Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Steven, Boakes"'
Autor:
Antoinette Wilson, Roy Lester, S. R. Moss, Mona Simonovic, Naomi Divall, Esther Duperchy, Sonia Ganeshwaran, Omar Abdulle, Steven Boakes, Jaspal Singh, Michael J. Dawson, Pamela Brown, Steven J. Stanway, Rivers Dean Andrew
Publikováno v:
ACS Infect Dis
Novel polymyxin derivatives are often classified either as having direct activity against Gram-negative pathogens or as compounds inactive in their own right, which through permeabilization of the outer membrane act as potentiators of other antibioti
Autor:
Pamela Brown, Steven Boakes, Steven J. Stanway, S. R. Moss, Antoinette Wilson, Esther Duperchy, Mona Simonovic, Michael J. Dawson, Omar Abdulle
Publikováno v:
Bioorg Med Chem Lett
Synthetic modifications have been made directly to the cyclic peptide core of polymyxin B, enabling the further understanding of structure activity relationships of this antimicrobial peptide. Such modified polymyxins are also substrates for enzymic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b216ccca9c7c07fbab7b28be32d3e4b
https://europepmc.org/articles/PMC7215238/
https://europepmc.org/articles/PMC7215238/
Autor:
Rivers Dean Andrew, Pamela Brown, Elizabeth Abbott, Steven Boakes, S. R. Moss, Omar Abdulle, Jaspal Singh, Naomi Divall, Steven Stanway, Michael J. Dawson, Scott Coleman, Esther Duperchy, Mona Simonovic, Antoinette Wilson
Publikováno v:
ACS Infect Dis
Polymyxins are an important class of antibiotics for the treatment of bacterial infections due to multidrug resistant Gram-negative pathogens. However, their clinical utility is limited by nephrotoxicity. Here, we report a series of promising next ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6748c960aa2555fcadf99d8031fdfa41
https://europepmc.org/articles/PMC8152168/
https://europepmc.org/articles/PMC8152168/
Publikováno v:
The Journal of Antibiotics. 69:850-857
NVB333 is a novel semisynthetic lantibiotic derived from the amide coupling of 3,5-dichlorobenzylamine to the C-terminal of deoxyactagardine B. The in vitro activity of NVB333 includes efficacy against clinically relevant pathogens including methicil
Autor:
R. Gaber, Steven Boakes, Peter F. Leadlay, Dušan Goranovič, V. Magdevska, Enej Kuščer, M.B. Durán Alonso, Hrvoje Petković, Ramón I. Santamaría, Peter Raspor, Štefan Fujs
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Industrial overproducing strains present unique hosts for expression of heterologous gene clusters encoding secondary metabolite biosynthesis. For this purpose, efficient gene expression tools and methods are needed. A robust and versatile reporter s
Autor:
Ines U Böhm, Brian A.M. Rudd, Peter F. Leadlay, Steven Boakes, Markiyan Oliynyk, J. Staunton, Jesus Cortes, W P Revill
Publikováno v:
Microbial Physiology. 8:73-80
A previously unidentified set of genes encoding a modular polyketide synthase (PKS) has been sequenced in Saccharopolyspora erythraea, producer of the antibiotic erythromycin. This new PKS gene cluster (pke) contains four adjacent large open reading
Autor:
Steven Boakes, Michael J. Dawson
Publikováno v:
Natural Products
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fd2e28df596cc633e42e5dd0a986336
https://doi.org/10.1002/9781118794623.ch24
https://doi.org/10.1002/9781118794623.ch24
Autor:
Jesus Cortes, Steven Boakes, Michael J. Dawson, Tania Ayala, Mark Herman, Antony N. Appleyard
Publikováno v:
Applied microbiology and biotechnology. 95(6)
The lantibiotic actagardine A is nineteen amino acids in length and comprises three intertwined C-terminal methyllanthionine-bridged rings and an N-terminal lanthionine-bridged ring. Produced by the actinomycete Actinoplanes garbadinensis ATCC 31049,
Publikováno v:
The Journal of antibiotics. 63(7)
Deoxyactagardine B (DAB) is a hitherto unknown type B lantibiotic, produced by Actinoplanes liguriae NCIMB41362. The mature peptide is 19 amino acids in length and structurally analogous to actagardine, differing by two amino acids (V15L and I16V) an
Publikováno v:
Molecular microbiology. 72(5)
Summary The biosynthetic pathway of the type B lantibiotic actagardine (formerly gardimycin), produced by Actinoplanes garbadinensis ATCC31049, has been cloned, sequenced and annotated. The gene cluster contains the gene garA that encodes the actagar