Výsledky vyhledávání - "Steven, Haesendonckx"

Akademický článek

Ivermectin as an adjuvant to anti-epileptic treatment in persons with onchocerciasis-associated epilepsy: A randomized proof-of-concept clinical trial.

Autor: Michel Mandro, Joseph Nelson Siewe Fodjo, Deby Mukendi, Alfred Dusabimana, Sonia Menon, Steven Haesendonckx, Richard Lokonda, Swabra Nakato, Francoise Nyisi, Germain Abhafule, Deogratias Wonya'Rossi, Jean Marie Jakwong, Patrick Suykerbuyk, Jacques Meganck, An Hotterbeekx, Robert Colebunders

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007966 (2020)

INTRODUCTION:Recent findings from onchocerciasis-endemic foci uphold that increasing ivermectin coverage reduces the epilepsy incidence, and anecdotal evidence suggests seizure frequency reduction in persons with onchocerciasis-associated epilepsy, w

Externí odkaz: https://doaj.org/article/577599405307437ea164259e56940717

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Akademický článek

Single versus Multiple Dose Ivermectin Regimen in Onchocerciasis-Infected Persons with Epilepsy Treated with Phenobarbital: A Randomized Clinical Trial in the Democratic Republic of Congo

Autor: Michel Mandro, Joseph Nelson Siewe Fodjo, Alfred Dusabimana, Deby Mukendi, Steven Haesendonckx, Richard Lokonda, Swabra Nakato, Francoise Nyisi, Germain Abhafule, D Wonya’rossi, An Hotterbeekx, Steven Abrams, Robert Colebunders

Publikováno v: Pathogens, Vol 9, Iss 3, p 205 (2020)

Background: There is anecdotal evidence that ivermectin may decrease seizure frequency in Onchocerca volvulus-infected persons with epilepsy (PWE). Methods: In October 2017, a 12-month clinical trial was initiated in rural Democratic Republic of Cong

Externí odkaz: https://doaj.org/article/c9aafd4168bb4686866bb4d61bded83e

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Chemical Genetics of AGC-kinases Reveals Shared Targets of Ypk1, Protein Kinase A and Sch9

Autor: Markus Müller, Nicolas Winssinger, M. P. Perepelkina, Robbie Loewith, Ruedi Aebersold, Stefania Vaga, Marina Berti, Michael Plank, Jacques Saarbach, Steven Haesendonckx, Xiaoming Zou

Publikováno v: Molecular and Cellular Proteomics, Vol. 19, No 4 (2020) pp. 655-671
Molecular & cellular proteomics, vol. 19, no. 4, pp. 655-671
Molecular & Cellular Proteomics : MCP
Molecular & Cellular Proteomics

Analog-sensitive inhibition was used to define phospho-sites regulated by Sch9, PKA and Ypk1. A considerable number of sites affected by Ypk1 inhibition fell into RRxS/T-contexts and overlapped with PKA sites. Neutral trehalase is activated through p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03bb06a441e57b8a56828014eed1b0a
https://doi.org/10.1074/mcp.ra120.001955

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The Hospital Recovery Scale: A clinically useful endpoint in patients hospitalized with influenza

Autor: Wilbert, van Duijnhoven, Ilse, Van Dromme, Steven, Haesendonckx, James, Witek, Lorant, Leopold

Publikováno v: Contemporary Clinical Trials. 123:106952

Currently, no single best primary endpoint exists for measuring the efficacy of treatments in seriously ill patients with respiratory infections, such as influenza, who require hospitalization. The Hospital Recovery Scale is an ordinal endpoint used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f98deaa25a7e57b5c86b451671a7bc
https://doi.org/10.1016/j.cct.2022.106952

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Single Versus Multiple Dose Ivermectin Regimen in Onchocerciasis-infected Persons with Epilepsy Treated with Phenobarbital: A Randomized Clinical Trial in the Democratic Republic of Congo

Autor: Swabra Nakato, Germain Abhafule, Robert Colebunders, Joseph Nelson Siewe Fodjo, Deogratias Wonya’Rossi, Richard Lokonda, An Hotterbeekx, Steven Haesendonckx, Steven Abrams, Alfred Dusabimana, Francoise Nyisi, Michel Mandro, Deby Mukendi

Publikováno v: Pathogens
Volume 9
Issue 3
Pathogens, Vol 9, Iss 3, p 205 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5440daa10d957dad0741a395932fdc6

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Ivermectin as an adjuvant to anti-epileptic treatment in persons with onchocerciasis-associated epilepsy: A randomized proof-of-concept clinical trial

Autor: Joseph Nelson Siewe Fodjo, Swabra Nakato, Germain Abhafule, Deogratias Wonya’Rossi, Robert Colebunders, Sonia Menon, An Hotterbeekx, Francoise Nyisi, Michel Mandro, Richard Lokonda, Jean Marie Jakwong, Deby Mukendi, Steven Haesendonckx, Alfred Dusabimana, Patrick Suykerbuyk, Jacques Meganck

Publikováno v: PLoS Neglected Tropical Diseases
PLoS neglected tropical diseases
PLOS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007966 (2020)

Introduction Recent findings from onchocerciasis-endemic foci uphold that increasing ivermectin coverage reduces the epilepsy incidence, and anecdotal evidence suggests seizure frequency reduction in persons with onchocerciasis-associated epilepsy, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f34fa76ad29a425f2af8e64bf7da61
https://doi.org/10.1371/journal.pntd.0007966

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From transporter to transceptor: Signaling from transporters provokes re-evaluation of complex trafficking and regulatory controls

Autor: Griet Van Zeebroeck, Johan Kriel, Marta Rubio-Texeira, Johan M. Thevelein, Steven Haesendonckx

Publikováno v: BioEssays. 33:870-879

When cells are starved of their substrate, many nutrient transporters are induced. These undergo rapid endocytosis and redirection of their intracellular trafficking when their substrate becomes available again. The discovery that some of these trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08e13ddd58304318011a3e14530b1ed3
https://doi.org/10.1002/bies.201100100

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The activation loop of PKA catalytic isoforms is differentially phosphorylated by Pkh protein kinases in Saccharomyces cerevisiae

Autor: Johan M. Thevelein, Paula Portela, Karin Voordeckers, Silvia Margarita Moreno, Steven Haesendonckx, Vanesa Romina Tudisca

Publikováno v: The Biochemical journal. 448(3)

PDK1 (phosphoinositide-dependent protein kinase 1) phosphorylates and activates PKA (cAMP-dependent protein kinase) in vitro. Docking of the HM (hydrophobic motif) in the C-terminal tail of the PKA catalytic subunits on to the PIF (PDK1-interacting f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed98650ce846f200c064dea2606ad438
https://pubmed.ncbi.nlm.nih.gov/22957732

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Yeast 3-phosphoinositide-dependent protein kinase-1 (PDK1) orthologs Pkh1-3 differentially regulate phosphorylation of protein kinase A (PKA) and the protein kinase B (PKB)/S6K ortholog Sch9

Autor: Matthias Versele, Karin Voordeckers, Steven Haesendonckx, Wendy Louwet, Marlies Kimpe, Johan M. Thevelein

Publikováno v: The Journal of biological chemistry. 286(25)

Pkh1, -2, and -3 are the yeast orthologs of mammalian 3-phosphoinositide-dependent protein kinase-1 (PDK1). Although essential for viability, their functioning remains poorly understood. Sch9, the yeast protein kinase B and/or S6K ortholog, has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb755fd93392a74de3d17e47f6e377d
https://pubmed.ncbi.nlm.nih.gov/21531713

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Novel mechanisms in nutrient activation of the yeast protein kinase A pathway

Autor: Peter Verhaert, Johan Kriel, Griet Van Zeebroeck, Matthias Versele, Beatriz M. Bonini, Karin Voordeckers, Johan M. Thevelein, Wim Schepers, Yulia Popova, Marta Rubio-Texeira, Dries Castermans, Patrick Vandormael, Palvannan Thayumanavan, Wendy Louwet, Steven Haesendonckx

Publikováno v: Acta microbiologica et immunologica Hungarica. 55(2)

In yeast the Protein Kinase A (PKA) pathway can be activated by a variety of nutrients. Fermentable sugars, like glucose and sucrose, trigger a spike in the cAMP level, followed by activation of PKA and phosphorylation of target proteins causing a.o.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f3aeb033d2c638a74da802c4d500b6
https://pubmed.ncbi.nlm.nih.gov/18595314

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