Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Steven, Novick"'
Autor:
Tyler Brady, Tianhui Zhang, Kevin M. Tuffy, Nantaporn Haskins, Qun Du, Jia Lin, Gilad Kaplan, Steven Novick, Tiffany L. Roe, Kuishu Ren, Kim Rosenthal, Patrick M. McTamney, Michael E. Abram, Katie Streicher, Elizabeth J. Kelly
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT AZD7442, a combination of two long-acting monoclonal antibodies (tixagevimab [AZD8895] and cilgavimab [AZD1061]), has been authorized for the prevention and treatment of coronavirus disease 2019 (COVID-19). The rapid emergence of severe acut
Externí odkaz:
https://doaj.org/article/98d4176648a242c59e666ffdfbd7fce6
Autor:
Ventzislava A. Hristova, Alastair Watson, Raghothama Chaerkady, Matthew S. Glover, Jodie Ackland, Bastian Angerman, Graham Belfield, Maria G. Belvisi, Hannah Burke, Doriana Cellura, Howard W. Clark, Damla Etal, Anna Freeman, Ashley I. Heinson, Sonja Hess, Michael Hühn, Emily Hall, Alex Mackay, Jens Madsen, Christopher McCrae, Daniel Muthas, Steven Novick, Kristoffer Ostridge, Lisa Öberg, Adam Platt, Anthony D. Postle, C. Mirella Spalluto, Outi Vaarala, Junmin Wang, Karl J. Staples, Tom M.A. Wilkinson, on behalf of the MICA II Study group
Publikováno v:
ERJ Open Research, Vol 9, Iss 3 (2022)
Rationale Pulmonary surfactant is vital for lung homeostasis as it reduces surface tension to prevent alveolar collapse and provides essential immune-regulatory and antipathogenic functions. Previous studies demonstrated dysregulation of some individ
Externí odkaz:
https://doaj.org/article/d0133b7993c74d2bbea08bf595e4130e
Autor:
Jill Walker, Jane Osbourn, Arnaud C. Tiberghien, Nazzareno Dimasi, Dipesha P. Shah, Terrence O'Day, Steven Novick, William O. Iverson, Yuling Wu, Bo Zheng, Shannon Breen, Subramanya Karanth, Ryan Fleming, Agnieszka Sadowska, Christopher Ward, Vanessa Muniz-Medina, Suneetha B. Thomas, Elaine M. Hurt, Michael G. Overstreet, Saravanan Rajan, Ruoyan Chen
Multiple myeloma is a hematologic cancer that disrupts normal bone marrow function and has multiple lines of therapeutic options, but is incurable as patients ultimately relapse. We developed a novel antibody–drug conjugate (ADC) targeting CS-1, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063a7b8839eda8429b31260763a0368a
https://doi.org/10.1158/1535-7163.c.6542664
https://doi.org/10.1158/1535-7163.c.6542664
Autor:
Jill Walker, Jane Osbourn, Arnaud C. Tiberghien, Nazzareno Dimasi, Dipesha P. Shah, Terrence O'Day, Steven Novick, William O. Iverson, Yuling Wu, Bo Zheng, Shannon Breen, Subramanya Karanth, Ryan Fleming, Agnieszka Sadowska, Christopher Ward, Vanessa Muniz-Medina, Suneetha B. Thomas, Elaine M. Hurt, Michael G. Overstreet, Saravanan Rajan, Ruoyan Chen
Supplementary Materials and Methods, Supplementary Table S1. Sources of cell lines and cell growth media; Supplemental Table S2. Sources of antibodies for flow cytometry; Supplementary Table S3. CS-1 ADC Characteristics, Supplemental Table S4. Pharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62318dd34971780d373a1e55ed154426
https://doi.org/10.1158/1535-7163.22520520.v1
https://doi.org/10.1158/1535-7163.22520520.v1
Autor:
Puja Sapra, Nadia Luheshi, Philip W. Howard, David A. Tice, Anna D. Staniszewska, Mark R. Albertella, Elisabetta Leo, Yann Wallez, Frances Anne Tosto, Darrin Sabol, R. James Christie, Nazzareno Dimasi, Jixin Wang, Steven Novick, Noel Monks, Judith Anderton, Jon Chesebrough, Jiaqi Yuan, Anton I. Rosenbaum, Yue Huang, Arthur Lewis, Michael Davies, Kathryn Ball, Mary McFarlane, Balakumar Vijayakrishnan, Ian Hutchinson, Thais Cailleau, Luke Masterson, Niall J. Dickinson, Zachary A. Cooper, Philipp Wortmann, Krista Kinneer
Supplementary Figure S1. Analytical characterization of INT016-ADCs; Supplementary Figure S2. Validation of B7-H4 antibodies for use in IHC; Supplementary Figure S3. Relationship between B7-H4 expression level and heterogeneity in the studied human t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0600301b9082af559c2fa9c3e42833d8
https://doi.org/10.1158/1078-0432.22490063.v1
https://doi.org/10.1158/1078-0432.22490063.v1
Autor:
Puja Sapra, Nadia Luheshi, Philip W. Howard, David A. Tice, Anna D. Staniszewska, Mark R. Albertella, Elisabetta Leo, Yann Wallez, Frances Anne Tosto, Darrin Sabol, R. James Christie, Nazzareno Dimasi, Jixin Wang, Steven Novick, Noel Monks, Judith Anderton, Jon Chesebrough, Jiaqi Yuan, Anton I. Rosenbaum, Yue Huang, Arthur Lewis, Michael Davies, Kathryn Ball, Mary McFarlane, Balakumar Vijayakrishnan, Ian Hutchinson, Thais Cailleau, Luke Masterson, Niall J. Dickinson, Zachary A. Cooper, Philipp Wortmann, Krista Kinneer
Surface plasmon resonance; In vitro cytotoxicity assays; In vitro proliferation assays; Internalization assays; Subcellular localization microscopy; Immunoblotting; Statistical analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58213ceddc604034835e98180a6978da
https://doi.org/10.1158/1078-0432.22490054
https://doi.org/10.1158/1078-0432.22490054
Autor:
Puja Sapra, Nadia Luheshi, Philip W. Howard, David A. Tice, Anna D. Staniszewska, Mark R. Albertella, Elisabetta Leo, Yann Wallez, Frances Anne Tosto, Darrin Sabol, R. James Christie, Nazzareno Dimasi, Jixin Wang, Steven Novick, Noel Monks, Judith Anderton, Jon Chesebrough, Jiaqi Yuan, Anton I. Rosenbaum, Yue Huang, Arthur Lewis, Michael Davies, Kathryn Ball, Mary McFarlane, Balakumar Vijayakrishnan, Ian Hutchinson, Thais Cailleau, Luke Masterson, Niall J. Dickinson, Zachary A. Cooper, Philipp Wortmann, Krista Kinneer
Supplementary Table S1. Primary antibodies used for immunoblotting; Supplementary Table S2. Characterization of ADCs evaluated in this study; Supplementary Table S3. B7-H4 expression in human normal tissue; Supplementary Table S4. Binding affinity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca0fd579622b6cd057eabe5480be78a
https://doi.org/10.1158/1078-0432.22490048.v1
https://doi.org/10.1158/1078-0432.22490048.v1
Autor:
Puja Sapra, Nadia Luheshi, Philip W. Howard, David A. Tice, Anna D. Staniszewska, Mark R. Albertella, Elisabetta Leo, Yann Wallez, Frances Anne Tosto, Darrin Sabol, R. James Christie, Nazzareno Dimasi, Jixin Wang, Steven Novick, Noel Monks, Judith Anderton, Jon Chesebrough, Jiaqi Yuan, Anton I. Rosenbaum, Yue Huang, Arthur Lewis, Michael Davies, Kathryn Ball, Mary McFarlane, Balakumar Vijayakrishnan, Ian Hutchinson, Thais Cailleau, Luke Masterson, Niall J. Dickinson, Zachary A. Cooper, Philipp Wortmann, Krista Kinneer
Purpose:We evaluated the activity of AZD8205, a B7-H4–directed antibody–drug conjugate (ADC) bearing a novel topoisomerase I inhibitor (TOP1i) payload, alone and in combination with the PARP1-selective inhibitor AZD5305, in preclinical models.Exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d87fea82a590d54f5004536e9439e672
https://doi.org/10.1158/1078-0432.c.6533087
https://doi.org/10.1158/1078-0432.c.6533087
Autor:
Vancheswaran Gopalakrishnan, Elizabeth Ashley Dozier, Matthew S. Glover, Steven Novick, Michael Ford, Christopher Morehouse, Paul Warrener, Carolina Caceres, Sonja Hess, Bret R. Sellman, Taylor S. Cohen
Publikováno v:
Microorganisms, Vol 9, Iss 7, p 1399 (2021)
The gut microbiota has emerged as a key mediator of human physiology, and germ-free mice have been essential in demonstrating a role for the microbiome in disease. Preclinical models using conventional mice offer the advantage of working with a matur
Externí odkaz:
https://doaj.org/article/767e179a4c5a4c099e81d984583ea391
Autor:
Paul Faya, Steven Novick, John W. Seaman, John J. Peterson, Tony Pourmohamad, Dwaine Banton, Yanbing Zheng
Publikováno v:
Statistics in Biopharmaceutical Research. 15:225-233