Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Steven K. Davidsen"'
Autor:
Patrick A. Marcotte, Jun Guo, Michael R. Michaelides, Steven K. Davidsen, David R. Reuter, Junling Li, Yanping Luo, Lori J. Pease, Chris Tse, Terrance J. Magoc, Ru-Qi Wei, Paul Tapang, Eric F. Johnson, Cherrie K. Donawho, Zehan Chen, Amanda M. Olson, Donald J. Osterling, Daniel H. Albert, Michael L. Curtin, Keith B. Glaser, Jennifer J. Bouska, Mai H. Bui, Robin R. Frey
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 343:617-627
ABT-348 [1-(4-(4-amino-7-(1-(2-hydroxyethyl)-1H-pyrazol-4-yl)thieno[3,2-c]pyridin-3-yl)phenyl)-3-(3-fluorophenyl)urea] is a novel ATP-competitive multitargeted kinase inhibitor with nanomolar potency (IC(50)) for inhibiting binding and cellular autop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ff4def0b6e7aabec77986594da503f
https://doi.org/10.1124/jpet.112.197087
https://doi.org/10.1124/jpet.112.197087
Autor:
Keith B. Glaser, Jasinghe Viraj Janakakumara, Steven K. Davidsen, Senthilnathan Palaniyandi, Chien-Shing Chen, Kian-Ghee Tay, Wee Joo Chng, Shaw-Cheng Liu, Zhigang Xie, Jianbiao Zhou, Lai-Fong Poon, Daniel H. Albert, Chonglei Bi, Hanry Yu
Publikováno v:
Blood. 113:4052-4062
To further investigate potential mechanisms of resistance to FLT3 inhibitors, we developed a resistant cell line by long-term culture of MV4-11 cells with ABT-869, designated as MV4-11-R. Gene profiling reveals up-regulation of FLT3LG (FLT3 ligand) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac654044f5201a09f5fa11fbbaae018
https://doi.org/10.1182/blood-2008-05-156422
https://doi.org/10.1182/blood-2008-05-156422
Autor:
Bryan F. Cox, Steven K. Davidsen, Daniel H. Albert, William T. Noonan, Deborah L. Widomski, Paul Tapang, Gary A. Gintant, Pamela H. Franklin, Ryan M. Fryer, Jason A. Segreti, Patricia N. Banfor, Kelly J. Larson
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 329:928-937
ABT-869 [N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea] is a novel multitargeted inhibitor of the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor tyrosine kinase family members. AB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511ec23ea8a2a42e3086cda5b3ea3409
https://doi.org/10.1124/jpet.108.144816
https://doi.org/10.1124/jpet.108.144816
Autor:
Palaniyandi Senthilnathan, Viraj J. Jasinghe, Chien-Shing Chen, Zhigang Xie, Jianbiao Zhou, Daniel H. Albert, Jiaying Khng, Keith B. Glaser, Steven K. Davidsen, Lai-Fong Poon
Publikováno v:
Journal of Hepatology. 49:985-997
Receptor tyrosine kinase inhibitors (RTKIs) and mTOR inhibitors are potential novel anticancer therapies for HCC. We hypothesized that combination targeted on distinctive signal pathways would provide synergistic therapeutics.ABT-869, a novel RTKI, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded122f6c7df93e6a8fd682dd21990a5
https://doi.org/10.1016/j.jhep.2008.08.010
https://doi.org/10.1016/j.jhep.2008.08.010
Autor:
Lora A. Tucker, George S. Sheppard, Shaun M. McLoughlin, Rick Lesniewski, Joseph L. Meuth, Paul L. Richardson, Steven K. Davidsen, Scott E. Warder, Randy L. Bell, Jieyi Wang, Tamara J. Strelitzer, John C. Rogers, Qian Zhang
Publikováno v:
Journal of Proteome Research. 7:4807-4820
The catalytic activity of methionine aminopeptidase-2 (MetAP2) has been pharmacologically linked to cell growth, angiogenesis, and tumor progression, making this an attractive target for cancer therapy. An assay for monitoring specific protein change
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba03d293aa7547a6dff09a3d20283f2
https://doi.org/10.1021/pr800388p
https://doi.org/10.1021/pr800388p
Autor:
Steve D. Fidanze, Randy L. Bell, Lora A. Tucker, Gary T. Wang, Jieyi Wang, Xiaoming Hu, Julie L. Wilsbacher, Robert D. Hubbard, Nwe Y. Bamaung, Qian Zhang, George S. Sheppard, Steven K. Davidsen
Publikováno v:
Journal of Biological Chemistry. 283:23721-23730
The insulin-like growth factor-1 receptor (IGF-1R) and ErbB family of receptors are receptor tyrosine kinases that play important roles in cancer. Lack of response and resistance to therapies targeting ErbB receptors occur and are often associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bef7595ed92b382b237719639d1f718
https://doi.org/10.1074/jbc.m708360200
https://doi.org/10.1074/jbc.m708360200
Autor:
David R. Reuter, Patrick A. Marcotte, Niru B. Soni, Amanda M. Olson, Jennifer J. Bouska, Yujia Dai, Lori J. Pease, Donald J. Osterling, Kresna Hartandi, Daniel H. Albert, Keith B. Glaser, Stella Z. Doktor, Kent D. Stewart, Steven K. Davidsen, Michael R. Michaelides
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:386-390
Tumor angiogenesis is mediated by KDR and other VEGFR and PDGFR kinases. Their inhibition presents an attractive approach for developing anticancer therapeutics. Here, we report a series of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitarge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1fe6f2e83f5001005ed414b7c94447
https://doi.org/10.1016/j.bmcl.2007.10.018
https://doi.org/10.1016/j.bmcl.2007.10.018
Autor:
Zhigang Xie, Han Jh, Tai Yc, Michael B. Lilly, Lim Yp, Chonglei Bi, Jianbiao Zhou, Keith B. Glaser, Daniel H. Albert, Chien-Shing Chen, Mengfei Pan, Steven K. Davidsen, Loh Sl
Publikováno v:
Leukemia. 22:138-146
Internal tandem duplications (ITDs) of fms-like tyrosine kinase 3 (FLT3) receptor play an important role in the pathogenesis of acute myeloid leukemia (AML) and represent an attractive therapeutic target. ABT-869 has demonstrated potent effects in AM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91be0aee3f398e707768098cfad7e41
https://doi.org/10.1038/sj.leu.2404960
https://doi.org/10.1038/sj.leu.2404960
Autor:
Peter F. Bousquet, Daniel H. Albert, Gary A. Gintant, Patrick A. Marcotte, Gilbert Diaz, George A. Cunha, Ruth L. Martin, Kathryn Houseman, Stevan W. Djuric, Jürgen Dinges, Jennifer J. Bouska, Thomas J. Sowin, Paul Tapang, Charles W. Hutchins, Michael R. Michaelides, Kimba L. Ashworth, Eric F. Johnson, Henry Q. Zhang, Irini Akritopoulou-Zanze, Michelle Nyein, Arnold Lee D, Hu Li, Steven K. Davidsen, Alan F. Gasiecki, Christopher M. Harris, Vijaya Gracias, Zhi Su, Zhiren Xia
Publikováno v:
Journal of Medicinal Chemistry. 50:2011-2029
The synthesis of a novel series of 1,4-dihydroindeno[1,2-c]pyrazoles with acetylene-type side chains is described. Optimization of those compounds as KDR kinase inhibitors identified 8, which displayed an oral activity in an estradiol-induced murine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7224e585fce7d1645dd21a1f5e3e55
https://doi.org/10.1021/jm061223o
https://doi.org/10.1021/jm061223o
Autor:
Melinda Yates, Lori J. Pease, Patrick A. Marcotte, Jennifer J. Bouska, Niru B. Soni, Daniel H. Albert, Robin R. Frey, Steven K. Davidsen, Michael L. Curtin, Keith B. Glaser, Michael R. Michaelides, Peter J. Dandliker, Asma A Ahmed, Paul Rafferty, Kent D. Stewart, Maria D Moskey, Candace Black-Schaefer, Peter F. Bousquet, H. Robin Heyman, George A. Cunha
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1246-1249
A series of substituted thienopyridine ureas was prepared and evaluated for enzymatic and cellular inhibition of KDR kinase activity. Several of these analogs, such as 2, are potent inhibitors of KDR (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0affa478acc38849cf981621ca7094cd
https://doi.org/10.1016/j.bmcl.2006.12.015
https://doi.org/10.1016/j.bmcl.2006.12.015