Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Steve Wagner"'
Autor:
Steven R. Whittaker, Clare Barlow, Mathew P. Martin, Caterina Mancusi, Steve Wagner, Annette Self, Elaine Barrie, Robert Te Poele, Swee Sharp, Nathan Brown, Stuart Wilson, Wayne Jackson, Peter M. Fischer, Paul A. Clarke, Michael I. Walton, Edward McDonald, Julian Blagg, Martin Noble, Michelle D. Garrett, Paul Workman
Publikováno v:
Molecular Oncology, Vol 12, Iss 3, Pp 287-304 (2018)
Deregulation of the cyclin‐dependent kinases (CDKs) has been implicated in the pathogenesis of multiple cancer types. Consequently, CDKs have garnered intense interest as therapeutic targets for the treatment of cancer. We describe herein the molec
Externí odkaz:
https://doaj.org/article/fe1e3db27bb44f2e82c1a7b2ffc32006
Autor:
Thomas Höfner, Christian Eisen, Corinna Klein, Teresa Rigo-Watermeier, Stephan M. Goeppinger, Anna Jauch, Brigitte Schoell, Vanessa Vogel, Elisa Noll, Wilko Weichert, Irène Baccelli, Anja Schillert, Steve Wagner, Sascha Pahernik, Martin R. Sprick, Andreas Trumpp
Publikováno v:
Stem Cell Reports, Vol 4, Iss 3, Pp 503-518 (2015)
Methods to isolate and culture primary prostate epithelial stem/progenitor cells (PESCs) have proven difficult and ineffective. Here, we present a method to grow and expand both murine and human basal PESCs long term in serum- and feeder-free conditi
Externí odkaz:
https://doaj.org/article/33f168c807c34e308fe95cb2b77e3c7c
Autor:
Silvia von der Heyde, Steve Wagner, Alexander Czerny, Manuel Nietert, Fabian Ludewig, Gabriela Salinas-Riester, Dorit Arlt, Tim Beißbarth
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117818 (2015)
Intrinsic and acquired resistance to the monoclonal antibody drug trastuzumab is a major problem in the treatment of HER2-positive breast cancer. A deeper understanding of the underlying mechanisms could help to develop new agents. Our intention was
Externí odkaz:
https://doaj.org/article/28db76114a6e424c950c3ebb795b6938
Autor:
Grzegorz S. Nowakowski, Johannes Duell, Katerina Kopeckova, Marek Trneny, Christiane Pott, Mouhamad Khouja, John M. Burke, Maeve Waldron-Lynch, Steve Wagner, Amitava Mukhopadhyay, Derek Blair, David Belada
Publikováno v:
Blood. 140:3731-3733
Autor:
Umberto Vitolo, Grzegorz S. Nowakowski, John M. Burke, Christopher P. Fox, Marek Trneny, Annalisa Chiappella, Maeve Waldron-Lynch, Steve Wagner, Alok Pachori, Georg Lenz
Publikováno v:
Blood. 140:6618-6620
Autor:
Levi A. Garraway, David E. Root, Flora Luo, Steve Wagner, Glenn S. Cowley, Steven R. Whittaker
RAF and MEK inhibitors are effective in BRAF-mutant melanoma but not in BRAF-mutant colorectal cancer. To gain additional insights into this difference, we performed a genome-scale pooled shRNA enhancer screen in a BRAF-mutant, RAF inhibitor–resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::800a362e1a5f12e2e3e01375aeed7dc0
https://doi.org/10.1158/1535-7163.c.6536584.v1
https://doi.org/10.1158/1535-7163.c.6536584.v1
Autor:
Levi A. Garraway, David E. Root, Flora Luo, Steve Wagner, Glenn S. Cowley, Steven R. Whittaker
Figure S1: Following BRAF inhibition, recovery of ERK phosphorylation is observed and RKO cells continue to proliferate in the presence of PLX4720. Figure S2: DAPPLE analysis of the top 300 candidate genes from the primary screen identifies potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d670865b3e6063080abfdde05b4ad9e
https://doi.org/10.1158/1535-7163.22500832.v1
https://doi.org/10.1158/1535-7163.22500832.v1
Autor:
Levi A. Garraway, David E. Root, Flora Luo, Steve Wagner, Glenn S. Cowley, Steven R. Whittaker
RNAi gene enrichment (RIGER) analysis of the primary screen.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e158dcb0e73cbd574211e0b82c47bed
https://doi.org/10.1158/1535-7163.22500829.v1
https://doi.org/10.1158/1535-7163.22500829.v1
Autor:
Fabrizio Zullo, Daniele Di Mascio, Nandini Raghuraman, Steve Wagner, Roberto Brunelli, Antonella Giancotti, Hector Mendez-Figueroa, Alison G. Cahill, Megha Gupta, Vincenzo Berghella, Sean C. Blackwell, Suneet P. Chauhan
Publikováno v:
American Journal of Obstetrics and Gynecology.
Autor:
David M. Kurtz, Gregory J. Hogan, Andre Schultz, Katerina Kopeckova, Christian Kuffer, Derek Blair, Steve Wagner, Sandra Close, Maximilian Diehn, Jacob J. Chabon, Ash A. Alizadeh, Jason Westin
Publikováno v:
Blood. 140:3498-3499