High-resolution structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition

Autor: Sandip Basak, Arvind Kumar, Steven Ramsey, Eric Gibbs, Abhijeet Kapoor, Marta Filizola, Sudha Chakrapani

Publikováno v: eLife, Vol 9 (2020)

Serotonin receptors (5-HT3AR) play a crucial role in regulating gut movement, and are the principal target of setrons, a class of high-affinity competitive antagonists, used in the management of nausea and vomiting associated with radiation and chemo

Externí odkaz: https://doaj.org/article/ff96e1ad8c044f679da8e43683623a1d

Inclusion of enclosed hydration effects in the binding free energy estimation of dopamine D3 receptor complexes.

Autor: Rajat Kumar Pal, Satishkumar Gadhiya, Steven Ramsey, Pierpaolo Cordone, Lauren Wickstrom, Wayne W Harding, Tom Kurtzman, Emilio Gallicchio

Publikováno v: PLoS ONE, Vol 14, Iss 9, p e0222902 (2019)

Confined hydration and conformational flexibility are some of the challenges encountered for the rational design of selective antagonists of G-protein coupled receptors. We present a set of C3-substituted (-)-stepholidine derivatives as potent binder

Externí odkaz: https://doaj.org/article/d6a2f7dc5fbd4c8b88743949e59a4d94

Developing Large-Scale Research in Response to an Oil Spill Disaster: a Case Study

Autor: Kaitlyn B. Gam, Richard K. Kwok, Dale P. Sandler, Aaron Blair, Aubrey Miller, Lawrence S. Engel, Matthew D. Curry, Steven Ramsey

Publikováno v: Curr Environ Health Rep

Research conducted in the wake of a disaster can provide information to help mitigate health consequences, support future recovery efforts, and improve resilience. However, a number of barriers have prevented time-sensitive research responses followi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4fa974e796a83d377577d91d7fb711
https://doi.org/10.1007/s40572-019-00241-9

Developing an Environmental Health Sciences COVID-19 Research Agenda: Results from the NIEHS Disaster Research Response (DR2) Work Group’s Modified Delphi Method

Autor: Sara Webb, Megan Couture, Kimberley Shoaf, April Bennett, Steven Ramsey, Aubrey Miller, Marilyn Howarth, Nicole A. Errett, Richard Rosselli

Publikováno v: International Journal of Environmental Research and Public Health
Volume 17
Issue 18
International Journal of Environmental Research and Public Health, Vol 17, Iss 6842, p 6842 (2020)

Leveraging the community of practice recently established through the U.S. National Institute of Environmental Health Sciences (NIEHS) Disaster Research Response (DR2) working group, we used a modified Delphi method to identify and prioritize environ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8b06c356498ea224de659244944b1a

High-resolution Structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition

Autor: Eric Gibbs, Arvind Kumar, Sandip Basak, Abhijeet Kapoor, Sudha Chakrapani, Marta Filizola, Steven Ramsey

Publikováno v: eLife, Vol 9 (2020)

Serotonin is perhaps best known as a chemical messenger in the brain, where it regulates mood, appetite and sleep. But as a hormone, serotonin works in other parts of the body too. Serotonin is predominantly made in the gut, where it binds receptor p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88294fcb5332c33ac97ad0ea4a59cfb