Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Steven A. Mazzuca"'
Publikováno v:
Arthritis Care & Research. 63:1528-1534
Objective To explore whether the risk of incident tibiofemoral (TF) osteoarthritis (OA) in the radiographically normal contralateral knee of overweight/obese women with unilateral knee OA is mediated by malalignment and/or preceded by increased turno
Publikováno v:
Rheumatology. 45:1389-1394
Objective. To determine the extent to which treatment of patients with symptomatic knee osteoarthritis (OA) with non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen (ACET) reduces total effusion volume and synovial tissue volume, as quan
Autor:
Steven A. Mazzuca, Kenneth D. Brandt
Publikováno v:
Rheumatic Disease Clinics of North America. 32:217-234
Little effort has gone into the development of more effective analgesics for osteoarthritic pain. Efforts to improve symptomatic therapy for osteoarthritis have been deflected or diluted by a decision to pursue the development of disease-modifying OA
Publikováno v:
Annals of the Rheumatic Diseases. 65:64-68
Objective: To compare quantitative estimates of change in joint space width (JSW) with semiquantitative ratings of the progression of joint space narrowing (JSN) with respect to sensitivity to change over time. Methods: 431 obese women 45 to 64 years
Autor:
Steven A. Mazzuca, Kathleen A. Lane, Leena Sharma, John D. Bradley, Steven T. Hugenberg, Louis W. Heck, Kenneth A. Buckwalter, Chester V. Oddis, Thomas J. Schnitzer, Kenneth D. Brandt, Larry W. Moreland, Frederick Wolfe, David E. Yocum, Barry P. Katz, Susan Manzi
Publikováno v:
Arthritis & Rheumatism. 52:2015-2025
Objective To confirm preclinical data suggesting that doxycycline can slow the progression of osteoarthritis (OA). The primary outcome measure was joint space narrowing (JSN) in the medial tibiofemoral compartment. Methods In this placebo-controlled
Autor:
Staffan Larsson, Kathleen A. Lane, Steven A. Mazzuca, Kenneth D. Brandt, André Struglics, Barry P. Katz, L. Stefan Lohmander
Publikováno v:
Arthritis & Rheumatism. 52:3160-3167
Objective To determine whether baseline or serial plasma concentrations of stromelysin (matrix metalloproteinase 3 [MMP-3]) protein might distinguish subjects with progressive radiographic knee osteoarthritis (OA) from those with stable disease. Meth
Autor:
Steven A. Mazzuca, Chester V. Oddis, Steven T. Hugenberg, John D. Bradley, Kathleen A. Lane, Frederick Wolfe, Kenneth D. Brandt, Barry P. Katz, Susan Manzi, Larry W. Moreland, David E. Yocum, Leena Sharma, Thomas J. Schnitzer, Louis W. Heck
Publikováno v:
Arthritis Care & Research. 51:933-940
Objective To describe the methods by which remarkable levels of subject retention and adherence were achieved in a 30-month multicenter randomized placebo-controlled trial (RCT) of a disease-modifying osteoarthritis drug (DMOAD). Methods Subjects wer
Publikováno v:
Journal of Thermophysics and Heat Transfer. 18:193-202
The heat flow across a high-powered silicon-die and water-cooled heat-sink assembly is a very important thermal challenge in many microelectronic applications. A single silicon thermal-die/water-cooled experimental facility was fabricated, and a succ
Publikováno v:
Arthritis & Rheumatism. 50:2508-2515
Objective Computerized measurement of changes in joint space width (JSW) on serial radiographs of the knee in the semiflexed, anteroposterior (SF-AP) view has been used recently as a primary outcome measure in clinical trials of disease-modifying ost
Autor:
Steven A. Mazzuca, Kenneth D. Brandt
Publikováno v:
Rheumatic Disease Clinics of North America. 29:819-830
Recent research on the radiographic imaging of knee OA has helped clarify the features of imaging protocols that contribute to accurate representation of disease severity--specifically, the thickness of articular cartilage--and to sensitive detection