Research routes on awake bruxism metrics: implications of the updated bruxism definition and evaluation strategies

Autor: Alessandro Bracci, Frank Lobbezoo, Anna Colonna, Steven Bender, Paulo C. R. Conti, Alona Emodi‐Perlman, Birgitta Häggman‐Henrikson, Gary D. Klasser, Ambra Michelotti, Gilles J. Lavigne, Peter Svensson, Jari Ahlberg, Daniele Manfredini

Publikováno v: Journal of Oral Rehabilitation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::618a446f72bbdaffc105b0459b3ee4e0
https://doi.org/10.1111/joor.13514

Supplementary Table 1 from EGF816 Exerts Anticancer Effects in Non–Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor

Autor: Shailaja Kasibhatla, Steven Bender, Jennifer Harris, Peter McNamara, Pierre-Yves Michellys, Jeffrey A. Engelman, Nuzhat Pathan, Thomas H. Marsilje, Robert Epple, Matthew McNeill, Jordi Barretina, Gerald Lelais, Badry Bursulaya, Michael DiDonato, Eric Murphy, Debbie Liao, Carlotta Costa, Jennifer Anderson, Chun Li, Elizabeth L. Lockerman, AnneMarie Culazzo Pferdekamper, Mei-Ting Vaillancourt, Noelito Timple, Celin Tompkins, Matthew J. Niederst, Mari Manuia, Jie Li, Jose Juarez, Yong Jia

This file contains the supplementary Table S1 that describes the characteristics and anti-proliferative activities of EGF816 on a number of patient-derived cell lines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b02199c09204ac63e8515f8c075e07b
https://doi.org/10.1158/0008-5472.22409400

Supplementary Figures 1 through 5 from EGF816 Exerts Anticancer Effects in Non–Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor

Autor: Shailaja Kasibhatla, Steven Bender, Jennifer Harris, Peter McNamara, Pierre-Yves Michellys, Jeffrey A. Engelman, Nuzhat Pathan, Thomas H. Marsilje, Robert Epple, Matthew McNeill, Jordi Barretina, Gerald Lelais, Badry Bursulaya, Michael DiDonato, Eric Murphy, Debbie Liao, Carlotta Costa, Jennifer Anderson, Chun Li, Elizabeth L. Lockerman, AnneMarie Culazzo Pferdekamper, Mei-Ting Vaillancourt, Noelito Timple, Celin Tompkins, Matthew J. Niederst, Mari Manuia, Jie Li, Jose Juarez, Yong Jia

This file shows the Supplementary figures. Figure S1 shows the chemical structure of EGF816 and its binding to EGFR T790M mutant. Figure S2 shows the tolerability of EGF816 in the in vivo xenograft models. Figure S3 shows the in vivo PK and PD after

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081ab8464515db1aff3c0ba30b59f5d9
https://doi.org/10.1158/0008-5472.22409406.v1

Standardised Tool for the Assessment of Bruxism

Autor: Daniele Manfredini, Jari Ahlberg, Ghizlane Aarab, Steven Bender, Alessandro Bracci, Peter A. Cistulli, Paulo Cesar Conti, Reny De Leeuw, Justin Durham, Alona Emodi‐Perlman, Dominik Ettlin, Luigi M. Gallo, Birgitta Häggman‐Henrikson, Christer Hublin, Takafumi Kato, Gary Klasser, Michail Koutris, Gilles J. Lavigne, Daniel Paesani, Ingrid Peroz, Peter Svensson, Peter Wetselaar, Frank Lobbezoo

Publikováno v: Manfredini, D, Ahlberg, J, Aarab, G, Bender, S, Bracci, A, Cistulli, P A, Conti, P C, De Leeuw, R, Durham, J, Emodi-Perlman, A, Ettlin, D, Gallo, L M, Häggman-Henrikson, B, Hublin, C, Kato, T, Klasser, G, Koutris, M, Lavigne, G J, Paesani, D, Peroz, I, Svensson, P, Wetselaar, P & Lobbezoo, F 2023, ' Standardised Tool for the Assessment of Bruxism ', Journal of Oral Rehabilitation . https://doi.org/10.1111/joor.13411

Objective: This paper aims to present and describe the Standardised Tool for the Assessment of Bruxism (STAB), an instrument that was developed to provide a multidimensional evaluation of bruxism status, comorbid conditions, aetiology and consequence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fee6c3618b25ab8ab38bd681da68e0
https://hdl.handle.net/1871.1/7f775ff5-0f3a-4a02-949e-09e198140a03

Structure-Based Design of Selective LONP1 Inhibitors for Probing

Autor: Laura J, Kingsley, Xiaohui, He, Matthew, McNeill, John, Nelson, Victor, Nikulin, Zhiwei, Ma, Wenshuo, Lu, Vicki W, Zhou, Mari, Manuia, Andreas, Kreusch, Mu-Yun, Gao, Darbi, Witmer, Mei-Ting, Vaillancourt, Min, Lu, Sarah, Greenblatt, Christian, Lee, Ajay, Vashisht, Steven, Bender, Glen, Spraggon, Pierre-Yves, Michellys, Yong, Jia, Jacob R, Haling, Gérald, Lelais

Publikováno v: Journal of medicinal chemistry. 64(8)

LONP1 is an AAA+ protease that maintains mitochondrial homeostasis by removing damaged or misfolded proteins. Elevated activity and expression of LONP1 promotes cancer cell proliferation and resistance to apoptosis-inducing reagents. Despite the impo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e665e6a49bed89fff37af4eae908565f
https://pubmed.ncbi.nlm.nih.gov/33821636