Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Steven, Zhang"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 6, Pp 731-744 (2022)
Abstract Mobocertinib is an oral tyrosine kinase inhibitor approved for treatment of patients with locally advanced or metastatic non‐small cell lung cancer (mNSCLC) with epidermal growth factor receptor gene (EGFR) exon 20 insertion mutations whos
Externí odkaz:
https://doaj.org/article/548aeda3c00242be84adc1b4dd06e87f
Publikováno v:
Energy and AI, Vol 8, Iss , Pp 100150- (2022)
Local energy markets are emerging as a tool for coordinating generation, storage, and consumption of energy from distributed resources. In combination with automation, they promise to provide an effective energy management framework that is fair and
Externí odkaz:
https://doaj.org/article/408478d9110d4224878f12ff4b6c51be
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0260565 (2022)
TLR7 and TLR8 are key members of the Toll-like receptor family, playing crucial roles in the signaling pathways of innate immunity, and thus become attractive therapeutic targets of many diseases including infections and cancer. Although TLR7 and TLR
Externí odkaz:
https://doaj.org/article/19d9d3b1deb0470f9f6ce7c3de066a13
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences. 25:402-417
Purpose: To describe patient characteristics, treatment patterns, and the burden of illness among adult migraine patients in Canada prescribed migraine prophylactics. Little is known about the relative persistence of treatments in the real-world sett
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69fb1fa02d3f91fb2f72c105c1e5be24
https://doi.org/10.18433/jpps33158
https://doi.org/10.18433/jpps33158
An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus
Autor:
Albertas Navickas, Hosseinali Asgharian, Juliane Winkler, Lisa Fish, Kristle Garcia, Daniel Markett, Martin Dodel, Bruce Culbertson, Sohit Miglani, Tanvi Joshi, Keyi Yin, Phi Nguyen, Steven Zhang, Nicholas Stevers, Hun-Way Hwang, Faraz Mardakheh, Andrei Goga, Hani Goodarzi
Publikováno v:
Nature cell biology, vol 25, iss 6
Cancer cells often co-opt post-transcriptional regulatory mechanisms to achieve pathologic expression of gene networks that drive metastasis. Translational control is a major regulatory hub in oncogenesis; however, its effects on cancer progression r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba97ac6204b87cfd1b8c286a7d951fc
https://escholarship.org/uc/item/0rw7759t
https://escholarship.org/uc/item/0rw7759t
Autor:
Pasi A. Jänne, Shuanglian Li, Shu Jin, Veronica Bunn, Jianchang Lin, Steven Zhang, Sylvie Vincent, Danny Nguyen, Ryan D. Gentzler, Tarek Mekhail, Howard L. West, Viola W. Zhu, Lyudmila Bazhenova, Shirish M. Gadgeel, Jyoti D. Patel, Anne S. Tsao, Daniel B. Costa, Zofia Piotrowska, Alexander I. Spira, D. Ross Camidge, Joel W. Neal, Gregory J. Riely
Mobocertinib, an oral epidermal growth factor receptor (EGFR) inhibitor targeting EGFR gene mutations, including exon 20 insertions (EGFRex20ins), in non–small cell lung cancer, was evaluated in a phase I/II dose-escalation/expansion trial (Clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d2bc425d2ed40de9a8898b8fdcd6d6
https://doi.org/10.1158/2159-8290.c.6549404
https://doi.org/10.1158/2159-8290.c.6549404
Autor:
Shin-Haw Lee, Andrew Toye Ojo, Matthew Halat, Nataly Bleibdrey, Steven Zhang, Rob Chalmers, Dan Zimskind
Publikováno v:
International Journal of Health Economics and Management.
Background Suspension of cancer screening and treatment programs were instituted to preserve medical resources and protect vulnerable populations. This research aims to investigate the implications of COVID-19 on cancer management and clinical outcom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89988ad4051d4902f38300d6949eadb7
https://doi.org/10.1007/s10754-023-09342-3
https://doi.org/10.1007/s10754-023-09342-3
Autor:
Islam Younis, Ashish Sharma, Luna Musib, Steven Zhang, Jitendra Kanodia, Vaishali Sahasrabudhe
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:946-958
Chronic kidney disease (CKD) is an important health issue that affects ~ 9.1% of the world adult population. Serum creatinine is the most commonly used biomarker for assessing kidney function and is utilized in different equations for estimating crea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6ab52d7854ca470a917a3b742bf49c
https://doi.org/10.1002/cpt.2489
https://doi.org/10.1002/cpt.2489
Autor:
Stephen C. Pflugfelder, Desiree V Owen, Edward J. Holland, Christopher E. Starr, Kim Brazzell, Steven Zhang, Reza Dana
Publikováno v:
The Ocular Surface. 22:51-59
Purpose Characteristics of periodic flares of dry eye disease (DED) are not well understood. We conducted a rapid evidence assessment to identify evidence for and characteristics of DED flares. Methods Literature searches were performed in Embase® v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc300749b4d08a26845345b1180c2064
https://doi.org/10.1016/j.jtos.2021.07.001
https://doi.org/10.1016/j.jtos.2021.07.001
Autor:
Zhongling Feng, S. Jin, Jianchang Lin, Steven Zhang, C. Griffin, Karthik Venkatakrishnan, Neeraj Gupta
Publikováno v:
Clinical Pharmacology in Drug Development
Mobocertinib (TAK‐788) is an investigational oral tyrosine kinase inhibitor targeting epidermal growth factor receptor and human epidermal growth factor 2. A phase 1 open‐label, 2‐period, fixed‐sequence, 2‐part study ({"type":"clinical-tria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b184b96dbc310c0bfb431d7ab57ed4c4
https://doi.org/10.1002/cpdd.967
https://doi.org/10.1002/cpdd.967