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A Novel 1,3-Beta- d -Glucan Inhibitor, Ibrexafungerp (Formerly SCY-078), Shows Potent Activity in the Lower pH Environment of Vulvovaginitis

Autor: N. Isham, Steve Wring, David Angulo, Katyna Borroto-Esoda, Lisa Long, Stephen Barat, Emily L Larkin, Mahmoud A. Ghannoum

Publikováno v: Antimicrobial Agents and Chemotherapy. 63

Ibrexafungerp (IBX) (formerly SCY-078) is a novel glucan synthase inhibitor whose oral availability is being evaluated for efficacy against vulvovaginal candidiasis (VVC). Bioavailability and in vitro activity are important efficacy indicators, but a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2681493c90d5ce4c1a79b96b4377cdd3
https://doi.org/10.1128/aac.02611-18

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Simulating Intestinal Transporter and Enzyme Activity in a Physiologically Based Pharmacokinetic Model for Tenofovir Disoproxil Fumarate

Autor: Steve P. Rannard, Andrew Owen, Marco Siccardi, Steve Wring, Rajith K. R. Rajoli, Darren M. Moss, Melynda E. Watkins, Ryan Randolph, Seonghee Park, Paul L. Domanico, James J. Hobson

Publikováno v: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tenofovir disoproxil fumarate (TDF), a prodrug of tenofovir, has oral bioavailability (25%) limited by intestinal transport (P-glycoprotein), and intestinal degradation (carboxylesterase). However, the influence of luminal pancreatic enzymes is not f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960d86ad95272ee9e418e4f9666e4b5b

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The Emerging Pathogen Candida auris: Growth Phenotype, Virulence Factors, Activity of Antifungals, and Effect of SCY-078, a Novel Glucan Synthesis Inhibitor, on Growth Morphology and Biofilm Formation

Autor: Mauricio Retuerto, Iman Salem, Emily L Larkin, Christopher L. Hager, N. Isham, Pranab K. Mukherjee, David Angulo, Lisa Long, Jyotsna Chandra, Steve Wring, Katyna Borroto-Esoda, Mahmoud A. Ghannoum, Laura L. Kovanda

Publikováno v: Antimicrobial Agents and Chemotherapy

Candida auris , a new multidrug-resistant Candida spp. which is associated with invasive infection and high rates of mortality, has recently emerged. Here, we determined the virulence factors (germination, adherence, biofilm formation, phospholipase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2aa0bb0253621915f26cbb42195392d
http://europepmc.org/articles/PMC5404565

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[Untitled]

Autor: Sanna Tolle-Sander, Steve Wring, Jarkko Rautio, James E. Polli, Joseph W. Polli

Publikováno v: Pharmaceutical Research. 20:757-764

Purpose. The purpose of this study was to investigate whether midazolam exhibits characteristics of a highly permeable P-glycoprotein (P-gp) substrate and to evaluate the potential influence of P-gp inhibition on 1-OH midazolam formation during midaz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e986072c770355c242b3f903d2a9b07
https://doi.org/10.1023/a:1023433502647

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Midazolam exhibits characteristics of a highly permeable P-glycoprotein substrate

Autor: Sanna, Tolle-Sander, Jarkko, Rautio, Steve, Wring, Joseph W, Polli, James E, Polli

Publikováno v: Pharmaceutical research. 20(5)

The purpose of this study was to investigate whether midazolam exhibits characteristics of a highly permeable P-glycoprotein (P-gp) substrate and to evaluate the potential influence of P-gp inhibition on 1-OH midazolam formation during midazolam tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e68c59c4ee5197aa7abb58332d4d9a6d
https://pubmed.ncbi.nlm.nih.gov/12751631

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