Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Steven A. Kell"'
Autor:
Riley Perszyk, Brooke M Katzman, Hirofumi Kusumoto, Steven A Kell, Matthew P Epplin, Yesim A Tahirovic, Rhonda L Moore, David Menaldino, Pieter Burger, Dennis C Liotta, Stephen F Traynelis
Publikováno v:
eLife, Vol 7 (2018)
N-methyl-d-aspartate receptors (NMDARs) are an important receptor in the brain and have been implicated in multiple neurological disorders. Many non-selective NMDAR-targeting drugs are poorly tolerated, leading to efforts to target NMDAR subtypes to
Externí odkaz:
https://doaj.org/article/ebbc00f7f3b642f9a1fc75a7e8319d7c
Autor:
Zongjian Zhu, George W. Koszalka, Dennis C. Liotta, Rhonda L. Moore, Steven A. Kell, David S. Menaldino, Stephen F. Traynelis, Scott J. Myers, Samantha L. Summer
Publikováno v:
ACS Medicinal Chemistry Letters. 10:248-254
[Image: see text] The N-methyl-d-aspartate receptor plays a critical role in central nervous system processes. Its diverse properties, as well as hypothesized role in neurological disease, render NMDA receptors a target of interest for the developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c559418bdd69a66568a49ad1830a0f2
https://doi.org/10.1021/acsmedchemlett.8b00395
https://doi.org/10.1021/acsmedchemlett.8b00395
Autor:
Miranda J. McDaniel, Stephen F. Traynelis, Dennis C. Liotta, Pieter B. Burger, Kevin K. Ogden, Steven A. Kell
Publikováno v:
The Journal of General Physiology
Mutations in the pre-M1 helix of NMDA receptor subunits are associated with neurological disease. McDaniel et al. reveal that the helix influences channel gating, potentially through interactions with a network of aromatic amino acids within the subu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d477df81c021f0ef688d7891597ce72d
https://doi.org/10.1085/jgp.201912362
https://doi.org/10.1085/jgp.201912362
Autor:
Christopher J. Butch, Pieter B. Burger, Alasdair J. Gibb, Stephen F. Traynelis, Kevin K. Ogden, Dennis C. Liotta, Miranda J. McDaniel, Steven A. Kell, Katie M. Vance
Publikováno v:
The Journal of Physiology. 596:4057-4089
NMDA receptors (NMDARs) are tetrameric complexes comprising two glycine‐binding GluN1 and two glutamate‐binding GluN2 subunits. Four GluN2 subunits encoded by different genes can produce up to 10 different di‐ and triheteromeric receptors. In a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8f3674fbb36752960d059f87361ef27
https://doi.org/10.1113/jp276093
https://doi.org/10.1113/jp276093
Autor:
Yoon Hyeun Oum, Younghyoun Yoon, Zhongxing Liang, Steven A. Kell, Pieter B. Burger, Hyunsuk Shim
Publikováno v:
Eur J Med Chem
The C-X-C chemokine receptor type 4 (CXCR4) is a potential therapeutic target for HIV infection, metastatic cancer, and inflammatory autoimmune diseases. In this study, we screened the ZINC chemical database for novel CXCR4 modulators through a serie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8174aadfadcaa0bd35b5c1777e71f5fd
https://doi.org/10.1016/j.ejmech.2020.112479
https://doi.org/10.1016/j.ejmech.2020.112479
Publikováno v:
Structure. 28:196-205.e3
Understanding how changes in amino acid sequence alter protein dynamics and allosteric signaling would illuminate strategies for protein design. To gain insight into this process, we have combined molecular dynamics simulations with ancestral sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695ecc068fd873e7b8d129abeb27148c
https://doi.org/10.1016/j.str.2019.11.012
https://doi.org/10.1016/j.str.2019.11.012
Autor:
Matthew P. Epplin, Brooke M Katzman, Yesim Altas Tahirovic, David S. Menaldino, Riley E. Perszyk, Stephen F. Traynelis, Hirofumi Kusumoto, Pieter B. Burger, Steven A. Kell, Rhonda L. Moore, Dennis C. Liotta
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
N-methyl-d-aspartate receptors (NMDARs) are an important receptor in the brain and have been implicated in multiple neurological disorders. Many non-selective NMDAR-targeting drugs are poorly tolerated, leading to efforts to target NMDAR subtypes to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b919a57d8e8d534ef377876d216651b
https://doi.org/10.7554/elife.34711
https://doi.org/10.7554/elife.34711
Autor:
Matthew P. Epplin, Yesim Altas Tahirovic, Brooke M Katzman, David S. Menaldino, Stephen F. Traynelis, Riley E. Perszyk, Steven A. Kell, Hirofumi Kusumoto, Pieter B. Burger, Dennis C. Liotta, Rhonda L. Moore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b8dfb68c0d9eebde7c1e00310b86c0b
https://doi.org/10.7554/elife.34711.058
https://doi.org/10.7554/elife.34711.058
Autor:
Hirofumi Kusumoto, Eric J. Miller, Steven A. Kell, David S. Menaldino, Bryan Cox, Stephen F. Traynelis, Pieter B. Burger, Dennis C. Liotta, Gil Shaulsky, Katie L. Strong, Matthew P. Epplin, Subhrajit Bhattacharya, Thomas M. Kaiser
Publikováno v:
Molecular pharmacology. 93(2)
N-methyl-d-aspartate (NMDA) receptors are ligand-gated, cation-selective channels that mediate a slow component of excitatory synaptic transmission. Subunit-selective positive allosteric modulators of NMDA receptor function have therapeutically relev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45cc74c14f522a724bcb324650044b9a
https://pubmed.ncbi.nlm.nih.gov/29242355
https://pubmed.ncbi.nlm.nih.gov/29242355
Autor:
Jon Leachtenauer, Beverely Turner, Chris Newcomer, Steven W. Kell, Courtney H. Lyder, Majd Alwan
Publikováno v:
EMBC
This paper describes a non-contact imaging-based method to detect stage I pressure ulcers over a wide range of melanin levels. Two approaches were explored: the first used broad and narrow band visible spectrum imaging, and the second used near infra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb91b8499a4923f71ddc605fb996487
https://pubmed.ncbi.nlm.nih.gov/17946762
https://pubmed.ncbi.nlm.nih.gov/17946762