Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Steve Stirdivant"'
Publikováno v:
Particle and Fibre Toxicology, Vol 14, Iss 1, Pp 1-16 (2017)
Abstract Background To better assess potential hepatotoxicity of nanomaterials, human liver HepG2 cells were exposed for 3 days to five different CeO2 (either 30 or 100 μg/ml), 3 SiO2 based (30 μg/ml) or 1 CuO (3 μg/ml) nanomaterials with dry prim
Externí odkaz:
https://doaj.org/article/24c120aed77f4341870337242735d18e
Autor:
Jianing Xu, Ed Reznik, Ho-Joon Lee, Gunes Gundem, Philip Jonsson, Judy Sarungbam, Anna Bialik, Francisco Sanchez-Vega, Chad J Creighton, Jake Hoekstra, Li Zhang, Peter Sajjakulnukit, Daniel Kremer, Zachary Tolstyka, Jozefina Casuscelli, Steve Stirdivant, Jie Tang, Nikolaus Schultz, Paul Jeng, Yiyu Dong, Wenjing Su, Emily H Cheng, Paul Russo, Jonathan A Coleman, Elli Papaemmanuil, Ying-Bei Chen, Victor E Reuter, Chris Sander, Scott R Kennedy, James J Hsieh, Costas A Lyssiotis, Satish K Tickoo, A Ari Hakimi
Publikováno v:
eLife, Vol 8 (2019)
While genomic sequencing routinely identifies oncogenic alterations for the majority of cancers, many tumors harbor no discernable driver lesion. Here, we describe the exceptional molecular phenotype of a genomically quiet kidney tumor, clear cell pa
Externí odkaz:
https://doaj.org/article/6a397e8b7d454269bfb746b823085605
Autor:
Robert P. Mohney, Steve Stirdivant, Haiyan Fu, Douglas M. McCarty, Ricardo J. Pineda, Aaron S. Meadows
Publikováno v:
Metabolic Brain Disease. 32:1403-1415
The monogenic defects in specific lysosomal enzymes in mucopolysaccharidosis (MPS) III lead to lysosomal storage of glycosaminoglycans and complex CNS and somatic pathology, for which the detailed mechanisms remain unclear. In this study, serum sampl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484ae4bdb7b37960ebee8c5b7c554944
https://doi.org/10.1007/s11011-017-0009-1
https://doi.org/10.1007/s11011-017-0009-1
Autor:
Scott R. Kennedy, Wenjing Su, Anna Bialik, Yiyu Dong, Gunes Gundem, Paul S Jeng, Steve Stirdivant, Ying-Bei Chen, A. Ari Hakimi, Ed Reznik, James J. Hsieh, Zachary P. Tolstyka, Jonathan A. Coleman, Jake G. Hoekstra, Philip Jonsson, Jie Tang, Jianing Xu, Francisco Sanchez-Vega, Li Zhang, Satish K. Tickoo, Chad J. Creighton, Elli Papaemmanuil, Daniel M. Kremer, Ho-Joon Lee, Costas A. Lyssiotis, Chris Sander, Paul Russo, Jozefina Casuscelli, Victor E. Reuter, Peter Sajjakulnukit, Judy Sarungbam, Nikolaus Schultz, Emily H. Cheng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4c75b48f89c54963a98d4bf240269e1
https://doi.org/10.7554/elife.38986.025
https://doi.org/10.7554/elife.38986.025
Autor:
Yiyu Dong, Nikolaus Schultz, Ying-Bei Chen, Jonathan A. Coleman, Jianing Xu, Jake G. Hoekstra, Emily H. Cheng, Chris Sander, Li Zhang, Elli Papaemmanuil, James J. Hsieh, Jozefina Casuscelli, Daniel M. Kremer, Eduard Reznik, Ho-Joon Lee, Steve Stirdivant, Francisco Sanchez-Vega, Wenjing Su, Paul S Jeng, A. Ari Hakimi, Chad J. Creighton, Anna Bialik, Scott R. Kennedy, Victor E. Reuter, Judy Sarungbam, Peter Sajjakulnukit, Satish K. Tickoo, Philip Jonsson, Jie Tang, Costas A. Lyssiotis, Zachary P. Tolstyka, Paul Russo, Gunes Gundem
Publikováno v:
eLife, Vol 8 (2019)
While genomic sequencing routinely identifies oncogenic alterations for the majority of cancers, many tumors harbor no discernable driver lesion. Here, we describe the exceptional molecular phenotype of a genomically quiet kidney tumor, clear cell pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184aeab01060500759dca2ad8507f813
https://elifesciences.org/articles/38986
https://elifesciences.org/articles/38986
Autor:
Ed Reznik, Emily H. Cheng, A. Rose Brannon, Chad J. Creighton, Victor E. Reuter, B. Arman Aksoy, A. Ari Hakimi, Eric Minwei Liu, Steve Stirdivant, William Lee, Ronglai Shen, James J. Hsieh, Ying-Bei Chen, Chris Sander, Chung-Han Lee, Satish K. Tickoo, Augustin Luna, Paul Russo, Yang Chen
Publikováno v:
Cancer Cell. 29:104-116
Dysregulated metabolism is a hallmark of cancer, manifested through alterations in metabolites. We performed metabolomic profiling on 138 matched clear cell renal cell carcinoma (ccRCC)/normal tissue pairs and found that ccRCC is characterized by bro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74250f44eb28d999c7ca504856c2d659
https://doi.org/10.1016/j.ccell.2015.12.004
https://doi.org/10.1016/j.ccell.2015.12.004
Autor:
Marc Abrams, Laura Sepp-Lorenzino, Steve Stirdivant, Joan Zugay-Murphy, Keith W. Rickert, Xianzhi Mao, Stephen C. Beck, Mark E. Fraley, Robert M. Garbaccio, Rob Lobell, Youwei Yan, Bob Drakas, Paul Zuck, Sylvie Jezequel-Sur, Kelly Hamilton, Timothy J. Hartingh, Constantine Kreatsoulas, Edward S. Tasber, Sanjeev Munshi, Antonella Converso, Eileen S. Walsh, George D. Hartman, Carolyn A. Buser, Weikang Tao, V V Sardana
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1240-1244
A high throughput screening campaign was designed to identify allosteric inhibitors of Chk1 kinase by testing compounds at high concentration. Activity was then observed at K(m) for ATP and at near-physiological concentrations of ATP. This strategy l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a164d70b45a247a3957cdbd7608b23b
https://doi.org/10.1016/j.bmcl.2008.12.076
https://doi.org/10.1016/j.bmcl.2008.12.076
Autor:
James Hardwick, Xianzhi Mao, Constanine Kreatsoulas, Eileen S. Walsh, Sanjeev Munshi, Marc Abrams, George D. Hartman, Laura Sepp-Lorenzino, Mark E. Fraley, Rob Lobell, Kelly Hamilton, Lawrence Kuo, Carolyn A. Buser, Weikang Tao, Robert M. Garbaccio, Mari Ikuta, Keith W. Rickert, Edward S. Tasber, Bob Drakas, Steve Stirdivant, Stephen C. Beck, Shaei Huang, Youwei Yan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6280-6285
From HTS lead 1, a novel benzoisoquinolinone class of ATP-competitive Chk1 inhibitors was devised and synthesized via a photochemical route. Using X-ray crystallography as a guide, potency was rapidly enhanced through the installation of a tethered b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8392ef471e763e4ddf93eeb0d6112007
https://doi.org/10.1016/j.bmcl.2007.09.007
https://doi.org/10.1016/j.bmcl.2007.09.007
Autor:
Eileen S. Walsh, Steve Stirdivant, George D. Hartman, Kelly Hamilton, Marc Abrams, Robert M. Garbaccio, Laura Sepp-Lorenzino, Lawrence Kuo, Steve Beck, Joan Zugay Murphy, Constantine Kreatsoulas, Justin T. Steen, Sanjeev Munshi, Carolyn A. Buser, Weikang Tao, Shaei Huang, Youwei Yan, V V Sardana, Bob Drakas, Mari Ikuta, James Hardwick, Keith W. Rickert, Mark E. Fraley, Elizabeth Mahan, Xianzhi Mao, Rob Lobell, Michael Reilly
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5907-5912
Through a comparison of X-ray co-crystallographic data for 1 and 2 in the Chek1 active site, it was hypothesized that the affinity of the indolylquinolinone series (2) for Chek1 kinase would be improved via C6 substitution into the hydrophobic region
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9417e1526f4bd74048baad5244ad1fea
https://doi.org/10.1016/j.bmcl.2006.08.053
https://doi.org/10.1016/j.bmcl.2006.08.053
Publikováno v:
Cancer Research. 77:5255-5255
The MNU-induced model of ER+ mammary cancers in Sprague-Dawley rats has routinely been employed in screening for chemopreventive agents. We recently reported that metformin was ineffective in preventing mammary cancers in rats on a standard diet (Tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d5fdd390ae7cb8bc77b6258098d864b
https://doi.org/10.1158/1538-7445.am2017-5255
https://doi.org/10.1158/1538-7445.am2017-5255