CD40 Generation 2.5 Antisense Oligonucleotide Treatment Attenuates Doxorubicin-induced Nephropathy and Kidney Inflammation

Autor: Aaron J Donner, Steve T Yeh, Gene Hung, Mark J Graham, Rosanne M Crooke, Adam E Mullick

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)

Preclinical and clinical data suggest CD40 activation contributes to renal inflammation and injury. We sought to test whether upregulation of CD40 in the kidney is a causative factor of renal pathology and if reduction of renal CD40 expression, using

Externí odkaz: https://doaj.org/article/7d580cead0ee4bb8bf6901d073fb5063

Virus-Derived Chemokine Modulating Protein Pre-Treatment Blocks Chemokine–Glycosaminoglycan Interactions and Significantly Reduces Transplant Immune Damage

Autor: Isabela R. Zanetti, Michelle Burgin, Liqiang Zhang, Steve T. Yeh, Sriram Ambadapadi, Jacquelyn Kilbourne, Jordan R. Yaron, Kenneth M. Lowe, Juliane Daggett-Vondras, David Fonseca, Ryan Boyd, Dara Wakefield, William Clapp, Efrem Lim, Hao Chen, Alexandra Lucas

Publikováno v: Pathogens, Vol 11, Iss 5, p 588 (2022)

Immune cell invasion after the transplantation of solid organs is directed by chemokines binding to glycosaminoglycans (GAGs), creating gradients that guide immune cell infiltration. Renal transplant is the preferred treatment for end stage renal fai

Externí odkaz: https://doaj.org/article/bbb724add4e147c6b3a43ea6381638af

Antisense Therapy Attenuates Phospholamban p.(Arg14del) Cardiomyopathy in Mice and Reverses Protein Aggregation

Autor: Tim R. Eijgenraam, Nienke M. Stege, Vivian Oliveira Nunes Teixeira, Remco de Brouwer, Elisabeth M. Schouten, Niels Grote Beverborg, Liu Sun, Daniela Später, Ralph Knöll, Kenny M. Hansson, Carl Amilon, David Janzén, Steve T. Yeh, Adam E. Mullick, Peter van der Meer, Rudolf A. de Boer, Herman H. W. Silljé

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 5; Pages: 2427
International Journal of Molecular Sciences, 23(5):2427. MDPI AG

Inherited cardiomyopathy caused by the p.(Arg14del) pathogenic variant of the phospholamban (PLN) gene is characterized by intracardiomyocyte PLN aggregation and can lead to severe dilated cardiomyopathy. We recently reported that pre-emptive depleti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1573a1ccf665aed6a3e7cd2d10b644c

Whole-Body but Not Hepatic Knockdown of Chemerin by Antisense Oligonucleotide Decreases Blood Pressure in Rats

Autor: Adam E. Mullick, Janice M. Thompson, David J. Ferland, Emma S. Darios, Bridget M Seitz, Steve T. Yeh, Stephanie W. Watts

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 365:212-218

Chemerin is an inflammatory adipokine positively associated with hypertension and obesity. The majority of chemerin derives from the liver and adipose tissue, however, their individual contributions to blood pressure are unknown. We began studying ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02c3dc39889413e9e6508d71dc5b7f6
https://doi.org/10.1124/jpet.117.245456

Endothelial cell CD36 optimizes tissue fatty acid uptake

Autor: Shuiqing Yu, Steve T Yeh, Xiang Fang, Nada A. Abumrad, Ni-Huiping Son, Dmitri Samovski, Tenzin Lhakhang, Konstantinos Drosatos, Ira J. Goldberg, Kooresh I. Shoghi, Namrata Gumaste, Svetlana Bagdasarov, Florian Willecke, Fei Sun, Lesley-Ann Huggins, Adam E. Mullick, Vivek S. Peche, Terri A. Pietka, Diego Scerbo, Kyeong Jin Kim, Debapriya Basu, Hye Rim Chang

Publikováno v: The Journal of clinical investigation. 128(10)

Movement of circulating fatty acids (FAs) to parenchymal cells requires their transfer across the endothelial cell (EC) barrier. The multiligand receptor cluster of differentiation 36 (CD36) facilitates tissue FA uptake and is expressed in ECs and pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d218e705513d95a2667ae5e2ca9f1217
https://pubmed.ncbi.nlm.nih.gov/30047927