Zobrazeno 1 - 10
of 573
pro vyhledávání: '"Steven A. Gross"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Cells run on initiation of protein-protein interactions, which are dynamically tuned spatially and temporally to modulate cellular events. This tuning can be physical, such as attaching the protein to a cargo or protein complex, thereby alte
Externí odkaz:
https://doaj.org/article/addb22709a054f5db7d6d61b8f6e3a4d
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 5, p e1012158 (2024)
The self-organization of cells relies on the profound complexity of protein-protein interactions. Challenges in directly observing these events have hindered progress toward understanding their diverse behaviors. One notable example is the interactio
Externí odkaz:
https://doaj.org/article/e910b4dc61b743fdb8aad8b0ddc245a0
Autor:
Adenrele Oludiran, Areej Malik, Andriana C Zourou, Yonghan Wu, Steven P Gross, Albert Siryapon, Asia Poudel, Kwincy Alleyne, Savion Adams, David S Courson, Myriam L Cotten, Erin B Purcell
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0295627 (2024)
The spore-forming intestinal pathogen Clostridioides difficile causes multidrug resistant infection with a high rate of recurrence after treatment. Piscidins 1 (p1) and 3 (p3), cationic host defense peptides with micromolar cytotoxicity against C. di
Externí odkaz:
https://doaj.org/article/e1ec5dce5cf944358f821c1a4eceafce
Autor:
Nneka Southwell, Guido Primiano, Viraj Nadkarni, Nabeel Attarwala, Emelie Beattie, Dawson Miller, Sumaitaah Alam, Irene Liparulo, Yevgeniya I Shurubor, Maria Lucia Valentino, Valerio Carelli, Serenella Servidei, Steven S Gross, Giovanni Manfredi, Qiuying Chen, Marilena D'Aurelio
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 7, Pp 1-26 (2023)
Abstract Mitochondrial diseases are a heterogeneous group of monogenic disorders that result from impaired oxidative phosphorylation (OXPHOS). As neuromuscular tissues are highly energy‐dependent, mitochondrial diseases often affect skeletal muscle
Externí odkaz:
https://doaj.org/article/3ac8c9834e7f48439c744d6d9391fd6b
Autor:
Johannes C. van der Mijn, Kristian B. Laursen, Leiping Fu, Francesca Khani, Lukas E. Dow, Dawid G. Nowak, Qiuying Chen, Steven S. Gross, David M. Nanus, Lorraine J. Gudas
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Genetically engineered mouse models (GEMMs) are important immunocompetent models for research into the roles of individual genes in cancer and the development of novel therapies. Here we use inducible CRISPR-Cas9 systems to develop two GEMMs
Externí odkaz:
https://doaj.org/article/663f362a226d470abe3578034e1b34b8
Autor:
Xuanye Cao, Jianfeng Xu, Ying L. Lin, Robert M. Cabrera, Qiuying Chen, Chaofan Zhang, John W. Steele, Xiao Han, Steven S. Gross, Bogdan J. Wlodarczyk, James R. Lupski, Wei Li, Hongyan Wang, Richard H. Finnell, Yunping Lei
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-5 (2023)
Externí odkaz:
https://doaj.org/article/cac18d4dab7a40cb90efaf4b8f0c2cda
Autor:
Jacqueline G. Parchem, Huihui Fan, Lovepreet K. Mann, Qiuying Chen, Jong H. Won, Steven S. Gross, Zhongming Zhao, Heinrich Taegtmeyer, Ramesha Papanna
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107424- (2023)
Summary: Monochorionic-diamniotic twin pregnancies are susceptible to unique complications arising from a single placenta shared by two fetuses. Twin-twin transfusion syndrome (TTTS) is a constellation of disturbances caused by unequal blood flow wit
Externí odkaz:
https://doaj.org/article/2599e509bc3844599192c8c6966c430f
Autor:
Tory Doolin, Henry M. Amir, Leora Duong, Rachel Rosenzweig, Lauren A. Urban, Marta Bosch, Albert Pol, Steven P. Gross, Albert Siryaporn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Histones have a role in antimicrobial defense. Here, the authors show that the histone H2A and the antimicrobial peptide LL-37 exert synergistic effects by enhancing bacterial membrane pores and enabling H2A entry into the bacterial cytoplasm, where
Externí odkaz:
https://doaj.org/article/b32d941bdfe447b68dbe6452c3da533c
Autor:
Johannes C. van der Mijn, Leiping Fu, Francesca Khani, Tuo Zhang, Ana M. Molina, Christopher E. Barbieri, Qiuying Chen, Steven S. Gross, Lorraine J. Gudas, David M. Nanus
Publikováno v:
Translational Oncology, Vol 13, Iss 2, Pp 177-185 (2020)
The accumulation of lipids is a hallmark of human clear cell renal cell carcinoma (ccRCC). Advanced ccRCC tumors frequently show increased lipid biosynthesis, but the regulation of lipid metabolism in early stage ccRCC tumors has not been studied. He
Externí odkaz:
https://doaj.org/article/26b5223318384c0ab3149631b4ea0af2
Autor:
John W. Steele, Ying Linda Lin, Nellie Chen, Bogdan J. Wlodarczyk, Qiuying Chen, Nabeel Attarwala, Madhu Venkatesalu, Robert M. Cabrera, Steven S. Gross, Richard H. Finnell
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Valproic acid (VPA, valproate, Depakote) is a commonly used anti-seizure medication (ASM) in the treatment of epilepsy and a variety of other neurological disorders. While VPA and other ASMs are efficacious for management of seizures, they also incre
Externí odkaz:
https://doaj.org/article/6faac93a50304eb38ab9cdafe391c47f