Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Steve Tuske"'
Autor:
Juliette Hordeaux, Ali Ramezani, Steve Tuske, Nickita Mehta, Chunjuan Song, Anna Lynch, Katherine Lupino, Jessica A. Chichester, Elizabeth L. Buza, Cecilia Dyer, Hongwei Yu, Peter Bell, Jill M. Weimer, Hung Do, James M. Wilson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Immune responses to human non-self transgenes can present challenges in preclinical studies of adeno-associated virus (AAV) gene therapy candidates in nonhuman primates. Although anti-transgene immune responses are usually mild and non-adverse, they
Externí odkaz:
https://doaj.org/article/399a575278114cbda824ff19d97176ed
Autor:
Ian Keyzor, Simon Shohet, Jeff Castelli, Sheela Sitaraman, Biliana Veleva-Rotse, Jill M. Weimer, Brian Fox, Tobias Willer, Steve Tuske, Louise Crathorne, Klara J. Belzar
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1227 (2023)
The treatment landscape for lysosomal storage disorders (LSDs) is rapidly evolving. An increase in the number of preclinical and clinical studies in the last decade has demonstrated that pharmacological chaperones are a feasible alternative to enzyme
Externí odkaz:
https://doaj.org/article/77e7ce7c2b764f51880d261188c06a9c
Autor:
Steve Tuske, Jie Zheng, Erik D. Olson, Francesc X. Ruiz, Bruce D. Pascal, Anthony Hoang, Joseph D. Bauman, Kalyan Das, Jeffrey J. DeStefano, Karin Musier-Forsyth, Patrick R. Griffin, Eddy Arnold
Publikováno v:
Current Research in Structural Biology, Vol 2, Iss , Pp 116-129 (2020)
The high-resolution crystal structure of HIV-1 reverse transcriptase (RT) bound to a 38-mer DNA hairpin aptamer with low pM affinity was previously described. The high-affinity binding aptamer contained 2′-O-methyl modifications and a seven base-pa
Externí odkaz:
https://doaj.org/article/7cba558dc6d74f5ca1cdc54c01017b4e
Autor:
Jerry Joe E. K. Harrison, Steve Tuske, Kalyan Das, Francesc X. Ruiz, Joseph D. Bauman, Paul L. Boyer, Jeffrey J. DeStefano, Stephen H. Hughes, Eddy Arnold
Publikováno v:
Viruses, Vol 13, Iss 8, p 1495 (2021)
In most cases, proteolytic processing of the retroviral Pol portion of the Gag-Pol polyprotein precursor produces protease (PR), reverse transcriptase (RT), and integrase (IN). However, foamy viruses (FVs) express Pol separately from Gag and, when Po
Externí odkaz:
https://doaj.org/article/d2a2429c574c4515b047df0567c30b54
Autor:
Yu Zhang, David Degen, Mary X Ho, Elena Sineva, Katherine Y Ebright, Yon W Ebright, Vladimir Mekler, Hanif Vahedian-Movahed, Yu Feng, Ruiheng Yin, Steve Tuske, Herbert Irschik, Rolf Jansen, Sonia Maffioli, Stefano Donadio, Eddy Arnold, Richard H Ebright
Publikováno v:
eLife, Vol 3 (2014)
Using a combination of genetic, biochemical, and structural approaches, we show that the cyclic-peptide antibiotic GE23077 (GE) binds directly to the bacterial RNA polymerase (RNAP) active-center ‘i’ and ‘i+1’ nucleotide binding sites, preven
Externí odkaz:
https://doaj.org/article/f4f3d502427d47b09fde0b71d754abf6
Autor:
Jie Zheng, Anthony Hoang, Steve Tuske, Kalyan Das, Erik D. Olson, Joseph D. Bauman, Bruce D. Pascal, Karin Musier-Forsyth, Eddy Arnold, Francesc X. Ruiz, Jeffrey J. DeStefano, Patrick R. Griffin
Publikováno v:
Current Research in Structural Biology, Vol 2, Iss, Pp 116-129 (2020)
Current research in structural biology
Current research in structural biology
The high-resolution crystal structure of HIV-1 reverse transcriptase (RT) bound to a 38-mer DNA hairpin aptamer with low pM affinity was previously described. The high-affinity binding aptamer contained 2′-O-methyl modifications and a seven base-pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a1736e5cfc877111f4c0ef68a8422d
http://www.sciencedirect.com/science/article/pii/S2665928X20300131
http://www.sciencedirect.com/science/article/pii/S2665928X20300131
Autor:
Thomas Gremminger, Liming Qiu, Dong Zhang, Xiaoqin Zou, Jie Zheng, Phuong D.M. Nguyen, Xiao Heng, Margaret J. Lange, Eddy Arnold, Steve Tuske, Patrick R. Griffin, Donald H. Burke, Shi-Jie Chen
Publikováno v:
Nucleic Acids Research
RNA aptamers that bind HIV-1 reverse transcriptase (RT) inhibit RT in enzymatic and viral replication assays. Some aptamers inhibit RT from only a few viral clades, while others show broad-spectrum inhibition. Biophysical determinants of recognition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343544baa5a3d97d13c96763cc9c7a56
https://pubmed.ncbi.nlm.nih.gov/31943114
https://pubmed.ncbi.nlm.nih.gov/31943114
Structure of HIV-1 reverse transcriptase bound to a novel 38-mer hairpin template-primer DNA aptamer
Publikováno v:
Protein Science. 25:46-55
The development of a modified DNA aptamer that binds HIV-1 reverse transcriptase (RT) with ultra-high affinity has enabled the X-ray structure determination of an HIV-1 RT-DNA complex to 2.3 A resolution without the need for an antibody Fab fragment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a186eca0ce0b86d1b59c15f60dc748b5
https://doi.org/10.1002/pro.2776
https://doi.org/10.1002/pro.2776
Autor:
Eddy Arnold, Yongzheng Zhang, Edmond J. LaVoie, Ajit K. Parhi, Daniel S. Pilch, Steve Tuske, John E. Kerrigan, Malvika Kaul
Publikováno v:
Biochimie. 95:1880-1887
New antibiotics with novel mechanisms of action are urgently needed to overcome the growing bacterial resistance problem faced by clinicians today. PC190723 and related compounds represent a promising new class of antibacterial compounds that target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b1be7782e70e43160f62d3bbdd5fcd
https://doi.org/10.1016/j.biochi.2013.06.010
https://doi.org/10.1016/j.biochi.2013.06.010
Autor:
Bruce D. Pascal, Joseph D. Bauman, D. Patel, Devrishi Goswami, Steve Tuske, Eddy Arnold, Patrick R. Griffin
Publikováno v:
Analytical chemistry. 87(7)
Hydrogen/deuterium exchange (HDX) coupled to mass spectrometry has emerged as a powerful tool for analyzing the conformational dynamics of protein-ligand and protein-protein interactions. Recent advances in instrumentation and methodology have expand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab39de52306460d7150d0fda4dbb20ca
https://pubmed.ncbi.nlm.nih.gov/25763479
https://pubmed.ncbi.nlm.nih.gov/25763479