Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Steven, Govek"'
Autor:
Theodore M, Kamenecka, Céline, Bonnefous, Steven, Govek, Jean-Michel, Vernier, John, Hutchinson, Janice, Chung, Grace, Reyes-Manalo, Jeffery J, Anderson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4350-4353
Modulation of the metabotropic glutamate subtype 5 (mGlu5) receptor may be useful in the treatment of a variety of central nervous system disorders. Herein, we report on the discovery, synthesis, and biological evaluation of dipyridyl amines as small
Autor:
Beatrice Darimont, Steven Govek, James Joseph, Katherine Grillot, Eric Bischoff, Anna Aparicio, Celine Bonnefous, Karensa Douglas, Jackline Julien, Mehmet Kahraman, Joshua Kaufman, Andiliy Lai, Kyoung-Jin Lee, Nhin Lu, Johnny Nagasawa, Rene Prudente, Jing Qian, John Sensintaffar, Gang Shao, Richard Heyman, Peter Rix, Nicholas Smith, Jeffrey Hager
Publikováno v:
Molecular Cancer Therapeutics. 10:A133-A133
60–75% of all breast cancers express the estrogen receptor (ER) and thus are treated with anti-hormonal therapies that directly block ER function (e.g. Tamoxifen) or hormone synthesis (Aromatase Inhibitors). While these therapies are initially effe