Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Steven A. Clarke"'
Autor:
Mei-Ling Yang, TuKiet T. Lam, Jean Kanyo, Insoo Kang, Zhaohui Sunny Zhou, Steven G. Clarke, Mark J. Mamula
Publikováno v:
Autoimmunity, Vol 56, Iss 1 (2023)
AbstractProtein posttranslational modifications (PTMs) arise in a number of normal cellular biological pathways and in response to pathology caused by inflammation and/or infection. Indeed, a number of PTMs have been identified and linked to specific
Externí odkaz:
https://doaj.org/article/66aeaf4b5d7541cb886063484f395615
Publikováno v:
PLoS ONE, Vol 18, Iss 12, p e0296291 (2023)
The methionine addiction of cancer cells is known as the Hoffman effect. While non-cancer cells in culture can utilize homocysteine in place of methionine for cellular growth, most cancer cells require exogenous methionine for proliferation. It has b
Externí odkaz:
https://doaj.org/article/028a12d643d74df0a971ec94632fa16b
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285812 (2023)
Mammalian protein arginine methyltransferase 7 (PRMT7) has been shown to target substrates with motifs containing two arginine residues separated by one other residue (RXR motifs). In particular, the repression domain of human histone H2B (29-RKRSR-3
Externí odkaz:
https://doaj.org/article/21513c637b304d3eabb26d725d9c91d7
Autor:
Yusuke Aoki, Qinghong Han, Yasunori Tome, Jun Yamamoto, Yutaro Kubota, Noriyuki Masaki, Koya Obara, Kazuyuki Hamada, Justin D. Wang, Sachiko Inubushi, Michael Bouvet, Steven G. Clarke, Kotaro Nishida, Robert M. Hoffman
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Methionine addiction, a fundamental and general hallmark of cancer, known as the Hoffman Effect, is due to altered use of methionine for increased and aberrant transmethylation reactions. However, the linkage of methionine addiction and malignancy of
Externí odkaz:
https://doaj.org/article/97c077fb9c4b486fa0ac8b7bb108f0b6
Autor:
Jun Yamamoto, Sachiko Inubushi, Qinghong Han, Yoshihiko Tashiro, Norihiko Sugisawa, Kazuyuki Hamada, Yusuke Aoki, Kentaro Miyake, Ryusei Matsuyama, Michael Bouvet, Steven G. Clarke, Itaru Endo, Robert M. Hoffman
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104162- (2022)
Summary: Methionine addiction, found in all types of cancer investigated, is because of the overuse of methionine by cancer cells for excess transmethylation reactions. In the present study, we compared the histone H3 lysine-methylation status and de
Externí odkaz:
https://doaj.org/article/406428cf8097463ba54fc0fc565fe04d
Autor:
Anita Ayer, Daniel J. Fazakerley, Cacang Suarna, Ghassan J. Maghzal, Diba Sheipouri, Kevin J. Lee, Michelle C. Bradley, Lucía Fernández-del-Rio, Sergey Tumanov, Stephanie MY. Kong, Jelske N. van der Veen, Andrian Yang, Joshua W.K. Ho, Steven G. Clarke, David E. James, Ian W. Dawes, Dennis E. Vance, Catherine F. Clarke, René L. Jacobs, Roland Stocker
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102127- (2021)
Mitochondrial energy production and function rely on optimal concentrations of the essential redox-active lipid, coenzyme Q (CoQ). CoQ deficiency results in mitochondrial dysfunction associated with increased mitochondrial oxidative stress and a rang
Externí odkaz:
https://doaj.org/article/e5e37048d10e4f0db080cc6d7d4696a3
Autor:
Rebeccah A. Warmack, David R. Boyer, Chih-Te Zee, Logan S. Richards, Michael R. Sawaya, Duilio Cascio, Tamir Gonen, David S. Eisenberg, Steven G. Clarke
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
In patients with sporadic Alzheimer’s disease part of the Asp23 residues are isomerized to L-isoaspartate (L-isoAsp23). Here the authors present the MicroED structures of wild-type and L-isoAsp23 Aβ 20–34 amyloid fibrils that both form tightly p
Externí odkaz:
https://doaj.org/article/13816496598043ba832e0e479cc32bd3
Autor:
Remon Soliman, Maria Lorena Cordero-Maldonado, Teresa G. Martins, Mahsa Moein, Jean-François Conrotte, Rebeccah A. Warmack, Alexander Skupin, Alexander D. Crawford, Steven G. Clarke, Carole L. Linster
Publikováno v:
Frontiers in Genetics, Vol 11 (2021)
Isomerization of l-aspartyl and l-asparaginyl residues to l-isoaspartyl residues is one type of protein damage that can occur under physiological conditions and leads to conformational changes, loss of function, and enhanced protein degradation. Prot
Externí odkaz:
https://doaj.org/article/acd904b14ec240748fb3a76b7e3b8d6d
Autor:
Mei-Ling Yang, Sean E. Connolly, Renelle J. Gee, TuKiet T. Lam, Jean Kanyo, Jian Peng, Perrin Guyer, Farooq Syed, Hubert M. Tse, Steven G. Clarke, Catherine F. Clarke, Eddie A. James, Cate Speake, Carmella Evans-Molina, Peter Arvan, Kevan C. Herold, Li Wen, Mark J. Mamula
Publikováno v:
Diabetes. 71:1979-1993
Inflammation and oxidative stress in pancreatic islets amplify the appearance of various posttranslational modifications to self-proteins. In this study, we identified a select group of carbonylated islet proteins arising before the onset of hypergly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a67a360622f1aba1f9c3f3e1caa19f49
https://doi.org/10.2337/db21-0989
https://doi.org/10.2337/db21-0989
Autor:
Rebeccah A. Warmack, Eric Z. Pang, Esther Peluso, Jonathan D. Lowenson, Joseph Y. Ong, Jorge Z. Torres, Steven G. Clarke
Publikováno v:
Biochemistry
The spontaneous L-isoaspartate protein modification has been observed to negatively affect protein function. However, this modification can be reversed in many proteins in reactions initiated by the protein-L-isoaspartyl (D-aspartyl) O-methyltransfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb4d40718752685f8d461498a77a9a2
https://doi.org/10.1021/acs.biochem.2c00130
https://doi.org/10.1021/acs.biochem.2c00130