Výsledky vyhledávání - "Steven A R Webb"

Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial

Autor: Patrick R. Lawler, Rob Fowler, Edward Litton, Colin McArthur, Katrina Orr, Ryan Zarychanski, Christopher W. Seymour, Richard Beasley, Herman Goossens, Timothy D. Girard, John C. Marshall, Rachael Parke, Marc J. M. Bonten, Susan C. Morpeth, Lennie P. G. Derde, Abi Beane, Steven Y. C. Tong, Alisa Higgins, Asad E. Patanwala, Jane C. Parker, Anna McGlothlin, Menno de Jong, Shay McGuinness, Stephanie K. Montgomery, Alistair Nichol, Frank L. van de Veerdonk, Zahra Bhimani, Christopher M. Horvat, Allen C. Cheng, Manu Shankar-Hari, Anthony C. Gordon, Ewan C. Goligher, Farah Al Beidh, Lise J Estcourt, Kelsey Linstrum, Salim Malakouti, Andrew J King, Michelle A. Detry, Bryan J. McVerry, Francois Lamontagne, Rashan Haniffa, Alexis F. Turgeon, Srinivas Murthy, Cameron Green, Yaseen M. Arabi, Paul R Mouncey, Lolowa Al Swaidan, Eamon Duffy, Lindsay R. Berry, Roger J. Lewis, Scott M. Berry, Kathryn M Rowan, Djillali Annane, Christina Saunders, Meredith Buxton, Mark Fitzgerald, Anne Turner, Elizabeth Lorenzi, Adrian Buzgau, Derek C. Angus, David T. Huang, Charlotte Bradbury, Steven A R Webb, Marlene Santos, Daniel F. McAuley, Thomas Hills, Frank M. Brunkhorst

Publikováno v: Intensive care medicine
Intensive Care Medicine, 47, 8, pp. 867-886
Investigators, REMAP-CAP & Dark, P 2021, ' Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial. ', Intensive care medicine, vol. 47, no. 8, pp. 867-886 . https://doi.org/10.1007/s00134-021-06448-5
2021, ' Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19 : REMAP-CAP randomized controlled trial ', Intensive Care Medicine, vol. 47, no. 8, pp. 867-886 . https://doi.org/10.1007/s00134-021-06448-5
Intensive care medicine, vol 47, iss 8
Arabi, Y M 2021, ' Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19 : REMAP-CAP randomized controlled trial ', Intensive Care Medicine, vol. 47, no. 8, pp. 867-886 . https://doi.org/10.1007/s00134-021-06448-5
Intensive Care Medicine, 47, 867-886
Intensive care medicine, 47(8), 867-886. Springer Verlag
INTENSIVE CARE MEDICINE
Intensive Care Medicine

Purpose To study the efficacy of lopinavir-ritonavir and hydroxychloroquine in critically ill patients with coronavirus disease 2019 (COVID-19). Methods Critically ill adults with COVID-19 were randomized to receive lopinavir-ritonavir, hydroxychloro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f60807238eec20d8d9a1e22139c92fa
https://doi.org/10.1007/s00134-021-06448-5

Zobrazit plný text záznamu

The REMAP-CAP (Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia) Study. Rationale and Design

Publikováno v: Annals of the American Thoracic Society
Annals of the American Thoracic Society, vol 17, iss 7
Proceedings of the American Thoracic Society
Annals of the American Thoracic Society, 17(7), 879-891. American Thoracic Society

There is broad interest in improved methods to generate robust evidence regarding best practice, especially in settings where patient conditions are heterogenous and require multiple concomitant therapies. Here, we present the rationale and design of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e6034412888a3fc7b082650d30eb1b
https://doi.org/10.1513/annalsats.202003-192sd

Zobrazit plný text záznamu

Embedding clinical trials within routine health‐care delivery: Challenges and opportunities

Autor: Annaleise R Howard-Jones, Steven A R Webb

Publikováno v: Journal of Paediatrics and Child Health

The COVID‐19 pandemic provides a pertinent reminder of the imperative to generate timely reliable clinical evidence. Delivery of optimal paediatric care is predicated on the availability of comprehensive, high quality, clinical evidence in a releva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f08171d4618b8c26719614d02ec06f8
https://doi.org/10.1111/jpc.15354

Zobrazit plný text záznamu

Glucocorticoid Dose in COVID-19: Lessons for Clinical Trials During a Pandemic

Autor: Alisa Higgins, Colin McArthur, Steven A R Webb

Publikováno v: JAMA

IMPORTANCE: A daily dose with 6 mg of dexamethasone is recommended for up to 10 days in patients with severe and critical COVID-19, but a higher dose may benefit those with more severe disease. OBJECTIVE: To assess the effects of 12 mg/d vs 6 mg/d of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe85a2c51859c2e0fcda353b72d42186
https://pubmed.ncbi.nlm.nih.gov/34673895

Zobrazit plný text záznamu

Normalising comparative effectiveness trials as clinical practice

Autor: William Tarnow-Mordi, Ian A. Harris, Tanya Symons, Alistair Nichol, John Simes, Tom Briffa, Edward Litton, Nicola Straiton, Nikolajs Zeps, Steven A R Webb, Melinda Cruz, Christopher M. Williams

Publikováno v: Trials
Trials, Vol 22, Iss 1, Pp 1-4 (2021)

There is a lack of high-quality evidence underpinning many contemporary clinical practice guidelines embedded in the healthcare systems, leading to treatment uncertainty and practice variation in most medical disciplines. Comparative effectiveness tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a6bce815a9de5dd77900799543c051
https://doi.org/10.1186/s13063-021-05566-1

Zobrazit plný text záznamu

Therapeutic Anticoagulation in Non-Critically Ill Patients with Covid-19

BackgroundThrombo-inflammation may contribute to morbidity and mortality in Covid-19. We hypothesized that therapeutic-dose anticoagulation may improve outcomes in non-critically ill patients hospitalized for Covid-19.MethodsIn an open-label adaptive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2eb87171a7317e44aafcf8e8a74bf242
https://doi.org/10.1101/2021.05.13.21256846

Zobrazit plný text záznamu

Therapeutic Anticoagulation in Critically Ill Patients with Covid-19 – Preliminary Report

BackgroundThrombosis may contribute to morbidity and mortality in Covid-19. We hypothesized that therapeutic anticoagulation would improve outcomes in critically ill patients with Covid-19.MethodsWe conducted an open-label, adaptive, multiplatform, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf92249cb690a3cb4c5acba19996454f
https://doi.org/10.1101/2021.03.10.21252749

Zobrazit plný text záznamu

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis

Publikováno v: Sterne, J A C, Murthy, S, Diaz, J, Slutsky, A S, Villar, J, Angus, D C, Annane, D, Azevedo, L C P, Berwanger, O, B Cavalcanti, A, Dequin, P-F, Du, B, Emberson, J R, Fisher, D, Giraudeau, B, Gordon, A C, Granholm, A, Green, C, Haynes, R, Heming, N, Higgins, J P T, Horby, P, Juni, P, Landray, M J, Le Gouge, A, Leclerc, M, Lim, W S, R Machado, F, McArthur, C, Meziani, F, Møller, M H, Perner, A, Petersen, M W, Savović, J, Tomazini, B, C Veiga, V, Webb, S & C Marshall, J 2020, ' Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 : A Meta-analysis ', JAMA-Journal of the American Medical Association, vol. 324, no. 13, pp. 1330-1341 . https://doi.org/10.1001/jama.2020.17023
JAMA

IMPORTANCE: Effective therapies for patients with coronavirus disease 2019 (COVID-19) are needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced mortality in hospitalized patients with COVID-19 who required respiratory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d64618bb6a97bf6370055fc074fc5a
https://pubmed.ncbi.nlm.nih.gov/33844805

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání