Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Steven, de Jonghe"'
Autor:
Jean Herman, Els Vanstreels, Dorothée Bardiot, Andrea E Prota, Natacha Gaillard, Ling-Jie Gao, Thomas Vercruysse, Leentje Persoons, Tinne Daems, Mark Waer, Piet Herdewijn, Thierry Louat, Michel O Steinmetz, Steven De Jonghe, Ben Sprangers, Dirk Daelemans
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0307153 (2024)
Microtubule-targeting agents are an important class of anti-cancer drugs; their full potential is however not realized because of significant myelotoxicity and neurotoxicity. We here report 3-nitropyridine analogues as a novel group of microtubule-ta
Externí odkaz:
https://doaj.org/article/6fdecf164cea42cdbd9b349cb2345daf
Autor:
Sirle Saul, Marwah Karim, Luca Ghita, Pei-Tzu Huang, Winston Chiu, Verónica Durán, Chieh-Wen Lo, Sathish Kumar, Nishank Bhalla, Pieter Leyssen, Farhang Alem, Niloufar A. Boghdeh, Do H.N. Tran, Courtney A. Cohen, Jacquelyn A. Brown, Kathleen E. Huie, Courtney Tindle, Mamdouh Sibai, Chengjin Ye, Ahmed Magdy Khalil, Kevin Chiem, Luis Martinez-Sobrido, John M. Dye, Benjamin A. Pinsky, Pradipta Ghosh, Soumita Das, David E. Solow-Cordero, Jing Jin, John P. Wikswo, Dirk Jochmans, Johan Neyts, Steven De Jonghe, Aarthi Narayanan, Shirit Einav
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Targeting host factors exploited by multiple viruses could offer broad-spectrum solutions for pandemic preparedness. Seventeen candidates targeting diverse functions emerged in a screen of 4,413 compounds for SARS-CoV-2 inhibitors. We demonstrated th
Externí odkaz:
https://doaj.org/article/9cc9d935abdc4025aa6c81ab75a6d932
Autor:
Tom Grisez, Nitha Panikkassery Ravi, Mathy Froeyen, Dominique Schols, Luc Van Meervelt, Steven De Jonghe, Wim Dehaen
Publikováno v:
Molecules, Vol 29, Iss 5, p 954 (2024)
Disubstituted isothiazolo[4,3-b]pyridines are known inhibitors of cyclin G-associated kinase. Since 3-substituted-7-aryl-isothiazolo[4,3-b]pyridines remain elusive, a strategy was established to prepare this chemotype, starting from 2,4-dichloro-3-ni
Externí odkaz:
https://doaj.org/article/6adfaa32270c44a1bcf40a26f955d7cb
Autor:
Maria Karelou, Dionysis Kampasis, Amalia D. Kalampaliki, Leentje Persoons, Andreas Krämer, Dominique Schols, Stefan Knapp, Steven De Jonghe, Ioannis K. Kostakis
Publikováno v:
Molecules, Vol 28, Iss 23, p 7912 (2023)
Sixteen new 2-substituted quinazolines were synthesized using a straightforward methodology starting from 2-methoxybezoic acid or 3-methoxy-2-naphthoic acid. The anti-proliferative activity of the target compounds was evaluated against nine cancer ce
Externí odkaz:
https://doaj.org/article/c1e34cc6d968471da7bd856cf8b08908
Autor:
Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen, Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon, Pieter Leyssen
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-11 (2022)
Measurement(s) Cytopathic Effect Technology Type(s) confocal fluorescence microscopy Factor Type(s) Cellular toxicity Sample Characteristic - Organism Chlorocebus sabaeus Sample Characteristic - Environment continuant Sample Characteristic - Location
Externí odkaz:
https://doaj.org/article/d090bc5600084cffb8b7e56ad1250b1a
Autor:
Rana Abdelnabi, Caroline S. Foo, Dirk Jochmans, Laura Vangeel, Steven De Jonghe, Patrick Augustijns, Raf Mols, Birgit Weynand, Thanaporn Wattanakul, Richard M. Hoglund, Joel Tarning, Charles E. Mowbray, Peter Sjö, Fanny Escudié, Ivan Scandale, Eric Chatelain, Johan Neyts
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
There is an urgent need for anti-virals targeting SARS-CoV-2. One of the most promising viral targets is the main protease of SARS-CoV-2, which is essential for viral replication and has no human analogue. Here, Abdelnabi et al. show that one of the
Externí odkaz:
https://doaj.org/article/8a988a1b7f644a20bb1a138315f14db0
Autor:
Dirk Jochmans, Cheng Liu, Kim Donckers, Antitsa Stoycheva, Sandro Boland, Sarah K. Stevens, Chloe De Vita, Bert Vanmechelen, Piet Maes, Bettina Trüeb, Nadine Ebert, Volker Thiel, Steven De Jonghe, Laura Vangeel, Dorothée Bardiot, Andreas Jekle, Lawrence M. Blatt, Leonid Beigelman, Julian A. Symons, Pierre Raboisson, Patrick Chaltin, Arnaud Marchand, Johan Neyts, Jerome Deval, Koen Vandyck
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT The SARS-CoV-2 main protease (3CLpro) has an indispensable role in the viral life cycle and is a therapeutic target for the treatment of COVID-19. The potential of 3CLpro-inhibitors to select for drug-resistant variants needs to be establish
Externí odkaz:
https://doaj.org/article/68b3f8dcc3b24cffa15d8cab99c36119
Autor:
Abhimanyu K. Singh, Sergio E. Martinez, Weijie Gu, Hoai Nguyen, Dominique Schols, Piet Herdewijn, Steven De Jonghe, Kalyan Das
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Here the authors observe a transient P-pocket created when HIV reverse transcriptase slides over DNA substrate, identify fragments targeting this pocket, and develop a cryo-EM platform for lead optimization.
Externí odkaz:
https://doaj.org/article/9dfb249ea4bc4f7bbae81ab4c18df594
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Remdesivir was the first antiviral drug to be approved for the treatment of severe COVID-19; followed by molnupiravir (another prodrug of a nucleoside analogue) and the protease inhibitor nirmatrelvir. Combination of antiviral drugs may result in imp
Externí odkaz:
https://doaj.org/article/32a022de172346eca43b6d44f9b82a39
Autor:
Belén Martinez-Gualda, Mirthe Graus, Anita Camps, Emiel Vanhulle, Sirle Saul, Siavash Azari, Do Hoang Nhu Tran, Laura Vangeel, Winston Chiu, Johan Neyts, Dominique Schols, Shirit Einav, Kurt Vermeire, Steven De Jonghe
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
RNA viral infections, including those caused by respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and Venezuelan Equine encephalitis virus (VEEV), pose a major global health challenge. Here, we report th
Externí odkaz:
https://doaj.org/article/b71621893a6241afbd7e65cfc4b5b2f3