Zobrazeno 1 - 10
of 197
pro vyhledávání: '"Steven A Johnsen"'
Autor:
Evangelos Prokakis, Husam Bamahmoud, Shaishavi Jansari, Lena Fritsche, Alexander Dietz, Angela Boshnakovska, Peter Rehling, Steven A. Johnsen, Julia Gallwas, Florian Wegwitz
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Breast cancer (BC) is the most frequent tumor entity in women worldwide with a high chance of therapeutic response in early- and non-metastatic disease stages. Among all BC subtypes, triple-negative BC (TNBC) is the most challengi
Externí odkaz:
https://doaj.org/article/f99aa535c8c1441896abb3b0036937e9
Autor:
Laura K. Godfrey, Jan Forster, Sven-Thorsten Liffers, Christopher Schröder, Johannes Köster, Leonie Henschel, Kerstin U. Ludwig, David Lähnemann, Marija Trajkovic-Arsic, Diana Behrens, Aldo Scarpa, Rita T. Lawlor, Kathrin E. Witzke, Barbara Sitek, Steven A. Johnsen, Sven Rahmann, Bernhard Horsthemke, Michael Zeschnigk, Jens T. Siveke
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-22 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis. It is marked by extraordinary resistance to conventional therapies including chemotherapy and radiation, as well as to essentially all targeted t
Externí odkaz:
https://doaj.org/article/d600d9b4f409474cb363cc7b8d335cf3
Autor:
Vijayalakshmi Kari, Oleksandra Karpiuk, Bettina Tieg, Malte Kriegs, Ekkehard Dikomey, Heike Krebber, Yvonne Begus-Nahrmann, Steven A Johnsen
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63745 (2013)
Unlike other metazoan mRNAs, replication-dependent histone gene transcripts are not polyadenylated but instead have a conserved stem-loop structure at their 3' end. Our previous work has shown that under certain conditions replication-dependent histo
Externí odkaz:
https://doaj.org/article/4b61d1df694d494eac1d9c077cfa29ef
Autor:
Steven A Johnsen
Publikováno v:
PLoS Genetics, Vol 8, Iss 8, p e1002860 (2012)
Externí odkaz:
https://doaj.org/article/dddebca88bb749efb1366fab66fc5ef7
Autor:
Evangelos Prokakis, Shaishavi Jansari, Angela Boshnakovska, Maria Wiese, Kathrin Kusch, Christof Kramm, Christian Dullin, Peter Rehling, Markus Glatzel, Klaus Pantel, Harriet Wikman, Steven A. Johnsen, Julia Gallwas, Florian Wegwitz
Publikováno v:
Cell Death and Disease, Vol 14, Iss 9, Pp 1-17 (2023)
Abstract Triple-negative breast cancer (TNBC) is the most difficult breast cancer subtype to treat due to the lack of targeted therapies. Cancer stem cells (CSCs) are strongly enriched in TNBC lesions and are responsible for the rapid development of
Externí odkaz:
https://doaj.org/article/45a4565c3aba4ddb93e42ef339891e35
Autor:
Zhe Zhang, Xin Wang, Feda H. Hamdan, Anna Likhobabina, Shilpa Patil, Lena Aperdannier, Madhobi Sen, Jacobe Traub, Albrecht Neesse, André Fischer, Argyris Papantonis, Shiv K. Singh, Volker Ellenrieder, Steven A. Johnsen, Elisabeth Hessmann
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 5, Pp 1219-1246 (2023)
Background & Aims: Loss of AT-rich interactive domain-containing protein 1A (ARID1A) fosters acinar-to-ductal metaplasia (ADM) and pancreatic carcinogenesis by down-regulating transcription programs controlling acinar cell identity. However, how ARID
Externí odkaz:
https://doaj.org/article/eb30d11bebe1451192c01dfee4b0bc4b
Autor:
Feda H Hamdan, Amro M Abdelrahman, Ana Patricia Kutschat, Xin Wang, Thomas L Ekstrom, Nidhi Jalan-Sakrikar, Catherine Wegner Wippel, Negar Taheri, Liezel Tamon, Waltraut Kopp, Joana Aggrey-Fynn, Aditya V Bhagwate, Roberto Alva-Ruiz, Isaac Lynch, Jennifer Yonkus, Robyn Laura Kosinsky, Jochen Gaedcke, Stephan A Hahn, Jens T Siveke, Rondell Graham, Zeynab Najafova, Elisabeth Hessmann, Mark J Truty, Steven A Johnsen
Publikováno v:
Gut. 72:1174-1185
ObjectivePancreatic ductal adenocarcinoma (PDAC) displays a remarkable propensity towards therapy resistance. However, molecular epigenetic and transcriptional mechanisms enabling this are poorly understood. In this study, we aimed to identify novel
Autor:
Harriet Wikman, Klaus Pantel, Volkmar Müller, Matthias Wilmanns, Juha Klefström, Steven A. Johnsen, Andreas Trumpp, Tanja Fehm, Roland Eils, Manfred Jücker, Irène Baccelli, Upasana Bedi, Sabine Riethdorf, Thomas Streichert, Hans Neubauer, Henrik Edgren, Antony W. Wood, Dirk Kemming, Annabel Parret, Vivian Pogenberg, Elsa Marques, Julia Eick, Benedikt Brors, Stefan Werner
Supplementary Figure S4. Data base analysis of correlation between RAI2 and ESR1 mRNA expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3238add4da5bcb6677d30c31a1a11f56
https://doi.org/10.1158/2159-8290.22530410
https://doi.org/10.1158/2159-8290.22530410
Autor:
Marian Grade, Thomas Ried, Steven A. Johnsen, B. Michael Ghadimi, Jochen Gaedcke, Elisabeth Heßmann, Margret Rave-Fränk, Hendrik A. Wolff, Tim Beissbarth, Yue Hu, Frank Kramer, Noam Auslander, Janneke Möller, Sebastian Reineke, Melanie Spitzner, Georg Emons
Plating efficiencies of cells before and after treatment with siRNAs and XAV-939, stimulation with Wnt-3a, overexpression of mutated β-catenin (S33Y) and SW1463 becoming radiation resistant. (A) Plating efficiencies for RT, (B) plating efficiencies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e9c0e85c2ea629fe634cdd3534b6ac6
https://doi.org/10.1158/1541-7786.22511700
https://doi.org/10.1158/1541-7786.22511700
Autor:
Marian Grade, Thomas Ried, Steven A. Johnsen, B. Michael Ghadimi, Jochen Gaedcke, Elisabeth Heßmann, Margret Rave-Fränk, Hendrik A. Wolff, Tim Beissbarth, Yue Hu, Frank Kramer, Noam Auslander, Janneke Möller, Sebastian Reineke, Melanie Spitzner, Georg Emons
Western blot analysis of (A) SW480, (B) SW837, and (C) RPE-1 cells after exposure to various doses of XAV-939 and DMSO as negative control.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c1807b3f1633d3084a3a3c86d134ae
https://doi.org/10.1158/1541-7786.22511727.v1
https://doi.org/10.1158/1541-7786.22511727.v1