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A Novel Rat Model of ADHD-like Hyperactivity/Impulsivity after Delayed Reward Has Selective Loss of Dopaminergic Neurons in the Right Ventral Tegmental Area

Autor: Oorschot, Sarah E. Kohe, Emma K. Gowing, Steve Seo, Dorothy E.

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 14; Pages: 11252

In attention deficit hyperactivity disorder (ADHD), hyperactivity and impulsivity occur in response to delayed reward. Herein we report a novel animal model in which male Sprague-Dawley rats exposed to repeated hypoxic brain injury during the equival

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::8b2e138588741560b414b26fd2b178b5

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A schizophrenia risk factor induces marked anatomical deficits at GABAergic ‐dopaminergic synapses in the rat ventral tegmental area: Essential evidence for new targeted therapies

Autor: David K. Bilkey, Stephanie M. Hughes, Rachel J. Sizemore, Roseanna A Smither, Hollie E Wicky, Steve Seo, Louise C. Parr-Brownlie, Dorothy E. Oorschot, Karen L Reader

Publikováno v: Journal of Comparative Neurology. 529:3946-3973

To develop new therapies for schizophrenia, evidence accumulated over decades highlights the essential need to investigate the GABAergic synapses that presynaptically influence midbrain dopaminergic neurons. Since current technology restricts these s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82fd4d3a9e20c0be1ba5f6f695ceba52
https://doi.org/10.1002/cne.25225

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Delayed Double Treatment with Adult-Sourced Adipose-Derived Mesenchymal Stem Cells Increases Striatal Medium-Spiny Neuronal Number, Decreases Striatal Microglial Number, and Has No Subventricular Proliferative Effect, after Acute Neonatal Hypoxia-Ischemia in Male Rats

Autor: Haylee K. Basham, Benjamin E. Aghoghovwia, Dorothy E. Oorschot, Panagiotis Papaioannou, Steve Seo

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 7862, p 7862 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 15

Perinatal hypoxia-ischemia (HI) is a major cause of striatal injury. Delayed post-treatment with adult-sourced bone marrow-derived mesenchymal stem cells (BMSCs) increased the absolute number of striatal medium-spiny neurons (MSNs) following perinata

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c400b7ea2dad1b4ff4189031d6cf1c
https://www.mdpi.com/1422-0067/22/15/7862

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Postnatal expression of thalamic GABAA receptor subunits in the stargazer mouse model of absence epilepsy

Autor: Beulah Leitch, Steve Seo

Publikováno v: NeuroReport. 28:1255-1260

Absence seizures are known to originate from disruptions within the corticothalamocortical network; however, the precise underlying cellular and molecular mechanisms that induce hypersynchronicity and hyperexcitability are debated and likely to be co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba47742b9451f65f59109b090f21780
https://doi.org/10.1097/wnr.0000000000000909

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Altered thalamic GABAA-receptor subunit expression in the stargazer mouse model of absence epilepsy

Autor: Beulah Leitch, Steve Seo

Publikováno v: Epilepsia. 55(2)

Summary Purpose Absence seizures, also known as petit mal seizures, arise from disruptions within the cortico-thalamocortical network. Interconnected circuits within the thalamus consisting of inhibitory neurons of the reticular thalamic nucleus (RTN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b040005ff0859405b2e4b6280e66cbc4
https://pubmed.ncbi.nlm.nih.gov/24417662

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