Zobrazeno 1 - 10 of 54 pro vyhledávání: '"Steven A, Haney"'
1
Akademický článek
Peak emission wavelength and fluorescence lifetime are coupled in far-red, GFP-like fluorescent proteins.
Autor: Laura Canty, Santosh Hariharan, Qian Liu, Steven A Haney, David W Andrews
Publikováno v: PLoS ONE, Vol 13, Iss 11, p e0208075 (2018)
The discovery and use of fluorescent proteins revolutionized cell biology by allowing the visualization of proteins in living cells. Advances in fluorescent proteins, primarily through genetic engineering, have enabled more advanced analyses, includi
Externí odkaz: https://doaj.org/article/4c805a626c314dce847f3ba9a4196a04
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3
Akademický článek
siRNA off-target effects can be reduced at concentrations that match their individual potency.
Autor: Daniel R Caffrey, Juan Zhao, Zhili Song, Michael E Schaffer, Steven A Haney, Romesh R Subramanian, Albert B Seymour, Jason D Hughes
Publikováno v: PLoS ONE, Vol 6, Iss 7, p e21503 (2011)
Small interfering RNAs (siRNAs) are routinely used to reduce mRNA levels for a specific gene with the goal of studying its function. Several studies have demonstrated that siRNAs are not always specific and can have many off-target effects. The 3' UT
Externí odkaz: https://doaj.org/article/80e4e30b2ce941189f40e0e34dd04ae8
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4
High-Content Screening Approaches That Minimize Confounding Factors in RNAi, CRISPR, and Small Molecule Screening
Autor: Steven A, Haney
Publikováno v: Methods in molecular biology (Clifton, N.J.). 1683
Screening arrayed libraries of reagents, particularly small molecules began as a vehicle for drug discovery, but the in last few years it has become a cornerstone of biological investigation, joining RNAi and CRISPR as methods for elucidating functio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4f5f81a4b9ed0b90d6447e344819f6cd
https://pubmed.ncbi.nlm.nih.gov/29082490
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5
Elektronická kniha
An Introduction To High Content Screening : Imaging Technology, Assay Development, and Data Analysis in Biology and Drug Discovery
Autor: Steven A. Haney, Douglas Bowman, Arijit Chakravarty, Anthony Davies, Caroline Shamu
Using a collaborative and interdisciplinary author base with experience in the pharmaceutical industry and academia, this book is a practical resource for high content (HC) techniques. • Instructs readers on the fundamentals of high content screen
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6
Expanding the repertoire of RNA interference screens for developing new anticancer drug targets
Autor: Steven A Haney
Publikováno v: Expert Opinion on Therapeutic Targets. 11:1429-1441
RNA interference (RNAi) screening for cancer drug target identification has been growing, in both the number of laboratories carrying out screens and in the scale of the screens themselves, from the first screens that were published a few years ago.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e29bab254091bc59d0c98e4278f4a9d
https://doi.org/10.1517/14728222.11.11.1429
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9
Anticancer drug development incorporating high-content screening and RNAi: synergistic approaches to improve target identification and validation
Autor: Steven A Haney
Publikováno v: Expert Opinion on Drug Discovery. 1:19-29
RNA interference (RNAi) and high-content screening (HCS) are powerful technologies that have converged on the early drug discovery process within the last year. RNAi emerged from basic science, where it has become a standard and accepted method for e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd10a047c9d87eb19578f6cb1407f05b
https://doi.org/10.1517/17460441.1.1.19
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