson, Vijay Bhoj, Ching-Yi Tsai, Liang-Chuan Wang, Enxiu Wang
Figure legends for supplemental data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d46e60c2f9840877f47115dc7ae9ec
https://doi.org/10.1158/2326-6066.22538600.v1
https://doi.org/10.1158/2326-6066.22538600.v1
Autor:
Michael C. Milone, Steven Albelda, Ellen Puré, David Barrett, Michael D. Feldman, Timothy Baradet, Albert Lo, Jing Sun, Kheng Newick, Edmund Moon, Zack Gershenson, Vijay Bhoj, Ching-Yi Tsai, Liang-Chuan Wang, Enxiu Wang
SS1-KIRS2/DAP12 T cells mediate robust anti-tumor activity in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b504d29204d6c2f280c7fff0f89e34
https://doi.org/10.1158/2326-6066.22538612.v1
https://doi.org/10.1158/2326-6066.22538612.v1
Autor:
Michael C. Milone, Steven Albelda, Ellen Puré, David Barrett, Michael D. Feldman, Timothy Baradet, Albert Lo, Jing Sun, Kheng Newick, Edmund Moon, Zack Gershenson, Vijay Bhoj, Ching-Yi Tsai, Liang-Chuan Wang, Enxiu Wang
Cytotoxicity induced by SS1-KIRS2, but not receptor expression at the cell surface, depends upon DAP12 co-expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a25e829ead3189da1f1d95012eedd97
https://doi.org/10.1158/2326-6066.22538621
https://doi.org/10.1158/2326-6066.22538621