Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Steven A. Middleton"'
Autor:
Bernhard Reis, Lori Jukofsky, Gong Chen, Giovanni Martinelli, Hua Zhong, W. Venus So, Michael J. Dickinson, Mark Drummond, Sarit Assouline, Maneja Hashemyan, Michel Theron, Steven Blotner, Je-Hwan Lee, Margaret Kasner, Sung-Soo Yoon, Ruediger Rueger, Karen Seiter, Steven A. Middleton, Kevin R. Kelly, Norbert Vey, Karen Yee, Gwen Nichols, Lin-Chi Chen, William E. Pierceall
Publikováno v:
Haematologica, Vol 101, Iss 5 (2016)
Externí odkaz:
https://doaj.org/article/3b298cf633754071a74408ada3da815c
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Bilaterally projecting CA3 inputs may be crucial for integrating the left and right CA1 during memory but this has not been directly examined. Here, the authors show that projections from bilateral CA3 play a key role in the cross-hemispheric coordin
Externí odkaz:
https://doaj.org/article/94955a31eba443dc84f83d6d0fdafa3a
Autor:
Jimena Perez-Sanchez, Steven J. Middleton, Luke A. Pattison, Helen Hilton, Mosab Ali Awadelkareem, Sana R. Zuberi, Maria B. Renke, Huimin Hu, Xun Yang, Alex J. Clark, Ewan St, John Smith, David L. Bennett
Hyperexcitability in sensory neurons is known to underlie many of the maladaptive changes associated with persistent pain. Chemogenetics has shown promise as a means to suppress such excitability, yet chemogenetic approaches suitable for human applic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9a201550328dc67e8ff53193ad20a64
https://doi.org/10.1101/2023.03.21.533690
https://doi.org/10.1101/2023.03.21.533690
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications
Nature Communications
In the hippocampal circuit CA3 input plays a critical role in the organization of CA1 population activity, both during learning and sleep. While integrated spatial representations have been observed across the two hemispheres of CA1, these regions la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abaaeeacf7f5536e575558697837e89a
https://doaj.org/article/94955a31eba443dc84f83d6d0fdafa3a
https://doaj.org/article/94955a31eba443dc84f83d6d0fdafa3a
Publikováno v:
Journal of Anatomy. 241:1186-1210
Primary sensory neurons are a heterogeneous population of cells able to respond to both innocuous and noxious stimuli. Like most neurons they are highly compartmentalised, allowing them to detect, convey and transfer sensory information. These compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f2aa5efef45f2d2371aa537c31fa76
https://doi.org/10.1111/joa.13544
https://doi.org/10.1111/joa.13544
Autor:
Teodora Trendafilova, Kaustubh Adhikari, Annina B. Schmid, Ryan Patel, Erika Polgár, Kim I. Chisholm, Steven J. Middleton, Kieran Boyle, Allen C. Dickie, Evangelia Semizoglou, Jimena Perez-Sanchez, Andrew M. Bell, Luis Miguel Ramirez-Aristeguieta, Samar Khoury, Aleksandar Ivanov, Hendrik Wildner, Eleanor Ferris, Juan-Camilo Chacón-Duque, Sophie Sokolow, Mohamed A. Saad Boghdady, André Herchuelz, Pierre Faux, Giovanni Poletti, Carla Gallo, Francisco Rothhammer, Gabriel Bedoya, Hanns Ulrich Zeilhofer, Luda Diatchenko, Stephen B. McMahon, Andrew J. Todd, Anthony H. Dickenson, Andres Ruiz-Linares, David L. Bennett
Publikováno v:
Neuron, 110 (16)
Repeated application of noxious stimuli leads to a progressively increased pain perception; this temporal summation is enhanced in and predictive of clinical pain disorders. Its electrophysiological correlate is “wind-up,” in which dorsal horn sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df091f7ef0a309761bab165ab5c500b
https://hdl.handle.net/20.500.11850/566573
https://hdl.handle.net/20.500.11850/566573
Autor:
Chinnakkaruppan Adaikkan, Jun Wang, Karim Abdelaal, Steven J. Middleton, P. Lorenzo Bozzelli, Ian R. Wickersham, Thomas J. McHugh, Li-Huei Tsai
Publikováno v:
Neuron. 110:3091-3105.e9
A major pathological hallmark of neurodegenerative diseases, including Alzheimer's, is a significant reduction in the white matter connecting the two cerebral hemispheres, as well as in the correlated activity between anatomically corresponding bilat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2995f059f58697d366f9eb8585cf252
https://doi.org/10.1016/j.neuron.2022.07.023
https://doi.org/10.1016/j.neuron.2022.07.023
Autor:
Steven J Middleton, Irene Perini, Andreas C Themistocleous, Greg A Weir, Kirsty McCann, Allison M Barry, Andrew Marshall, Michael Lee, Leah M Mayo, Manon Bohic, Georgios Baskozos, India Morrison, Line S Löken, Sarah McIntyre, Saad S Nagi, Roland Staud, Isac Sehlstedt, Richard D Johnson, Johan Wessberg, John N Wood, Christopher G Woods, Aziz Moqrich, Håkan Olausson, David L Bennett
Publikováno v:
Brain-A Journal of Neurology
Brain-A Journal of Neurology, 2022, 145 (10), pp.3637-3653. ⟨10.1093/brain/awab482⟩
Brain-A Journal of Neurology, 2022, 145 (10), pp.3637-3653. ⟨10.1093/brain/awab482⟩
Patients with bi-allelic loss of function mutations in the voltage-gated sodium channel Nav1.7 present with congenital insensitivity to pain (CIP), whilst low threshold mechanosensation is reportedly normal. Using psychophysics (n = 6 CIP participant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f537374d00c370e3f7f00e1f65e4c22e
https://pubmed.ncbi.nlm.nih.gov/34957475
https://pubmed.ncbi.nlm.nih.gov/34957475
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85269 (2014)
A fundamental issue in neuroscience is how to identify the multiple biophysical mechanisms through which neurons generate observed patterns of spiking activity. In previous work, we proposed a method for linking observed patterns of spiking activity
Externí odkaz:
https://doaj.org/article/47f0f8a22a4f4de99278e477b3b2e88f
Autor:
Chinnakkaruppan Adaikkan, Thomas J. McHugh, Li-Huei Tsai, Ian R. Wickersham, Jun Wang, Karim Abdelaal, Steven J. Middleton
Publikováno v:
SSRN Electronic Journal.
SUMMARYA clinical hallmark of Alzheimer’s disease is significant reductions in the white matter connecting the two cerebral hemispheres, as well as in the correlated activity between anatomically corresponding bilateral brain areas. However, the un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6da260fe4112c5a41eb969e7c52c3887
https://doi.org/10.2139/ssrn.3887797
https://doi.org/10.2139/ssrn.3887797