Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Steven A, Krilis"'
Βeta 2-glycoprotein I protects mice against gram-negative septicaemia in a sexually dimorphic manner
Autor:
Fatima El-Assaad, Miao Qi, Alice Kizny Gordon, Jian Qi, Shangwen Dong, Freda Passam, James Crofton Weaver, Bill Giannakopoulos, Steven Anthony Krilis
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The immune responses of males and females to bacterial infections display differences. The mechanisms that underlie this sexual dimorphism are multifactorial. Lipopolysaccharide (LPS) contributes to the pathogenesis of endotoxaemia. We have
Externí odkaz:
https://doaj.org/article/231b190675f34a56a24c456b8f06d775
Autor:
M. Qi, Leonard Kritharides, Maaike Kockx, Inaam Ullah, James C. Weaver, Bill Giannakopoulos, Kerry-Anne Rye, Steven A. Krilis
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 40:2794-2804
Objective: Atherosclerotic coronary artery disease is well recognised as an inflammatory disorder that is also influenced by oxidative stress. β2-GPI (β-2-glycoprotein-I) is a circulating plasma protein that undergoes post-translational modificatio
Autor:
Saijun Zhou, Kumiko Tanaka, Meredith O'Keeffe, Miao Qi, Fatima El-Assaad, James C Weaver, Gang Chen, Christopher Weatherall, Ying Wang, Bill Giannakopoulos, Liming Chen, DeMint Yu, Matthew J Hamilton, Lislaine A Wensing, Richard L Stevens, Steven A Krilis
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151638 (2016)
Ras guanine nucleotide-releasing protein-4 (RasGRP4) is an evolutionarily conserved calcium-regulated, guanine nucleotide exchange factor and diacylglycerol/phorbol ester receptor. While an important intracellular signaling protein for CD117+ mast ce
Externí odkaz:
https://doaj.org/article/604be3906ec4491ea39b0b5d915850be
Autor:
Peng Zhang, James C Weaver, Gang Chen, Julia Beretov, Tatsuya Atsumi, Miao Qi, Ravinay Bhindi, Jian C Qi, Michele C Madigan, Bill Giannakopoulos, Steven A Krilis
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152681 (2016)
Reperfusion after a period of ischemia results in reperfusion injury (IRI) which involves activation of the inflammatory cascade. In cardiac IRI, IgM natural antibodies (NAb) play a prominent role through binding to altered neoepitopes expressed on d
Externí odkaz:
https://doaj.org/article/9abaf199061541dab78dd488bcc47df2
Autor:
Soheila Rahgozar, Tayebeh Amirian, Miao Qi, Zahra Shahshahan, Mansureh Entezar-E-Ghaem, Hatav Ghasemi Tehrani, Mehran Miroliaei, Steven A Krilis, Bill Giannakopoulos
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135905 (2015)
Angiotensinogen exists in two distinct redox forms in plasma, the oxidized sulfhydryl-bridge form and the reduced, unbridged, free thiol form. The oxidized form of angiotensinogen compared to the free thiol form preferentially interacts with renin re
Externí odkaz:
https://doaj.org/article/4fb717b0ab144757a1377806bdf400aa
Publikováno v:
Journal of Autoimmunity. 126:102747
Little is known about the physiological role of beta-2-glycoprotein I (β2GPI) despite it being the major auto-antigen in the antiphospholipid syndrome. A systematic study of the role of β2GPI in thrombus formation in vivo has not been performed to
Publikováno v:
Phospholipid-Binding Antibodies ISBN: 9780429278129
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f4b64aa077f7d3b311e30da68212ce2
https://doi.org/10.1201/9780429278129-15
https://doi.org/10.1201/9780429278129-15
β2GPI exerts an anti-obesity effect in female mice by inhibiting lipogenesis and promoting lipolysis
Autor:
Liming Chen, M. Qi, Steven Antony Krilis, James C. Weaver, Shangwen Dong, Bill Giannakopoulos, Ying Wang
Publikováno v:
Oncotarget
// Shangwen Dong 1, 2 , Miao Qi 1 , Ying Wang 1, 3 , Liming Chen 3 , James Crofton Weaver 4 , Steven Antony Krilis 1, * and Bill Giannakopoulos 1, 5, * 1 Department of Infectious Diseases, Immunology and Sexual Health and Department of Medicine, St G
Autor:
H. M. Moutsopoulos, Beng H. Chong, Bill Giannakopoulos, A. Sturgess, Takao Koike, Yiannis Ioannou, M. Krilis, Z. Ahmadi, Jing-Yun Zhang, Jason W. H. Wong, Steven A. Krilis, M. Qi, Panayiotis G. Vlachoyiannopoulos
Publikováno v:
Journal of Autoimmunity. 122:102675
Β2-Glycoprotein I (β2GPI) is an important anti-thrombotic protein and is the major auto-antigen in the antiphospholipid syndrome (APS). The clinical relevance of nitrosative stress in post translational modification of β2GPI was examined.The effec
Autor:
Steven A. Krilis, Lislaine A. Wensing, G. William Wong, Philip M. Hansbro, Kichul Shin, H. Patrick McNeil, Richard L. Stevens
Publikováno v:
Journal of Biological Chemistry. 292:5392-5404
© 2017 by The American Society for Biochemistry and Molecular Biology, Inc. The constitutive heparin+ (HP) mast cells (MCs) in mice express mouseMCprotease (mMCP)-5 and carboxypeptidaseA (mMC-CPA). The amino acid sequence ofmMCP-5is most similar to