Zobrazeno 1 - 10 of 1 099 pro vyhledávání: '"Steven AN Goldstein"'
1
Akademický článek
SUMOylation of NaV1.2 channels regulates the velocity of backpropagating action potentials in cortical pyramidal neurons
Autor: Oron Kotler, Yana Khrapunsky, Arik Shvartsman, Hui Dai, Leigh D Plant, Steven AN Goldstein, Ilya Fleidervish
Publikováno v: eLife, Vol 12 (2023)
Voltage-gated sodium channels located in axon initial segments (AIS) trigger action potentials (AP) and play pivotal roles in the excitability of cortical pyramidal neurons. The differential electrophysiological properties and distributions of NaV1.2
Externí odkaz: https://doaj.org/article/77f8c9ae611943e0a75a929dc508cb04
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2
Akademický článek
The molecular basis of pH sensing by the human fungal pathogen Candida albicans TOK potassium channel
Autor: Rían W. Manville, Claire L. Illeck, Anthony Lewis, Zoe A. McCrossan, Steven A.N. Goldstein, Geoffrey W. Abbott
Publikováno v: iScience, Vol 27, Iss 12, Pp 111451- (2024)
Summary: Two-pore domain, outwardly rectifying potassium (TOK) channels are exclusively expressed in fungi. Human fungal pathogen TOK channels are potential antifungal targets, but TOK channel modulation in general is poorly understood. Here, we disc
Externí odkaz: https://doaj.org/article/6ba5f0fc4db445e7acb197f3702880bb
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3
Akademický článek
Helium in diamonds unravels over a billion years of craton metasomatism
Autor: Yaakov Weiss, Yael Kiro, Cornelia Class, Gisela Winckler, Jeff W. Harris, Steven L. Goldstein
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Diamonds encapsulate the deep Earth fluids that form them, providing windows to deep mantle processes. This study constrains their ages, based on uranium-thorium-to-helium radioactive decay in the fluids and helium diffusivity in diamond, and relates
Externí odkaz: https://doaj.org/article/75ec0c4cafd64ae7be4d3e8d2901062a
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4
Akademický článek
Ancient proteins provide evidence of dairy consumption in eastern Africa
Autor: Madeleine Bleasdale, Kristine K. Richter, Anneke Janzen, Samantha Brown, Ashley Scott, Jana Zech, Shevan Wilkin, Ke Wang, Stephan Schiffels, Jocelyne Desideri, Marie Besse, Jacques Reinold, Mohamed Saad, Hiba Babiker, Robert C. Power, Emmanuel Ndiema, Christine Ogola, Fredrick K. Manthi, Muhammad Zahir, Michael Petraglia, Christian Trachsel, Paolo Nanni, Jonas Grossmann, Jessica Hendy, Alison Crowther, Patrick Roberts, Steven T. Goldstein, Nicole Boivin
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Consuming the milk of other species is a unique adaptation of Homo sapiens. Here, the authors carry out proteomic analysis of dental calculus of 41 ancient individuals from Sudan and Kenya, indicating milk consumption occurred as soon as herding spre
Externí odkaz: https://doaj.org/article/ef43012736674fc98fcd35c24eab5c39
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6
Akademický článek
Distinguishing African bovids using Zooarchaeology by Mass Spectrometry (ZooMS): New peptide markers and insights into Iron Age economies in Zambia.
Autor: Anneke Janzen, Kristine Korzow Richter, Ogeto Mwebi, Samantha Brown, Veronicah Onduso, Filia Gatwiri, Emmanuel Ndiema, Maggie Katongo, Steven T Goldstein, Katerina Douka, Nicole Boivin
Publikováno v: PLoS ONE, Vol 16, Iss 5, p e0251061 (2021)
Assessing past foodways, subsistence strategies, and environments depends on the accurate identification of animals in the archaeological record. The high rates of fragmentation and often poor preservation of animal bones at many archaeological sites
Externí odkaz: https://doaj.org/article/a00821a176f1411a986e96570705a326
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7
Akademický článek
Sequential extraction procedure to obtain the composition of terrigenous detritus in marine sediments
Autor: Margit H. Simon, Daniel P. Babin, Steven L. Goldstein, Merry Yue Cai, Tanzhuo Liu, Xibin Han, Anne A. Haws, Matthew Johns, Caroline Lear, Sidney R. Hemming
Publikováno v: MethodsX, Vol 7, Iss , Pp 100888- (2020)
The geochemical and isotopic composition of terrigenous clays from marine sediments can provide important information on the sources and pathways of sediments. In order to extract the detrital signal from bulk marine sediments, standard sediment leac
Externí odkaz: https://doaj.org/article/ac4ab39f50274b9e9bdc1a870783f0f6
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