Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Steve Tam"'
Autor:
Pooja Devan, Kai Le Ashley Tiong, Jean Ee Neo, Babu P. Mohan, Karn Wijarnpreecha, Yew Chong Steve Tam, Nicola Coppola, Carmen Monica Preda, Yu Jun Wong
Publikováno v:
Viruses, Vol 15, Iss 7, p 1489 (2023)
About 5% of chronic hepatitis C (CHC) patients experienced treatment failure with direct-acting antiviral (DAA) treatment. The global data on the practice and treatment outcomes of Sofosbuvir/Velpatasvir/Voxilaprevir (SOF/VEL/VOX) in DAA-experienced
Externí odkaz:
https://doaj.org/article/9861a3c10d5e48a4819e41f53385edac
Publikováno v:
International Journal of Dermatology. 61:1311-1324
Treatment guidelines are not well established in AIDS-related Kaposi sarcoma (KS).We aim to review the evidence on efficacy of treatments for AIDS-related Kaposi sarcoma.We searched the Cochrane Library, PubMed, and Embase Database from date of datab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10df18d5a1e7f769f5a052b571a00cb
https://doi.org/10.1111/ijd.16318
https://doi.org/10.1111/ijd.16318
Autor:
Yonghan Hu, Jennifer R. Thomason, Steve Tam, Priya S. Chockalingam, Erica Reifenberg, Manus Ipek, Jason Shaoyun Xiang, Huan-Qiu Li, Richard Sheldon, Li Xing, Elisabeth A. Morris, Joshua James Sabatini, Katy E. Georgiadis, Satenig Guler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6800-6803
Design, synthesis and structure–activity relationship of a series of biphenylsulfonamido-3-methylbutanoic acid based aggrecanase-1 inhibitors are described. In addition to robust aggrecanase-1 inhibition, these compounds also exhibit potent MMP-13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06996759f6d930ba801380ed1352ce5
https://doi.org/10.1016/j.bmcl.2011.09.036
https://doi.org/10.1016/j.bmcl.2011.09.036
Autor:
Steve Tam, Qin Wang, Adrian Huang, Desiree H.H. Tsao, Natalia Sushkova, Michael Dennis Lowe, Gray D. Shaw, Patricia W. Bedard, Li Di, Boris Tchernychev, James C. Keith, Neelu Kaila, Robert G. Schaub, Kristin Janz, Valerie Clerin, Alessandro Moretto
Publikováno v:
Journal of Medicinal Chemistry. 53:6003-6017
Previously, we reported the discovery of PSI-697 (1a), a C-2 benzyl substituted quinoline salicylic acid-based P-selectin inhibitor. It is active in a variety of animal models of cardiovascular disease. Compound 1a has also been shown to be well tole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037abec3fb0ac922950e891045ae2fb2
https://doi.org/10.1021/jm9013696
https://doi.org/10.1021/jm9013696
Autor:
Debra G. Goodwin, Tarek S. Mansour, Kenneth C. Appell, Katherine J. Seidl, Amha G. Hewet, Maria L. Webb, Min Gao, James D. Clark, Steve Tam, Martin Hegen, Elizabeth Quadros, Peter T. Symanowicz, Jenny Togias, Jennifer Lussier, Scott H. Schelling, Michael Ohlmeyer, Bojing Wang, Xin Xu, Earl F. Kimble, Mary Collins, Jorge Quintero, Rustem Krykbaev, Dejun Xuan, Cheryl Nickerson-Nutter, Richard Harrison, Yuefei Shao, Christopher Wrocklage, Tsung H. Lin, Andrew G. Cole
Publikováno v:
Arthritis & Rheumatism. 62:2283-2293
Objective All γ-chain cytokines signal through JAK-3 and JAK-1 acting in tandem. We undertook this study to determine whether the JAK-3 selective inhibitor WYE-151650 would be sufficient to disrupt cytokine signaling and to ameliorate autoimmune dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef4a0c33e1ad1789a4ae6c55e946b7c
https://doi.org/10.1002/art.27536
https://doi.org/10.1002/art.27536
Autor:
Yuchuan Wu, Paul Morgan, Nathan O. Fuller, Wei Li, Samuel J. Goldman, Raveglia Luca Francesco, Cara M. M. Williams, Rustem Krykbaev, Joseph P. Sypek, Kristina Cunningham, Junjun Wu, William W Abraham, Fabio Rancati, Xin Xu, Steve Tam, Jianchang Li, Susan Fish, Tarek S. Mansour, Stefania Vallese, Rajeev Hotchandani
Publikováno v:
Journal of medicinal chemistry. 52(17)
MMP-12 plays a significant role in airway inflammation and remodeling. Increased expression and production of MMP-12 have been observed in the lungs of asthmatic patients. Compound 27 was identified as a potent and selective MMP-12 inhibitor possessi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f793a6a9bdbb17167c21f086cb947804
https://pubmed.ncbi.nlm.nih.gov/19725580
https://pubmed.ncbi.nlm.nih.gov/19725580
Autor:
Manus Ipek, Cheryl L. Nickerson-Nutter, Marina W.H. Shen, Elizabeth A. Murphy, Martin Hegen, Cara Williams, Kun Wu, James C. Keith, Baihua Hu, Steven J. Kirincich, Paresh Thakker, Ronald S Michalak, Katherine L. Lee, John C. McKew, James D. Clark, Leo Albert, Steve Tam, Lihren Chen, Manjunath K. Ramarao, Yonghan Hu, Debra G. Goodwin, Xin Xu, Sum Fuk-Wah, Mark L. Behnke, Frances Donahue, Megan A. Foley, M. Sherry Ku, Jennifer Thomason, William M. Abraham, Lane Wooder
Publikováno v:
Journal of medicinal chemistry. 51(12)
The optimization of a class of indole cPLA 2 alpha inhibitors is described herein. The importance of the substituent at C3 and the substitution pattern of the phenylmethane sulfonamide region are highlighted. Optimization of these regions led to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d0ce05d3b971757ea8be4ba47a741f
https://pubmed.ncbi.nlm.nih.gov/18498150
https://pubmed.ncbi.nlm.nih.gov/18498150
Autor:
James F, Tobin, Steve, Tam
Publikováno v:
Current opinion in drug discoverydevelopment. 5(4)
Protein tyrosine phosphatases (PTPs) are a large family of diverse molecules that play an important role in both activating and attenuating a wide variety of cellular responses. One of these phosphatases, protein tyrosine phosphatase 1B (PTP1B), is c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::56333f884186ba02cda6caa602667c2e
https://pubmed.ncbi.nlm.nih.gov/12197308
https://pubmed.ncbi.nlm.nih.gov/12197308
Autor:
Philip Kaaret, Steve Tammes, Jun Wang, Thomas Schnell, Marc Linderman, Carlton H. Richey, Colin M. Packard, Meng Zhou, Chase A. Fuller
Publikováno v:
Remote Sensing, Vol 14, Iss 19, p 5019 (2022)
The severity of wildfires is increasing and has driven increases in nighttime fire activity. Enhanced capability to detect the active burning regions of wildfires at night could significantly improve the effectiveness of wildfire management operation
Externí odkaz:
https://doaj.org/article/48abf9e20fa748c9b7318251d13711ae
Autor:
Hsu Ming-Chu, Steve Tam
Publikováno v:
The Search for Antiviral Drugs ISBN: 9781489967206
One area in which molecular virology has made major advances seems largely to have escaped the attention of pharmacologists. This is the study of how viruses regulate their gene expression. Advances in this area have been due to the fact that, being
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d22e0b95762460eaf1f013de68f39e38
https://doi.org/10.1007/978-1-4899-6718-3_7
https://doi.org/10.1007/978-1-4899-6718-3_7
