Detection of Pseudomonas aeruginosa biomarkers from thermally injured mice in situ using imaging mass spectrometry

Autor: Brian Bothner, Kendra P. Rumbaugh, Nina Paris, Arivarasan Karunamurthy, Steve T. Fisher, Daniel D. Rhoads, Jake Everett, Timothy Hamerly, Garth A. James

Publikováno v: Analytical Biochemistry. 539:144-148

Monitoring patients with burn wounds for infection is standard practice because failure to rapidly and specifically identify a pathogen can result in poor clinical outcomes, including death. Therefore, a method that facilitates detection and identifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb66a32b6a7f714318cc1a1878fd20f
https://doi.org/10.1016/j.ab.2017.10.012

Conceptual Model of Biofilm Antibiotic Tolerance That Integrates Phenomena of Diffusion, Metabolism, Gene Expression, and Physiology

Autor: Philip S. Stewart, Brian Bothner, Laura Boegli, Michael J. Franklin, Garth A. James, Anders Wallqvist, Kerry S. Williamson, Ben White, Steve T. Fisher, Francisco G. Vital-Lopez, Timothy Hamerly

Publikováno v: Journal of Bacteriology. 201

Transcriptomic, metabolomic, physiological, and computational modeling approaches were integrated to gain insight into the mechanisms of antibiotic tolerance in an in vitro biofilm system. Pseudomonas aeruginosa biofilms were grown in drip flow react

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acad5c5c2efa471c94da7b73801b407b
https://doi.org/10.1128/jb.00307-19

Propionibacterium acnes biofilm is present in intervertebral discs of patients undergoing microdiscectomy

Autor: Radim Lipina, Garth A. James, Ondrej Slaby, John C. Baird, Jiri Sana, Nitin N. Bhatia, Christof Birkenmaier, Jeffrey C. Wang, A. Nick Shamie, Assaf Raz, Robert K. Eastlack, Jerry Stonemetz, Filip Ruzicka, Steven R. Garfin, Neel Anand, Elleni Michu, Jonathan E. Schmitz, Philip S. Stewart, Radim Jančálek, Jaspaul S. Gogia, Vincent A. Fischetti, Tana Machackova, Konstantinos Mavrommatis, Michael F. Coscia, Fahad S. Ahmed, Steve T. Fisher, Hana Nosková, Timothy F. Witham, Yu-Po Lee, Manu N. Capoor, Ziya L. Gokaslan, Martin Smrčka, Calvin C. Kuo, Todd Alamin, Sibel Demir-Deviren

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0174518 (2017)
PLoS ONE
Capoor, Manu N; Ruzicka, Filip; Schmitz, Jonathan E; James, Garth A; Machackova, Tana; Jancalek, Radim; et al.(2017). Propionibacterium acnes biofilm is present in intervertebral discs of patients undergoing microdiscectomy.. PloS one, 12(4), e0174518-e01745e0174518. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/8qn97751

Background In previous studies, Propionibacterium acnes was cultured from intervertebral disc tissue of similar to 25% of patients undergoing microdiscectomy, suggesting a possible link between chronic bacterial infection and disc degeneration. Howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6a5a2b81d6a470589f8ce8eb8caf9e
http://europepmc.org/articles/PMC5378350?pdf=render

Efficacy of Polyhexamethylene Biguanide-containing Antimicrobial Foam Dressing Against MRSA Relative to Standard Foam Dressing

Autor: Kelly R, Kirker, Steve T, Fisher, Garth A, James, Diane, McGhee, Chirag B, Shah

Publikováno v: Wounds : a compendium of clinical research and practice. 21(9)

Many modern foam wound dressings possess a variety of attributes that are designed to create a supportive wound-healing environment. These attributes include absorbing exudate, providing optimum moisture balance at the wound surface, and preventing m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5c2aaf5fab9d541e59667364d5531a3e
https://pubmed.ncbi.nlm.nih.gov/25903814

Iron induces bimodal population development by Escherichia coli

Autor: Steve T. Fisher, Matthew George Chapman, Luz P. Blanco, John S. Lee, Philip S. Stewart, David A. Hufnagel, Hans C. Bernstein, Garth A. James, William H. DePas

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 110(7)

Bacterial biofilm formation is a complex developmental process involving cellular differentiation and the formation of intricate 3D structures. Here we demonstrate that exposure to ferric chloride triggers rugose biofilm formation by the uropathogeni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33e4c90d6951327de613425cdab23db
https://pubmed.ncbi.nlm.nih.gov/23359678