Zobrazeno 1 - 10
of 744
pro vyhledávání: '"Steven A, Carr"'
Autor:
Claudia Ctortecka, Natalie M. Clark, Brian W. Boyle, Anjali Seth, D. R. Mani, Namrata D. Udeshi, Steven A. Carr
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The recent technological and computational advances in mass spectrometry-based single-cell proteomics have pushed the boundaries of sensitivity and throughput. However, reproducible quantification of thousands of proteins within a single cel
Externí odkaz:
https://doaj.org/article/4d02495bf4d1442abd1b1edc2b329525
Autor:
Qiuyu Martin Zhu, Yu-Han H. Hsu, Frederik H. Lassen, Bryan T. MacDonald, Stephanie Stead, Edyta Malolepsza, April Kim, Taibo Li, Taiji Mizoguchi, Monica Schenone, Gaelen Guzman, Benjamin Tanenbaum, Nadine Fornelos, Steven A. Carr, Rajat M. Gupta, Patrick T. Ellinor, Kasper Lage
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Population-based association studies have identified many genetic risk loci for coronary artery disease (CAD), but it is often unclear how genes within these loci are linked to CAD. Here, we perform interaction proteomics for 11 CAD-risk gen
Externí odkaz:
https://doaj.org/article/33f24fe85b5e427da89e1cdd0af7dd9f
Autor:
Taylor Hanta Nagai, Chrissy Hartigan, Taiji Mizoguchi, Haojie Yu, Amy Deik, Kevin Bullock, Yanyan Wang, Debra Cromley, Monica Schenone, Chad A. Cowan, Daniel J. Rader, Clary B. Clish, Steven A. Carr, Yu-Xin Xu
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Biallelic mutations of the chromatin regulator SMARCAL1 cause Schimke Immunoosseous Dysplasia (SIOD), characterized by severe growth defects and premature mortality. Atherosclerosis and hyperlipidemia are common among SIOD patients, yet thei
Externí odkaz:
https://doaj.org/article/5a3eb819bb994b9f990ffb946a358df4
Autor:
Steven M. Carr
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Previous morpho-molecular studies of evolutionary relationships within the economically important genus of honey bees (Apis), including the Western Honey Bee (A. mellifera L.), have suggested Out of Africa or Asia origins and subsequent spre
Externí odkaz:
https://doaj.org/article/ac24791a32bd49c29ddff91af7ca86e7
Autor:
Shira Weingarten-Gabbay, Da-Yuan Chen, Siranush Sarkizova, Hannah B. Taylor, Matteo Gentili, Gabrielle M. Hernandez, Leah R. Pearlman, Matthew R. Bauer, Charles M. Rice, Karl R. Clauser, Nir Hacohen, Steven A. Carr, Jennifer G. Abelin, Mohsan Saeed, Pardis C. Sabeti
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113596- (2024)
Summary: Targeted synthetic vaccines have the potential to transform our response to viral outbreaks, yet the design of these vaccines requires a comprehensive knowledge of viral immunogens. Here, we report severe acute respiratory syndrome coronavir
Externí odkaz:
https://doaj.org/article/db8ea015b89d430fb372f8118aea4ea2
Autor:
Elisabet Manasanch, Hannah Taylor, Gabrielle M Hernandez, Eva K Verzani, Claudia Ctortecka, David A Berrios Nolasco, Karl R Clauser, Namrata D Udeshi, Jennifer G Abelin, Steven A Carr
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/e7b07ad65578471a985b7cbe13da9d64
Autor:
Jennifer G. Abelin, Erik J. Bergstrom, Keith D. Rivera, Hannah B. Taylor, Susan Klaeger, Charles Xu, Eva K. Verzani, C. Jackson White, Hilina B. Woldemichael, Maya Virshup, Meagan E. Olive, Myranda Maynard, Stephanie A. Vartany, Joseph D. Allen, Kshiti Phulphagar, M. Harry Kane, Suzanna Rachimi, D. R. Mani, Michael A. Gillette, Shankha Satpathy, Karl R. Clauser, Namrata D. Udeshi, Steven A. Carr
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Patient samples are often available in limited amounts, restricting the number of possible omics analyses. Here the authors present MONTE, a workflow that enables serial HLA-I and HLA-II immunopeptidome, ubiquitylome, proteome, phosphoproteome, and a
Externí odkaz:
https://doaj.org/article/2cb22e1fb42e4c8ab1737bea5ee8836a
Autor:
Matteo Gentili, Bingxu Liu, Malvina Papanastasiou, Deborah Dele-Oni, Marc A. Schwartz, Rebecca J. Carlson, Aziz M. Al’Khafaji, Karsten Krug, Adam Brown, John G. Doench, Steven A. Carr, Nir Hacohen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
STING is an intracellular sensor of pathogen- or host-derived DNA. In this study, the authors identify an ESCRT complex that regulates STING degradation, thus acting as a homeostatic regulator of STING signalling and type-I interferon responses.
Externí odkaz:
https://doaj.org/article/d27c75d5f7194b308e5471c9ab586aee
Autor:
Shanye Yin, Susan Klaeger, Vipheaviny A. Chea, Isabel P. Carulli, Suzanna Rachimi, Katharine E. Black, Michael Filbin, Lida P. Hariri, Rachel S. Knipe, Robert F. Padera, Jonathan D. Stevens, William J. Lane, Steven A. Carr, Catherine J. Wu, Edy Yong Kim, Derin B. Keskin
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSevere respiratory illness is the most prominent manifestation of patients infected with SARS-CoV-2, and yet the molecular mechanisms underlying severe lung disease in COVID-19 affected patients still require elucidation. Human leukocyte
Externí odkaz:
https://doaj.org/article/ee4599fa483940c28a9eb682e3174098
Autor:
Sho Sato, Michael Gillette, Pamela R. de Santiago, Eric Kuhn, Michael Burgess, Kristen Doucette, Yi Feng, Carlos Mendez-Dorantes, Paul J. Ippoliti, Sara Hobday, Marilyn A. Mitchell, Kai Doberstein, Stefan M. Gysler, Michelle S. Hirsch, Lauren Schwartz, Michael J. Birrer, Steven J. Skates, Kathleen H. Burns, Steven A. Carr, Ronny Drapkin
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Long interspersed element 1 (LINE-1) open reading frame 1 protein (ORF1p) expression is a common feature of many cancer types, including high-grade serous ovarian carcinoma (HGSOC). Here, we report that ORF1p is not only expressed but also r
Externí odkaz:
https://doaj.org/article/4b43d6de805a4bc5b6fd254961a19c5f