Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Steven A. Everett"'
Autor:
S. Moncada, E. A. Higgs, K. Anne Smith, Steven A. Everett, G. Bagetta, G. Nisticò, Peter Wardman
Publikováno v:
Nitric Oxide and the Cell: Proliferation, Differentiation, and Death
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d67bff95e64c6fd41696608fe5c789f
https://doi.org/10.1515/9781400887538-011
https://doi.org/10.1515/9781400887538-011
One-electron oxidation of (6R)-5,6,7,8-tetrahydrobiopterin (H(4)B) by the azide radical generates the radical cation (H(4)B(*)(+)) which rapidly deprotonates at physiological pH to give the neutral trihydrobiopterin radical (H(3)B(*)); pK(a) (H(4)B(*
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f336a897fab025fd4a9fc8b39c16561
https://ora.ox.ac.uk/objects/uuid:3884d5a8-90a3-4794-a9bc-10717f1eae4a
https://ora.ox.ac.uk/objects/uuid:3884d5a8-90a3-4794-a9bc-10717f1eae4a
Autor:
Kantilal B. Patel, Sarah C. Hill, Peter Thomson, Matthew A. Naylor, Steven A. Everett, Michael R.L. Stratford, Peter Wardman, Peter D Davis, Gemma Lewis
Nitrothienylprop-2-yl ether formation on the 3′-phenolic position of combretastatin A-4 (1) abolishes the cytotoxicity and tubulin polymerization-inhibitory effects of the drug. 5-Nitrothiophene derivatives of 1 were synthesized following model kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4370e859c161e4139e2273c8c46e05b
https://ora.ox.ac.uk/objects/uuid:1b77d0c1-e8cd-476c-9d86-87ff15105ec8
https://ora.ox.ac.uk/objects/uuid:1b77d0c1-e8cd-476c-9d86-87ff15105ec8
Autor:
Elizabeth Swann, Christopher J. Moody, Steven A. Everett, Kantilal B. Patel, Peter Wardman, Matthew A. Naylor, Michael R.L. Stratford, Borivoj Vojnovic
Publikováno v:
Scopus-Elsevier
A series of indolequinones bearing substituted nitrophenols on the (indol-3-yl)methyl position was synthesised. The nitrophenol leaving groups were appropriately substituted to give a wide range (4 units) in phenolic pKa value. The rate of reductive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add00be5ccb23f6185cb86ba2761148d
https://ora.ox.ac.uk/objects/uuid:568e56fa-9e5c-4374-967d-6ea510de29b9
https://ora.ox.ac.uk/objects/uuid:568e56fa-9e5c-4374-967d-6ea510de29b9
Autor:
Julian D. Gilbey, Steven A. Everett, Gary K. Atkin, Paul R. Barber, Frances M. Daley, Borivoj Vojnovic, George S. Wilson
Publikováno v:
Journal of Physics D: Applied Physics. 36:1729-1738
The application of a cost-effective spectral imager to spatially segmenting absorptive and fluorescent chemical probes on the basis of their spectral characteristics has been demonstrated. The imager comprises a computer-controlled spectrally selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c8c3fdb1c2cd9cac09d7892c7fda15
https://doi.org/10.1088/0022-3727/36/14/312
https://doi.org/10.1088/0022-3727/36/14/312
Autor:
Peter Wardman, Mark J. Burkitt, Borivoj Vojnovic, Steven A. Everett, Kantilal B. Patel, Andrew Lawrence, Clare M. Jones
Publikováno v:
Journal of Fluorescence. 12:65-68
Lucigenin (LC 2+ , bis-N-methylacridinium) and 28,78 -dichlorofluorescin (DCFH2) are widely used as chemiluminescent or fluorescent probes for cellular oxidative stress, to reflect levels of superoxide (O2 ?2 ) and hydrogen peroxide, respectively. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::763381a3e8192880912c0f00f3b1f5f7
https://doi.org/10.1023/a:1015363220266
https://doi.org/10.1023/a:1015363220266
Autor:
S. Ulhaq, Ian J. Stratford, Steven A. Everett, Michael R. L. Stratford, Peter Wardman, Matthew A. Naylor, John Nolan, S. G. Moore, M Jaffar, K. B. Patel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:113-118
A series of regioisomeric derivatives of a 1-methylindole-4,7-dione were synthesised, substituted with a 2-acetoxybenzoate leaving group linked through the (indol-2-yl)methyl or (indol-3-yl)methyl (or propenyl) positions. Reductive elimination of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e26691adbf29cb6acaf31cdfe1e7ac
https://doi.org/10.1016/s0960-894x(98)00695-7
https://doi.org/10.1016/s0960-894x(98)00695-7
Autor:
K.Anne Smith, Madeleine F. Dennis, Peter Wardman, Steven A. Everett, Michael R.L. Stratford, K. B. Patel
Publikováno v:
Free Radical Biology and Medicine. 24:1-10
The oxidative denitrification of the antitumour agent hydroxyguanidine (HOG) has been investigated by radiolysis methods and EPR spectroscopy. The azide radical (N3), a model one-electron oxidant, reacts with HOG with the rate constant 5.1 × 109 dm3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbfcc19ba2007f9c399a46d32b00b36
https://doi.org/10.1016/s0891-5849(97)00203-7
https://doi.org/10.1016/s0891-5849(97)00203-7
Autor:
Peter Wardman, Medeleine F. Dennis, Michael R.L. Stratford, Steven A. Everett, Kantilal B. Patel
Publikováno v:
Journal of Chromatography A. 770:273-279
Putative free-radical intermediates in drug action can be studied by radiolysis of model systems containing low concentrations of drug and much higher concentrations of other solutes to scavenge the primary water radicals and convert them into approp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5374d75345f42e68ad0f39f179eb0a75
https://doi.org/10.1016/s0021-9673(96)01029-1
https://doi.org/10.1016/s0021-9673(96)01029-1
Autor:
Subhas C. Kundu, Madeleine F. Dennis, Robin L. Willson, Steven A. Everett, Kantilal B. Patel, S. Maddix
Publikováno v:
Journal of Biological Chemistry. 271:3988-3994
Mechanisms of free radical scavenging by the nutritional antioxidant beta-carotene have been investigated by pulse radiolysis. Free radicals, which can initiate the chain of lipid peroxidation, including nitrogen dioxide (NO2.), thiyl (RS.), and sulf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd739726649e77ddc3760062a649b27e
https://doi.org/10.1074/jbc.271.8.3988
https://doi.org/10.1074/jbc.271.8.3988