Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Steven A. Farber"'
Autor:
James H. Thierer, Ombretta Foresti, Pradeep Kumar Yadav, Meredith H. Wilson, Tabea O. C. Moll, Meng-Chieh Shen, Elisabeth M. Busch-Nentwich, Margaret Morash, Karen L. Mohlke, John F. Rawls, Vivek Malhotra, M. Mahmood Hussain, Steven A. Farber
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Vertebrates transport hydrophobic triglycerides through the circulatory system by packaging them within amphipathic particles called Triglyceride-Rich Lipoproteins. Yet, it remains largely unknown how triglycerides are loaded onto these part
Externí odkaz:
https://doaj.org/article/0c842b9c7eca4be6a40b1c67e56efa1a
Autor:
James H. Thierer, Ombretta Foresti, Pradeep Kumar Yadav, Meredith H. Wilson, Tabea O. C. Moll, Meng-Chieh Shen, Elisabeth M. Busch-Nentwich, Margaret Morash, Karen L. Mohlke, John F. Rawls, Vivek Malhotra, M. Mahmood Hussain, Steven A. Farber
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/1aabdb2bf28d41d2a79b6d4579ae6e87
Autor:
Jillian L. Ellis, Kimberley J. Evason, Changwen Zhang, Makenzie N. Fourman, Jiandong Liu, Nikolay Ninov, Marion Delous, Benoit Vanhollebeke, Ian Fiddes, Jessica P. Otis, Yariv Houvras, Steven A. Farber, Xiaolei Xu, Xueying Lin, Didier Y. R. Stainier, Chunyue Yin
Publikováno v:
Hepatology Communications, Vol 6, Iss 11, Pp 3083-3097 (2022)
Abstract Hepatic cysts are fluid‐filled lesions in the liver that are estimated to occur in 5% of the population. They may cause hepatomegaly and abdominal pain. Progression to secondary fibrosis, cirrhosis, or cholangiocarcinoma can lead to morbid
Externí odkaz:
https://doaj.org/article/56e077b691b242e1a3b5f2383c323660
Autor:
Jayanth Jawahar, Alexander W. McCumber, Colin R. Lickwar, Caroline R. Amoroso, Sol Gomez de la Torre Canny, Sandi Wong, Margaret Morash, James H. Thierer, Steven A. Farber, Brendan J. M. Bohannan, Karen Guillemin, John F. Rawls
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-19 (2022)
Abstract Background The ability of animals and their microbiomes to adapt to starvation and then restore homeostasis after refeeding is fundamental to their continued survival and symbiosis. The intestine is the primary site of nutrient absorption an
Externí odkaz:
https://doaj.org/article/08d486c495ba4c1a9aabba407037981a
Autor:
Meghan T. Walsh, Oni M. Celestin, James H. Thierer, Sujith Rajan, Steven A. Farber, M. Mahmood Hussain
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 3, Pp 316-327 (2020)
apoB exists as apoB100 and apoB48, which are mainly found in hepatic VLDLs and intestinal chylomicrons, respectively. Elevated plasma levels of apoB-containing lipoproteins (Blps) contribute to coronary artery disease, diabetes, and other cardiometab
Externí odkaz:
https://doaj.org/article/b79a7d6c3d2d4495bfd571be0c669769
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Atherosclerosis results from the accumulation of lipoproteins in the vascular wall. Here, Thierer et al. report the design of a chemiluminescent reporter for atherogenic lipoproteins using fusion of apolipoprotein-B to a luciferase enzyme, and find i
Externí odkaz:
https://doaj.org/article/d6fe8db78b3a4164a8ddbb6eb1152a2f
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 5, Pp 1008-1020 (2017)
Fluorescent lipids are important tools for live imaging in cell culture and animal models, yet their metabolism has not been well-characterized. Here we describe a novel combined HPLC and LC-MS/MS method developed to characterize both total lipid pro
Externí odkaz:
https://doaj.org/article/0f79d2a2742c495aaad1aef81bdd3348
Intestinal epithelial cell caveolin 1 regulates fatty acid and lipoprotein cholesterol plasma levels
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 3, Pp 283-295 (2017)
Caveolae and their structural protein caveolin 1 (CAV1) have roles in cellular lipid processing and systemic lipid metabolism. Global deletion of CAV1 in mice results in insulin resistance and increases in atherogenic plasma lipids and cholesterol, b
Externí odkaz:
https://doaj.org/article/ff86e8b3ccf140b795d907a5f053f5c2
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/8279b9ba6b3841dda017d6bfe4da43d8
Autor:
Vanessa H. Quinlivan, Steven A. Farber
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2017)
The developing zebrafish is a well-established model system for studies of energy metabolism, and is amenable to genetic, physiological, and biochemical approaches. For the first 5 days of life, nutrients are absorbed from its endogenous maternally d
Externí odkaz:
https://doaj.org/article/6d8a97f3a55b406e84223de86814159c