Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Steve Petrou"'
Autor:
Dmitry A. Ovchinnikov, Sharon Jong, Claire Cuddy, Kelly Dalby, Orrin Devinsky, Saul Mullen, Snezana Maljevic, Steve Petrou
Publikováno v:
Stem Cell Research, Vol 76, Iss , Pp 103367- (2024)
Many developmental and epileptic encephalopathies (DEEs) result from variants in cation channel genes. Using mRNA transfection, we generated and characterised an induced pluripotent stem cell (iPSC) line from the fibroblasts of a male late-onset DEE
Externí odkaz:
https://doaj.org/article/ae358e4384da49808c1b9d0ed4b4204c
Publikováno v:
Brain research. 1751
Dravet Syndrome (DS) is a genetic neurodevelopmental disease. Recurrent severe seizures begin in infancy and co-morbidities follow, including developmental delay, cognitive and behavioral dysfunction. A majority of DS patients have an SCN1A heterozyg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923a953d7e9d3e2cebafcfb4a7322214
https://pubmed.ncbi.nlm.nih.gov/33069731
https://pubmed.ncbi.nlm.nih.gov/33069731
Autor:
Linlin Ma, Yanni K.-Y. Chin, Glenn F. King, Chun Yuen Chow, Steve Petrou, Eivind A. B. Undheim
This thesis describes the functional and structural characterisation of several novel peptides that modulate the activity of voltage-gated sodium channel 1.1 (NaV1.1), a putative target for the development of therapeutics to treat Dravet syndrome (DS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed5dfb42b5aad844928bfcc6f7489c4d
https://doi.org/10.14264/uql.2019.883
https://doi.org/10.14264/uql.2019.883
Autor:
Steve Petrou, Kay L. Richards
Genetic Generalized Epilepsy (GGE) encompasses two well-studied syndrome specific epilepsies. Here we discuss recent advances in our understanding of mouse models of Generalized Epilepsy with Febrile Seizures plus (GEFS+) and Dravet syndrome. This di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a0f7912cae32bf47342dc638909d54d
https://doi.org/10.1016/b978-0-12-804066-9.00053-5
https://doi.org/10.1016/b978-0-12-804066-9.00053-5
Sez-6 Proteins Affect Dendritic Arborization Patterns and Excitability of Cortical Pyramidal Neurons
Autor:
Pankaj Sah, Mary H. Kim, E. S. Louise Faber, Vicki E. Hammond, Jenny M. Gunnersen, Philip J. Davies, Steve Petrou, Melanie de Silva, Seong-Seng Tan, Joanne M. Britto, Stephanie J. Fuller
Publikováno v:
Neuron. 56:621-639
SummaryDevelopment of appropriate dendritic arbors is crucial for neuronal information transfer. We show, using seizure-related gene 6 (sez-6) null mutant mice, that Sez-6 is required for normal dendritic arborization of cortical neurons. Deep-layer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b0331c0fcdc1e16ed92ca76fd1b9c3
https://doi.org/10.1016/j.neuron.2007.09.018
https://doi.org/10.1016/j.neuron.2007.09.018
Autor:
Marian Todaro, John D. Wark, Terence J. O'Brien, Steve Petrou, Carol J. Milligan, Eleanor J. Mackie, Sandra J. Petty
Publikováno v:
Journal of Clinical Neuroscience. 21:2039-2040
An increase in fracture risk is well established in patients with epilepsy. However, the mechanism for this association is less well defined. Our aim was to isolate sodium channel currents in mouse primary calvarial osteoblasts using whole-cell patch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b61e6c5d471e4a7ee094eee43c8acdb0
https://doi.org/10.1016/j.jocn.2014.06.035
https://doi.org/10.1016/j.jocn.2014.06.035
Autor:
Alison L. Clarke, Michaella C. Richards, Samuel F. Berkovic, Leanne M. Dibbens, Bree L. Hodgson, Steve Petrou, Louise A. Harkin, Ingrid E. Scheffer, John C. Mulley
Rare GABAA receptor γ2 and α1 subunit mutations of pathogenic effect have been described segregating in families with “monogenic” epilepsies. We now report globally on the genetic variation contained within all 16 neuronal GABAA receptor subuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e088b83813e607c38785560a0843702e
https://hdl.handle.net/1959.8/136021
https://hdl.handle.net/1959.8/136021