Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Steve Vanderroest"'
Autor:
Mark C. Sulavik, Debra Hanna, Bill Dunkle, Li Ann Wang, V. Hayden Thomas, Laura A. Skerlos, Tong Zhu, Chris Limberakis, Zhigang Wang, Amy Whitton, Michael Kuhn, C. Kendall Stover, Jeff Ohren, John A. Shelly, J.V.N. Vara Prasad, Steve Dunham, H. James Harwood, Michael D. Huband, J. Richard Miller, Shawn Mehrens, Alla Karnovsky, Susan Buist, W. Thomas Mueller, Jia Y. Liu, Steve Vanderroest, Craig Banotai, Adam Ogden, Lakshmi Narasimhan, Matthew Bowman, Igor Mochalkin
Publikováno v:
Proceedings of the National Academy of Sciences. 106:1737-1742
As the need for novel antibiotic classes to combat bacterial drug resistance increases, the paucity of leads resulting from target-based antibacterial screening of pharmaceutical compound libraries is of major concern. One explanation for this lack o
Autor:
Bradley D. Tait, Susan Elizabeth Hagen, Michael Lovdahl, Eric Andrew Zeikus, Carolyn Nouhan, Joanne Brodfuehrer, Donald Hupe, Christopher Andrew Gajda, John M. Domagala, Greg Zeikus, Elizabeth A. Lunney, Steve Vanderroest, Alexander Pavlovsky, Andrej Urumov, James Saunders, Stephen J. Gracheck, Eric Wise, Tod P. Holler
Publikováno v:
Journal of Medicinal Chemistry. 44:2319-2332
Due largely to the emergence of multi-drug-resistant HIV strains, the development of new HIV protease inhibitors remains a high priority for the pharmaceutical industry. Toward this end, we previously identified a 4-hydroxy-5,6-dihydropyrone lead com