Zobrazeno 1 - 10
of 330
pro vyhledávání: '"Steven A Porcelli"'
Autor:
Lisa N Glass, Ganduri Swapna, Sivagami Sundaram Chavadi, JoAnn M Tufariello, Kaixia Mi, Joshua E Drumm, TuKiet T Lam, Guofeng Zhu, Chenyang Zhan, Catherine Vilchéze, Jesus Arcos, Yong Chen, Lijun Bi, Simren Mehta, Steven A Porcelli, Steve C Almo, Syun-Ru Yeh, William R Jacobs, Jordi B Torrelles, John Chan
Publikováno v:
PLoS Pathogens, Vol 13, Iss 7, p e1006515 (2017)
We have previously shown that the Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth and may be required for the establishment of tuberculous persistence. Here, yeast two-hybrid and affinity chromatography exper
Externí odkaz:
https://doaj.org/article/6d48c6ed73d94b888c9e8814f3059ad9
Autor:
Rafael Prados-Rosales, Leandro Carreño, Tingting Cheng, Caroline Blanc, Brian Weinrick, Adel Malek, Todd L Lowary, Andres Baena, Maju Joe, Yu Bai, Rainer Kalscheuer, Ana Batista-Gonzalez, Noemi A Saavedra, Leticia Sampedro, Julen Tomás, Juan Anguita, Shang-Cheng Hung, Ashish Tripathi, Jiayong Xu, Aharona Glatman-Freedman, Williams R Jacobs, John Chan, Steven A Porcelli, Jacqueline M Achkar, Arturo Casadevall
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006250 (2017)
Currently there are a dozen or so of new vaccine candidates in clinical trials for prevention of tuberculosis (TB) and each formulation attempts to elicit protection by enhancement of cell-mediated immunity (CMI). In contrast, most approved vaccines
Externí odkaz:
https://doaj.org/article/05a00e1f415147c2a37c636bd2ccbc98
Autor:
Thi Kim Anh Nguyen, Peter Reinink, Chema El Messlaki, Jin S Im, Altan Ercan, Steven A Porcelli, Ildiko Van Rhijn
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121923 (2015)
Research addressing the in vivo effects of T cell activation by lipids, glycolipids, and lipopeptides is hampered by the absence of a suitable animal model. Mice and rats do not express CD1a, CD1b, and CD1c molecules that present pathogen-derived lip
Externí odkaz:
https://doaj.org/article/3c8411347f594427ae265214284fc383
Autor:
Thi Kim Anh Nguyen, Peter Reinink, Chema El Messlaki, Jin S Im, Altan Ercan, Steven A Porcelli, Ildiko Van Rhijn
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129755 (2015)
Externí odkaz:
https://doaj.org/article/c13046cb5d404439a1fb8831e8355f7b
Autor:
Daniel Paletta, Alina Suzann Fichtner, Lisa Starick, Steven A Porcelli, Paul B Savage, Thomas Herrmann
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143449 (2015)
CD1d molecules are MHC class I-like molecules that present glycolipids to iNKT cells. The highly conserved interaction between CD1d:α-Galactosylceramide (αGC) complexes and the iNKT TCR not only defines this population of αβ T cells but can also
Externí odkaz:
https://doaj.org/article/91d18be1127f401082f4ced557b38707
Autor:
Manjunatha M Venkataswamy, Tony W Ng, Shalu S Kharkwal, Leandro J Carreño, Alison J Johnson, Shajo Kunnath-Velayudhan, Zheng Liu, Robert Bittman, Peter J Jervis, Liam R Cox, Gurdyal S Besra, Xiangshu Wen, Weiming Yuan, Moriya Tsuji, Xiangming Li, David D Ho, John Chan, Sunhee Lee, Richard Frothingham, Barton F Haynes, Michael W Panas, Geoffrey O Gillard, Jaimie D Sixsmith, Birgit Korioth-Schmitz, Joern E Schmitz, Michelle H Larsen, William R Jacobs, Steven A Porcelli
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108383 (2014)
Recombinant Mycobacterium bovis bacillus Calmette-Guèrin (rBCG) has been explored as a vector for vaccines against HIV because of its ability to induce long lasting humoral and cell mediated immune responses. To maximize the potential for rBCG vacci
Externí odkaz:
https://doaj.org/article/90e45a31ded54c5cbca2c3231d0f0e54
Autor:
Tony W. Ng, Wakako Furuyama, Ariel S. Wirchnianski, Noemí A. Saavedra-Ávila, Christopher T. Johndrow, Kartik Chandran, William R. Jacobs, Andrea Marzi, Steven A. Porcelli
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Previous studies have demonstrated the efficacy and feasibility of an anti-viral vaccine strategy that takes advantage of pre-existing CD4+ helper T (Th) cells induced by Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccination. This strategy u
Externí odkaz:
https://doaj.org/article/f8873c18c52a478ba7ece8617e9ee5b6
Autor:
Lee Kozakiewicz, Yong Chen, Jiayong Xu, Yanhua Wang, Kyri Dunussi-Joannopoulos, Qinglin Ou, Joanne L Flynn, Steven A Porcelli, William R Jacobs, John Chan
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003472 (2013)
We have previously demonstrated that B cells can shape the immune response to Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous inflammation at the site of infection. The present study examined the mechanism
Externí odkaz:
https://doaj.org/article/e5b72bf06e27438e9351c7e4a52d048d
Autor:
Vincent O'Reilly, Shijuan G Zeng, Gabriel Bricard, Ann Atzberger, Andrew E Hogan, John Jackson, Conleth Feighery, Steven A Porcelli, Derek G Doherty
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28648 (2011)
CD1d-restricted invariant natural killer T (iNKT) cells have diverse immune stimulatory/regulatory activities through their ability to release cytokines and to kill or transactivate other cells. Activation of iNKT cells can protect against multiple d
Externí odkaz:
https://doaj.org/article/f376d408fe7e4645bb0c0964f1f6a6b3
Autor:
Joseph Hinchey, Bo Y Jeon, Holly Alley, Bing Chen, Michael Goldberg, Steven Derrick, Sheldon Morris, William R Jacobs, Steven A Porcelli, Sunhee Lee
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15857 (2011)
Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a major global health problem, despite the widespread use of the M. bovis Bacille Calmette-Guerin (BCG) vaccine and the availability of drug therapies. In recent years, the high incidence
Externí odkaz:
https://doaj.org/article/c034d684fb4b4f2ca5d7da3def0281a1