Zobrazeno 1 - 10
of 304
pro vyhledávání: '"Steven, Brem"'
Autor:
Iulia Tapescu, Peter J. Madsen, Pedro R. Lowenstein, Maria G. Castro, Stephen J. Bagley, Yi Fan, Steven Brem
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Originally devised for cancer control, mRNA vaccines have risen to the forefront of medicine as effective instruments for control of infectious disease, notably their pivotal role in combating the COVID-19 pandemic. This review focuses on fundamental
Externí odkaz:
https://doaj.org/article/0e9534d7859743ec97b686ecc2e43474
Autor:
Jun Guo, Anahita Fathi Kazerooni, Erik Toorens, Hamed Akbari, Fanyang Yu, Chiharu Sako, Elizabeth Mamourian, Russell T. Shinohara, Constantinos Koumenis, Stephen J. Bagley, Jennifer J. D. Morrissette, Zev A. Binder, Steven Brem, Suyash Mohan, Robert A. Lustig, Donald M. O’Rourke, Tapan Ganguly, Spyridon Bakas, MacLean P. Nasrallah, Christos Davatzikos
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Glioblastoma is a highly heterogeneous disease, with variations observed at both phenotypical and molecular levels. Personalized therapies would be facilitated by non-invasive in vivo approaches for characterizing this heterogeneity. In this
Externí odkaz:
https://doaj.org/article/f5997dcf88784ed0a9eb262aa340f854
Autor:
Youtao Lu, Jaehee Lee, Jifen Li, Srinivasa Rao Allu, Jinhui Wang, HyunBum Kim, Kevin L. Bullaughey, Stephen A. Fisher, C. Erik Nordgren, Jean G. Rosario, Stewart A. Anderson, Alexandra V. Ulyanova, Steven Brem, H. Isaac Chen, John A. Wolf, M. Sean Grady, Sergei A. Vinogradov, Junhyong Kim, James Eberwine
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Genomic DNA (gDNA) undergoes structural interconversion between single- and double-stranded states during transcription, DNA repair and replication, which is critical for cellular homeostasis. We describe “CHEX-seq” which identifies the
Externí odkaz:
https://doaj.org/article/2d577bcc2fbc42bdb820b2ed40c2f17f
Autor:
Zahra Riahi Samani, Drew Parker, Hamed Akbari, Ronald L. Wolf, Steven Brem, Spyridon Bakas, Ragini Verma
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract In malignant primary brain tumors, cancer cells infiltrate into the peritumoral brain structures which results in inevitable recurrence. Quantitative assessment of infiltrative heterogeneity in the peritumoral region, the area where biopsy o
Externí odkaz:
https://doaj.org/article/5bafe6c45c7b4478b8e9ef27235195ca
Autor:
Spyridon Bakas, Chiharu Sako, Hamed Akbari, Michel Bilello, Aristeidis Sotiras, Gaurav Shukla, Jeffrey D. Rudie, Natali Flores Santamaría, Anahita Fathi Kazerooni, Sarthak Pati, Saima Rathore, Elizabeth Mamourian, Sung Min Ha, William Parker, Jimit Doshi, Ujjwal Baid, Mark Bergman, Zev A. Binder, Ragini Verma, Robert A. Lustig, Arati S. Desai, Stephen J. Bagley, Zissimos Mourelatos, Jennifer Morrissette, Christopher D. Watt, Steven Brem, Ronald L. Wolf, Elias R. Melhem, MacLean P. Nasrallah, Suyash Mohan, Donald M. O’Rourke, Christos Davatzikos
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-12 (2022)
Measurement(s) Magnetic Resonance Imaging Technology Type(s) Magnetic Resonance Imaging of the Brain with and without Contrast Sample Characteristic - Organism Homo sapiens Sample Characteristic - Environment brain Sample Characteristic - Location Un
Externí odkaz:
https://doaj.org/article/5d5b415e3a86419991ae9fdec07415bc
Autor:
Anahita Fathi Kazerooni, Sanjay Saxena, Erik Toorens, Danni Tu, Vishnu Bashyam, Hamed Akbari, Elizabeth Mamourian, Chiharu Sako, Costas Koumenis, Ioannis Verginadis, Ragini Verma, Russell T. Shinohara, Arati S. Desai, Robert A. Lustig, Steven Brem, Suyash Mohan, Stephen J. Bagley, Tapan Ganguly, Donald M. O’Rourke, Spyridon Bakas, MacLean P. Nasrallah, Christos Davatzikos
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Multi-omic data, i.e., clinical measures, radiomic, and genetic data, capture multi-faceted tumor characteristics, contributing to a comprehensive patient risk assessment. Here, we investigate the additive value and independent reproducibili
Externí odkaz:
https://doaj.org/article/2e0a631fb2f84bd8ab1d9f8f31d56f26
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Tumor types are classically distinguished based on biopsies of the tumor itself, as well as a radiological interpretation using diverse MRI modalities. In the current study, the overarching goal is to demonstrate that primary (glioblastomas)
Externí odkaz:
https://doaj.org/article/1139ecc47432450a89617a5380bdfd60
Autor:
Hamed Akbari, Anahita Fathi Kazerooni, Jeffrey B. Ware, Elizabeth Mamourian, Hannah Anderson, Samantha Guiry, Chiharu Sako, Catalina Raymond, Jingwen Yao, Steven Brem, Donald M. O’Rourke, Arati S. Desai, Stephen J. Bagley, Benjamin M. Ellingson, Christos Davatzikos, Ali Nabavizadeh
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Glioblastoma (GBM) has high metabolic demands, which can lead to acidification of the tumor microenvironment. We hypothesize that a machine learning model built on temporal principal component analysis (PCA) of dynamic susceptibility contras
Externí odkaz:
https://doaj.org/article/f3997d4247b045488e4da9cb506d56e2
Autor:
Fan Yang, Zhenqiang He, Hao Duan, Duo Zhang, Juehui Li, Huijuan Yang, Jay F. Dorsey, Wei Zou, S. Ali Nabavizadeh, Stephen J. Bagley, Kalil Abdullah, Steven Brem, Lin Zhang, Xiaowei Xu, Katelyn T. Byrne, Robert H. Vonderheide, Yanqing Gong, Yi Fan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Glioblastomas are generally resistant to treatment with immune checkpoint inhibitors. Here the authors show that IL6 blockade, in combination with a CD40 agonist, overcomes macrophage-mediated immunosuppression and sensitizes glioblastoma to immune c
Externí odkaz:
https://doaj.org/article/b5c127f1aaa240298e7d6cf386dcde4f
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
IntroductionThe lateral habenula (LHb) is an epithalamic nucleus associated with negative valence and affective disorders. It receives input via the stria medullaris (SM) and sends output via the fasciculus retroflexus (FR). Here, we use tractography
Externí odkaz:
https://doaj.org/article/19b0f692140c40f58a2b758e2b94b860