Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Steve Weinheimer"'
Autor:
Edwin DeJesus, Catherine Creticos, Brinda Emu, Jason Leider, Steve Weinheimer, Mezgebe Berhe, Zvi Cohen
Publikováno v:
Open Forum Infectious Diseases
Background Ibalizumab (IBA), a humanized monoclonal antibody, is the first CD4-directed post-attachment HIV-1 inhibitor. It was approved by the FDA in March 2018 based on results from the pivotal Phase 3 TMB-301 clinical study. The TMB-311 expanded a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e61b44643e190439a45ff3064c6a57b5
http://europepmc.org/articles/PMC6811265
http://europepmc.org/articles/PMC6811265
Autor:
Andrew J. Staab, James M. Clark, Steve Weinheimer, Dennis Hernandez, James W. Janc, Joane Litvak, Emma J. Shelton, Jeffrey R. Spencer, Richard Goldsmith, Anthony R. Gangloff, Kenneth D. Rice, David Sperandio, Kap-Sun Yeung, Kyle Elrod, Brian Lee Venables, Nicholas A. Meanwell, Vivian R. Wang, Jason M. Hataye
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3129-3133
Screening of a diverse set of bisbenzimidazoles for inhibition of the hepatitis C virus (HCV) serine protease NS3/NS4A led to the identification of a potent Zn(2+)-dependent inhibitor (1). Optimization of this screening hit afforded a 10-fold more po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2bf90718813bb49178a8c8937321ab
https://doi.org/10.1016/s0960-894x(02)00680-7
https://doi.org/10.1016/s0960-894x(02)00680-7
Autor:
Nicholas A. Meanwell, Zhilei Qiu, Sharon Zhang, Kap-Sun Yeung, James M. Clark, Fiona McPhee, Dennis Hernandez, James W. Janc, Steve Weinheimer
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(17)
A survey of isosteric replacements of the phosphonoalanine side chain coupled with a process of conformational constraint of a bisbenzimidazole-based, Zn(2+)-dependent inhibitor of hepatitis C virus (HCV) NS3 serine protease resulted in the identific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000cf83074648368a1caf72de4a0a8c1
https://pubmed.ncbi.nlm.nih.gov/11527730
https://pubmed.ncbi.nlm.nih.gov/11527730