Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Steven McKinney"'
Autor:
Peter Eirew, Ciara O’Flanagan, Jerome Ting, Sohrab Salehi, Jazmine Brimhall, Beixi Wang, Justina Biele, Teresa Algara, So Ra Lee, Corey Hoang, Damian Yap, Steven McKinney, Cherie Bates, Esther Kong, Daniel Lai, Sean Beatty, Mirela Andronescu, Elena Zaikova, Tyler Funnell, Nicholas Ceglia, Stephen Chia, Karen Gelmon, Colin Mar, Sohrab Shah, Andrew Roth, Alexandre Bouchard-Côté, Samuel Aparicio
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Gene fitness and essentiality analyses using in vivo cancer models are challenging due to multiple confounders. Here, the authors develop a quantitative approach to study CRISPR-transduced patient-derived xenografts, which they use to analyse in vivo
Externí odkaz:
https://doaj.org/article/5fd8470d7bc644e19c6718168d7a7669
Autor:
Tehmina Masud, Charles Soong, Hong Xu, Justina Biele, Saelin Bjornson, Steven McKinney, Samuel Aparicio
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract CX-5461 is a G-quadruplex (G4) ligand currently in trials with initial indications of clinical activity in cancers with defects in homologous recombination repair. To identify more genetic defects that could sensitize tumors to CX-5461, we t
Externí odkaz:
https://doaj.org/article/0c06815b27ef4bb085b1d4ca77a4acee
Autor:
Tyler Funnell, Shinya Tasaki, Arusha Oloumi, Shinsuke Araki, Esther Kong, Damian Yap, Yusuke Nakayama, Christopher S. Hughes, S.-W. Grace Cheng, Hirokazu Tozaki, Misa Iwatani, Satoshi Sasaki, Tomohiro Ohashi, Tohru Miyazaki, Nao Morishita, Daisuke Morishita, Mari Ogasawara-Shimizu, Momoko Ohori, Shoichi Nakao, Masatoshi Karashima, Masaya Sano, Aiko Murai, Toshiyuki Nomura, Noriko Uchiyama, Tomohiro Kawamoto, Ryujiro Hara, Osamu Nakanishi, Karey Shumansky, Jamie Rosner, Adrian Wan, Steven McKinney, Gregg B. Morin, Atsushi Nakanishi, Sohrab Shah, Hiroyoshi Toyoshiba, Samuel Aparicio
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The phosphorylation of serine/arginine-rich proteins by CDC-like kinase is a central regulatory mechanism for RNA splicing reactions. Here, the authors synthesize a novel small molecule CLK inhibitor and map CLK-responsive alternative splicing events
Externí odkaz:
https://doaj.org/article/5aad2179e7e647afa20357dc81dea1bc
Autor:
Hong Xu, Marco Di Antonio, Steven McKinney, Veena Mathew, Brandon Ho, Nigel J. O’Neil, Nancy Dos Santos, Jennifer Silvester, Vivien Wei, Jessica Garcia, Farhia Kabeer, Daniel Lai, Priscilla Soriano, Judit Banáth, Derek S. Chiu, Damian Yap, Daniel D. Le, Frank B. Ye, Anni Zhang, Kelsie Thu, John Soong, Shu-chuan Lin, Angela Hsin Chin Tsai, Tomo Osako, Teresa Algara, Darren N. Saunders, Jason Wong, Jian Xian, Marcel B. Bally, James D. Brenton, Grant W. Brown, Sohrab P. Shah, David Cescon, Tak W. Mak, Carlos Caldas, Peter C. Stirling, Phil Hieter, Shankar Balasubramanian, Samuel Aparicio
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Stabilization of DNA quadruplex structures (G4) is lethal for cells with a compromised DNA repair pathway. Here, the authors show that CX-5461, a small molecule in clinical trials as RNA polymerase inhibitor, has G4-stablization properties and can be
Externí odkaz:
https://doaj.org/article/5b722e62084b4032919682ab16257e1a
Autor:
Tyler Funnell, Allen W Zhang, Diljot Grewal, Steven McKinney, Ali Bashashati, Yi Kan Wang, Sohrab P Shah
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 2, p e1006799 (2019)
Mutation signatures in cancer genomes reflect endogenous and exogenous mutational processes, offering insights into tumour etiology, features for prognostic and biologic stratification and vulnerabilities to be exploited therapeutically. We present a
Externí odkaz:
https://doaj.org/article/ab279b1e35ef453293e1bb2fbda413c6
Autor:
Anita Langerød, Carlos Caldas, Anne-Lise Børresen-Dale, Samuel Aparicio, Vessela N. Kristensen, David A. Quigley, Tomo Osako, Steven McKinney, Oscar M. Rueda, Suet-Feung Chin, Hans Kristian Moen Vollan, Laxmi Silwal-Pandit
PDF file - 29KB, Figure S6. Kaplan-Meier survival curves. A. OS of TP53 mutation status in whole cohort B. BCSS of TP53 mutation status in patients not treated with adjuvant chemotherapy. Numbers at risk are listed below each chart e = no. of all dea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5222b10bb567ef6e23df7490bf8f5226
https://doi.org/10.1158/1078-0432.22448207
https://doi.org/10.1158/1078-0432.22448207
Autor:
Anita Langerød, Carlos Caldas, Anne-Lise Børresen-Dale, Samuel Aparicio, Vessela N. Kristensen, David A. Quigley, Tomo Osako, Steven McKinney, Oscar M. Rueda, Suet-Feung Chin, Hans Kristian Moen Vollan, Laxmi Silwal-Pandit
XLSX file - 94KB, Table S1 TP53 mutation status, TP53 IHC staining and lymphocyte infiltration. Table S2 Univariate Cox regression analysis (BCSS). Table S3 Multivariate Cox regression analysis (BCSS). Table S4 Multivariate Cox regression analysis (O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6233e8587e49b8ada3ad81356de82cd7
https://doi.org/10.1158/1078-0432.22448195.v1
https://doi.org/10.1158/1078-0432.22448195.v1
Autor:
Anita Langerød, Carlos Caldas, Anne-Lise Børresen-Dale, Samuel Aparicio, Vessela N. Kristensen, David A. Quigley, Tomo Osako, Steven McKinney, Oscar M. Rueda, Suet-Feung Chin, Hans Kristian Moen Vollan, Laxmi Silwal-Pandit
PDF file - 40KB, Figure S8. A. Frequency of TP53 mutations and LOH in PAM50 and IC subtypes. B. Kaplan-Meier survival curves showing BCSS of TP53 mutation status in combination with LOH and MDM2 amplification. C. BCSS of TP53 mutation status combined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38761dd400be08e399dd2f84b9b95ccf
https://doi.org/10.1158/1078-0432.22448201.v1
https://doi.org/10.1158/1078-0432.22448201.v1
Autor:
Anita Langerød, Carlos Caldas, Anne-Lise Børresen-Dale, Samuel Aparicio, Vessela N. Kristensen, David A. Quigley, Tomo Osako, Steven McKinney, Oscar M. Rueda, Suet-Feung Chin, Hans Kristian Moen Vollan, Laxmi Silwal-Pandit
PDF file - 22KB, Figure S4. Distribution of TP53 mutations in IC subtypes. A. METABRIC cohort. B. TCGA cohort.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a52fd0bd36fba263fe9c121b961d051
https://doi.org/10.1158/1078-0432.22448213
https://doi.org/10.1158/1078-0432.22448213
Autor:
Anita Langerød, Carlos Caldas, Anne-Lise Børresen-Dale, Samuel Aparicio, Vessela N. Kristensen, David A. Quigley, Tomo Osako, Steven McKinney, Oscar M. Rueda, Suet-Feung Chin, Hans Kristian Moen Vollan, Laxmi Silwal-Pandit
PDF file - 162KB, Figure S5. Boxplot diagram showing APOBEC3B mRNA expression levels as log intensity values in TP53 mutated and wildtype samples stratified by PAM50 subtypes. The bold black line represents the mean APOBEC3B expression value and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039af26bf5df51fe3587e1250cf20ab9
https://doi.org/10.1158/1078-0432.22448210.v1
https://doi.org/10.1158/1078-0432.22448210.v1