Zobrazeno 1 - 10
of 1 136
pro vyhledávání: '"Steven A, Narod"'
Autor:
Marta Seca, Steven A. Narod
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 22, Iss 1, Pp 1-5 (2024)
Abstract Genetic testing for breast cancer predisposing genes has expanded beyond BRCA1 and BRCA2 and now includes panels of 20 or more genes. It is now recommended that all women diagnosed with breast cancer at age 65 or below be offered testing for
Externí odkaz:
https://doaj.org/article/d8f1cd964c4242e6b7f3d8dfe72fe4ba
Autor:
Holly J. Pederson, Steven A. Narod
Publikováno v:
BJC Reports, Vol 2, Iss 1, Pp 1-9 (2024)
Abstract It is thirty years since the BRCA1 and BRCA2 genes were discovered and genetic testing for BRCA1 and BRCA2 was introduced. Despite increasing awareness of the genetic basis of cancer and our evolving knowledge of effective means of preventio
Externí odkaz:
https://doaj.org/article/ab170bedf28d4d5a8cac336e279d988b
Autor:
Aghaghia Mokhber, Elizabeth Hall, Aleksandra Uzelac, Leonardo Salmena, Angela Cheung, Jan Lubinski, Steven A. Narod, Joanne Kotsopoulos
Publikováno v:
Bone Reports, Vol 22, Iss , Pp 101802- (2024)
Purpose: Osteoprotegerin (OPG) plays an important role in the inhibition of osteoclast formation and bone resorption. Studies have reported lower OPG levels among women with a pathogenic variant (mutation) in the BRCA1 gene, and thus, may be at great
Externí odkaz:
https://doaj.org/article/28e8e471945442a7b829bdda7e82c69e
Autor:
Steven A. Narod, Kelly Metcalfe, Amy Finch, An-Wen Chan, Susan Randall Armel, Amber Aeilts, Andrea Eisen, Beth Karlan, Louise Bordeleau, Nadine Tung, William D. Foulkes, Susan L. Neuhausen, Charis Eng, Olufunmilayo Olopade, Dana Zakalik, Fergus Couch, Carey Cullinane, Tuya Pal, Ping Sun, Joanne Kotsopoulos, the Hereditary Breast Cancer Clinical Research Group
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 22, Iss 1, Pp 1-7 (2024)
Abstract Background It has not been clearly established if skin cancer or melanoma are manifestations of BRCA1 or BRCA2 mutation carrier status. Estimating the risk of skin cancer is an important step towards developing screening recommendations. Met
Externí odkaz:
https://doaj.org/article/a378e2ed8eef4e5da2188174c7dbe392
Autor:
Erin Sellars, Margarita Savguira, Jie Wu, Sabrina Cancelliere, Mark Jen, Rehna Krishnan, Anne Hakem, Dalia Barsyte-Lovejoy, Razqallah Hakem, Steven A. Narod, Joanne Kotsopoulos, Leonardo Salmena
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110180- (2024)
Summary: PARP inhibitors (PARPi) are efficacious in BRCA1-null tumors; however, their utility is limited in tumors with functional BRCA1. We hypothesized that pharmacologically reducing BRCA1 protein levels could enhance PARPi effectiveness in BRCA1
Externí odkaz:
https://doaj.org/article/bcb9003f4dde4e0eb521298681341c30
Autor:
Steven A. Narod
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 21, Iss 1, Pp 1-4 (2023)
Abstract With widespread testing for susceptibility genes, increasing numbers of women are being identified to carry a mutation in one of many genes which renders them susceptible to cancer. The first gene to be identified (in 1994) was BRCA1 which i
Externí odkaz:
https://doaj.org/article/d86121aaf9054ec0b0af3870c92a3f28
Publikováno v:
Cancer Medicine, Vol 12, Iss 19, Pp 19921-19934 (2023)
Abstract Background The survival of women with early‐stage breast cancer varies by racial group. Filipino women with breast cancer are an understudied group and are often combined with other Asian groups. We compared clinical presentations and surv
Externí odkaz:
https://doaj.org/article/61f29adf6140436aaff888898f3dee0b
Autor:
Kelly A. Metcalfe, Tuya Pal, Steven A. Narod, Susan Armel, Salma Shickh, Kathleen Buckley, Scott T. Walters, Sarah Brennenstuhl, Anita Y. Kinney
Publikováno v:
Cancer Medicine, Vol 12, Iss 17, Pp 18246-18257 (2023)
Abstract Objective To evaluate the effect of a theory‐based behavioral intervention delivered by genetic counselors on the uptake of risk‐reducing salpingo‐oophorectomy (RRSO) at 12 and 24 months by women with a BRCA1 or BRCA2 pathogenic varian
Externí odkaz:
https://doaj.org/article/3d630fad647649d8b2ca75d271b70fb0
Publikováno v:
Current Oncology, Vol 30, Iss 4, Pp 3829-3844 (2023)
Background: Many women with early-stage breast cancer are predicted to be at sufficiently low risk for recurrence that they may forego chemotherapy. Nevertheless, some low-risk women will experience a local recurrence, and for them the risk of death
Externí odkaz:
https://doaj.org/article/196c8750d9d040eb8599ec1dd7934765
Autor:
Kelly A. Metcalfe, Steven A. Narod, Andrea Eisen, Aletta Poll, Neda Zamani, David McCready, Tulin D. Cil, Frances C. Wright, Jordan Lerner‐Ellis, Jeanna McCuaig, Tracy Graham, Ping Sun, Mohammad R. Akbari
Publikováno v:
Cancer Medicine, Vol 12, Iss 6, Pp 7580-7587 (2023)
Abstract Background Knowledge of pathogenic variants in cancer‐predisposing genes is important when making breast cancer treatment decisions, but genetic testing is not universal and criteria must be met to qualify for genetic testing. The objectiv
Externí odkaz:
https://doaj.org/article/3a9f267784544d13b9ad338f63cefc19